Elevated serum and tissue VEGF associated with poor outcome in breast cancer patients

Study of expression and correlation of vascular endothelial growth factor with grading and staging of breast carcinoma

“…In our study we demonstrated, VEGF tissue expression was significantly associated with large tumor size (p-0.027). Similar results were observed in other previous studies (4,14,15,16) , Thus, confirming the dependence of tumor expansion on angiogenesis (14) . In contrast, no significant correlation was found in previous studies (8,10,11) .…”

Association of −2549 Insertion/Deletion Polymorphism of Vascular Endothelial Growth Factor with Breast Cancer in North Indian Patients

“…A significant association of sVEGF-C levels with the clinical stage has also been observed ( p = 0.002). Several studies have reported higher sVEGF levels in patients with breast cancer and many other types of cancer, with higher levels in metastatic disease than in localized disease or in progressive disease during treatment (Yamamoto et al, 1996;Salven et al, 1997Salven et al, , 1999Kraft et al, 1999;Adams et al, 2000;Heer et al, 2001;Ali et al, 2011). In a previous study from India, significantly higher sVEGF levels have been reported in breast cancer patients as compared to controls (Pande et al, 2011).…”

Oligoclonal selection of nanobodies targeting vascular endothelial growth factor

“…Among all molecules involved in angiogenesis, VEGF and its receptors seem to have important roles in the progression of the process (Ferrara et al 2003). This is reflected in the fact that increased levels of serum VEGF have been noted in breast, Data calculated using HEX V 8.0. prostate, and colorectal cancer patients (Duque et al 1999;George et al 2000;Ali et al 2011). For many years, there have been three primary methods to treat cancer, i.e., surgery followed by radiation therapy and/or chemotherapy.…”