2023
DOI: 10.1002/dvdy.676
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Elevated Id2 expression causes defective meiosis and spermatogenesis in mice

Zhen He,
Rong‐Ge Yan,
Qin‐Bang Shang
et al.

Abstract: BackgroundInhibitors of DNA binding (ID) proteins mainly inhibit gene expression and regulate cell fate decisions by interacting with E‐proteins. All four ID proteins (ID1–4) are present in the testis, and ID4 has a particularly important role in spermatogonial stem cell fate determination. Several lines of evidence indicate that ID proteins are involved in meiosis; however, functional experiments have not been conducted to validate this observation.ResultsIn this study, we report that ID2 is enriched in sperm… Show more

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