Elevated second trimester human chorionic gonadotropin level associated withadverse pregnancy outcome

Önderoǧlu, L.; Kabukçu, Aysel

doi:10.1016/s0020-7292(96)02830-5

Cited by 50 publications

(36 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results are consistent with that of Vidyabati et al and Gonen et al who conducted a prospective cohort study on pregnant patients and found that women with elevated levels of beta HCG had a significantly higher risk of hypertension. 4,15 Observations made in present study were also consistent with those of Sorensen et al, Wenstrom et al, Benn et al, Yang et al and Onderoglu et al 5,6,[16][17][18] The above association could be explained by the early placental vascular damage in preeclamptic women leading to decreased oxygen supply, which might result in increased HCG production by the hyperplastic syncytotrophoblastic cells.…”

Section: Discussionsupporting

confidence: 91%

Serum β HCG and lipid profile in early second trimester as predictors of hypertensive disorders of pregnancy

Arora¹,

Sharma²,

Gupta³

2017

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

INTRODUCTIONHypertensive disorders complicating pregnancy are common (5-10%) and form one member of the deadly triad, along with haemorrhage and infection that contribute greatly to maternal morbidity and mortality rates.1 Among the hypertensive disorders complicating pregnancy, preeclampsia is the most common. Incidence of preeclampsia in US ranges from 2-6% in healthy nulliparous women and in the developing world, it is 4-18%.2 Worldwide, preeclampsia and eclampsia are responsible for approximately 14% of maternal deaths per year (50,000-75,000). 2How pregnancy incites or aggravates hypertension remains unsolved despite decades of intensive research. At present, there are different hypotheses which are the subject of extensive investigations like placental ischemia ABSTRACT Background: Hypertensive disorders complicating pregnancy are common (5-10%) and form one member of the deadly triad, along with haemorrhage and infection that contribute greatly to maternal morbidity and mortality rates. Although overt illness rarely appears until third trimester, there are multiple indications that the disease process begin early in the pregnancy. Since years there has been a search for an early predictor of PIH so that special antenatal care can be given to these patients. This prospective study was one of the efforts to predict preeclampsia by measuring serum beta HCG levels and lipid profile in 2nd trimester of pregnancy. Methods: This was a prospective study carried out on 200 pregnant women attending the outpatient antenatal clinic and estimating serum beta HCG and lipid profile in early second trimester. Results: Most of the women who entered the study were in the age group of 21-30 years. Out of 200 patients, 164 remained normotensive and 36 turned out to be hypertensive. 50% of patients in the normotensive group and 75% in the hypertensive group were primigravidas indicating that primigravidas have a higher risk of developing PIH compared to multiparas. No correlation was found between the residence and occurrence of hypertension. Among 45 patients with beta HCG >40,000mIU/mL, 30 developed hypertensions, whereas, among 155 patients who had levels <40,000 mIU/mL, only 6 developed hypertension (p<0.0001). Maximum number of cases among the hypertensive group (83.33%) had serum TG levels >200 mg/dl. Among the hypertensive group, 83.4% cases had levels >250 mg/dl. A significantly higher number of hypertensive cases i.e.75% had serum VLDL >40 mg/dl. 83.4% of hypertensive patients had serum LDL >140 mg/dl. In our study, 5.5% of the cases among normotensive group had serum HDL <40 mg/dl whereas, 16.6% of cases among the hypertensive group had serum HDL <40 mg/dl. Conclusions: Women with raised serum beta HCG and/or dyslipidemia should be carefully followed up to achieve a more favourable outcome for both mother and the fetus.

show abstract

Section: Discussionsupporting

confidence: 91%

Serum β HCG and lipid profile in early second trimester as predictors of hypertensive disorders of pregnancy

Arora¹,

Sharma²,

Gupta³

2017

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

show abstract

“…An association has been reported between preeclampsia and elevated third trimester hCG levels 2 . Considerable evidence suggests an association between serum hCG levels and preclampsia [7][8][9][10][11][12] . Physiological concentrations of hCG is significantly increased in vitro capillary formation and migration of endothelial cells in a dosedependant manner and has a novel function in ueterine adaptation to early pregnancy 13 .…”

Section: Introductionmentioning

confidence: 99%

The association between serum betahuman Chorionic gonadotropin and Preeclampsia

Begum

Ara

Tanira³

et al. 2015

J Dhaka Med Coll

View full text Add to dashboard Cite

show abstract

“…This observation takes on an added significance because of reports that certain pregnancy disorders (e.g. Down syndrome, pre-eclampsia, early pregnancy loss) are characterized by abnormal hCG levels (Bogart et al 1987, Heinonen et al 1996, Hurley et al 1996, O'Leary et al 1996, Onderoglu & Kabukcu 1997, Haddow et al 1998. We have evidence that pregnancies which will not carry to term have an easily recognized difference in production of hCG isoforms (O'Connor et al 1998).…”

Section: Introductionmentioning

confidence: 87%

Early pregnancy human chorionic gonadotropin (hCG) isoforms measured by an immunometric assay for choriocarcinoma-like hCG

Kovalevskaya¹,

Birken²,

Kakuma³

et al. 1999

Journal of Endocrinology

View full text Add to dashboard Cite

Human chorionic gonadotropin (hCG) exhibits molecular heterogeneity in both its protein and carbohydrate moieties. This communication describes changes in hCG isoforms detected directly in clinical samples. These isoforms, quantified in blood or urine specimens, show a progression of change throughout normal pregnancy. Early pregnancy produces a type of hCG that resembles, in terms of immunoreactivity, a major form of hCG excreted in choriocarcinoma. The isoforms predominate for the first 5-6 weeks of gestation and then diminish, being replaced with the hCG isoforms which predominate throughout the remainder of pregnancy. The alteration in hCG isoform content occurs in both blood and urine. The progression of isoforms is best delineated by calculating the change in the ratio of the two forms, as many hCG assays either do not detect or fail to discriminate among these isoforms. An analogous pattern of hCG isoforms was observed in patients with in vitro fertilization pregnancies. hCG isolated from the pituitary displayed binding characteristics similar to those of the hCG derived from normal pregnancy urine. The early pregnancy hCG isoforms appear to have a differential expression in normal pregnancy as opposed to pregnancies which will not carry to term, suggesting that a determination of the relative balance of hCG isoforms may have diagnostic application in predicting pregnancy outcome.

show abstract

Elevated second trimester human chorionic gonadotropin level associated withadverse pregnancy outcome

Abstract: Unexplained elevation of human chorionic gonadotropin in the second trimester appears to be associated with adverse pregnancy outcome.

Cited by 50 publications

References 18 publications

Serum β HCG and lipid profile in early second trimester as predictors of hypertensive disorders of pregnancy

Serum β HCG and lipid profile in early second trimester as predictors of hypertensive disorders of pregnancy

The association between serum betahuman Chorionic gonadotropin and Preeclampsia

Early pregnancy human chorionic gonadotropin (hCG) isoforms measured by an immunometric assay for choriocarcinoma-like hCG

Contact Info

Product

Resources

About