Elevated salivary uric acid levels among adolescents with eating disorders

Giesser, Ruth; Goltser-Dubner, Tanya; Pevzner, Dalya; Shalev, Amit; Masarwa, Ranin; Canetti, Laura; Meltzer, A; Qutna, Nidal; Ratson, Roi; Kianski, Ela; Keller, Shikma; Galili-Weisstub, Esti; Segman, Ronen

doi:10.1007/s40519-019-00799-1

Cited by 3 publications

(1 citation statement)

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“…Gupta et al found that 9% of patients presenting with a consecutive eating disorder had raised levels of uric acid upon initial presentation, which might be explained by an increase in the degeneration of ATP as a result of increased physical exertion or a decrease in uric acid clearance by the renal system due to starvation [ 11 ]. A study conducted by Giesser et al that included the adolescent population showed that salivary uric acid levels were raised significantly in patients with eating disorders when compared with control [ 12 ]. During the reproductive years, women usually have reduced levels of uric acid when compared with men, which are in part a result of the uricosuric effect exerted by estrogen and progesterone on the uric acid clearance by the renal system.…”

Section: Reviewmentioning

confidence: 99%

Salivary Uric Acid: A Noninvasive Wonder for Clinicians?

Jaiswal¹,

Madaan²,

Acharya³

et al. 2021

Cureus

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This review is a summary of the modern-day approach and recent trend in the determination of uric acid in the saliva of humans and its use in diagnosis by clinicians. Uric acid, which is the end product obtained from the breakdown of purine nucleotides, is an important biomarker associated with various conditions. Uric acid is found in various body fluids, such as serum, plasma, and urine. It can be used as an important tool for various diseases, such as gout and hyperuricemia, or conditions that are associated with increased oxidative stress. Recently, there has been an emergence of studies that have utilized uric acid concentrations measured in the saliva and studied its association with various diseases. Salivary uric acid can prove to be a noninvasive method to provide a diagnosis of serious illness. A raised uric acid level in the saliva can be associated with cancer, human immunodeficiency virus (HIV) infection, gout, and hypertension. A reduced level of salivary uric acid on the other hand can be a marker for Alzheimer’s disease, progression of multiple sclerosis, and impairment of cognition. Online search databases, including Google Scholar, Scopus, PubMed, and Web of Science, were searched, and articles that were published before September 2021 based on salivary uric acid analysis were analyzed for this review. Uric acid is an essential biomarker that has antioxidant properties. Assessment of salivary uric acid levels was found to be essential in conditions such as cancer, metabolic syndrome, neurological conditions, psychiatric conditions, human immunodeficiency virus, and gout and in monitoring treatment of hyperuricemia. Although having importance in diagnosis and therapeutic monitoring, salivary uric acid analysis has not gained enough popularity due to limitations such as saliva collection and sample processing issues. With proper education and standardization, salivary uric acid analysis can be used as a cost-effective and noninvasive tool for getting a clue about antioxidant biomarker concentration in saliva and hence various diseases associated with oxidative stress.

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Section: Reviewmentioning

confidence: 99%