Elevated serum alpha-fetoprotein in Wilms tumor may follow the same pattern of other fetal neoplasms after treatment: evidence from three cases

Crocoli, Alessandro; Madafferi, Silvia; Jenkner, Alessandro; Zaccara, Antonio; Inserra, Alessandro

doi:10.1007/s00383-007-2067-7

Cited by 14 publications

(10 citation statements)

References 12 publications

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“…In our case, the tumor showed dimensional regression after preoperative chemotherapy and the elevation of AFP middle responded to chemotherapy and returned to normal after nephrectomy. AFP levels have been reported to be higher in patients with metastatic disease, than in one case with thrombosis in inferior vena cava [1,12]. This case also had an associated testicular swelling, which in fact was the reason for investigating the AFP levels.…”

Section: Afp Levelsmentioning

confidence: 79%

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Classic Wilms tumor with raised alpha-fetoprotein levels: A case report and literature review

Shah¹,

Tiwari²,

Bothra³

2017

PUCR

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A B S T R A C TTumor markers have become important in the armamentarium of diagnostic and prognostic tools in the field of oncology. With advances in the scientific research they have created a place in the management protocols of various tumors. Alpha-fetoprotein (AFP) is one such tumor marker which is known to be elevated in liver tumors and germ cell tumors, especially those with the yolk sac elements. However, there are only a few reports describing elevated AFP levels in Wilms' tumor, the second most common primary intra-abdominal malignant tumor in children. We present a case of classic Wilms' tumor with raised AFP levels which followed the trend of treatment.

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Section: Afp Levelsmentioning

confidence: 79%

“…There are only few reports describing raised AFP in classic Wilms' tumor [1,8,9,11,12] [1,8,9,11,12]. Kısmet et al [8] suggested that persistence of high AFP level during preoperative chemotherapy period could reflect a poor response to chemotherapy.…”

Section: Afp Levelsmentioning

confidence: 99%

Classic Wilms tumor with raised alpha-fetoprotein levels: A case report and literature review

Shah¹,

Tiwari²,

Bothra³

2017

PUCR

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“…For example, Roth and colleagues first described WT presenting with elevated serum AFP [38]. Since this initial description, only four other WT cases have been documented with histologically classic type WT and elevated AFP [39][40][41]. More notably, elevated AFP is seen in the teratoid WT, in which more than 50% of the tumor is composed of teratoid elements [42].…”

Section: Afp and Associated Rare Pediatric Solid Cancersmentioning

confidence: 99%

Alpha-Fetoprotein in Malignant Pediatric Conditions

Houwelingen¹,

Sandoval²

2016

Proof and Concepts in Rapid Diagnostic Tests and Technologies

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Abnormal serum α-fetoprotein (AFP) levels are frequently observed in common disorders such as spina bifida or Down's syndrome in the fetus and cancer in children and adults. The focus of this chapter summarizes on the role of serum α-fetoprotein (AFP) as a useful biomarker in malignant pediatric tumors. The fetal yolk sac and liver generate high levels of AFP during gestation and decline over the next 12 months of infancy, and only trace amounts are detected in childhood. As a result, persistent elevation of AFP correlates with a number of select pediatric malignant conditions. Serum AFP is overexpressed in a considerable fraction of germ cell tumors (GCTs), hepatoblastoma (HB), and hepatocellular carcinoma (HCC). We provide the reader with a review of AFP as a useful specific marker for the diagnosis, management, and followup in select pediatric cancers.

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“…Alpha-fetoprotein (AFP) is an oncodevelopmental antigen that is commonly elevated in patients with hepatoblastoma and yolk salk tumor. High serum AFP levels are rarely found in patients with WT and few cases were reported [8][9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

Familial synchronous bilateral teratoid Wilms tumor with elevated alpha-fetoprotein level

Okur

Pınarlı

Karadeniz

et al. 2012

Tumori

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Familial Wilms tumor is a rare entity that accounts for only 1–2% of all Wilms tumor cases, with an earlier age of onset and an increased frequency of bilateral tumors. Teratoid Wilms tumor is a variant of nephroblastoma with a predominance of heterologous tissues comprising more than 50% of the tumor volume. Wilms tumor does not usually secrete any specific tumor marker and all teratoid Wilms tumor cases previously reported were sporadic non-secreting neoplasms. Here we describe an infant with familial synchronous bilateral teratoid Wilms tumor whose serum alpha-fetoprotein level was elevated. To our knowledge, this extremely rare type of case is reported for the first time in the literature.

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Elevated serum alpha-fetoprotein in Wilms tumor may follow the same pattern of other fetal neoplasms after treatment: evidence from three cases

Cited by 14 publications

References 12 publications

Classic Wilms tumor with raised alpha-fetoprotein levels: A case report and literature review

Classic Wilms tumor with raised alpha-fetoprotein levels: A case report and literature review

Alpha-Fetoprotein in Malignant Pediatric Conditions

Familial synchronous bilateral teratoid Wilms tumor with elevated alpha-fetoprotein level

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