Elevated serum angiotensin converting enzyme levels in metastatic ovarian dysgerminoma

Cotter, T. P.; Kealy, N.P.; Duggan, P F; Curtain, Andrew; Bredin, C. P.

doi:10.1016/s0954-6111(97)90045-7

Cited by 10 publications

(6 citation statements)

References 5 publications

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“…In this study by Erman et al [18], it was speculated that the cause of the increased ovarian ACE activity was not clear, but may be related to the aging process. Cotter et al [19] reported a patient with elevated serum ACE levels in metastatic ovarian carcinoma and suggested that serum ACE may be a marker for disseminated germinoma tumors and may be useful for monitoring treatment. In conjunction with this suggestion, we think that based on our results ACE might be a useful marker also in epithelial OC patients.…”

Section: Discussionmentioning

confidence: 99%

Assessment of serum angiotensin-converting enzyme in patients with epithelial ovarian cancer

Beyazıt

Ayhan

Çelik

et al. 2015

Arch Gynecol Obstet

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Section: Discussionmentioning

confidence: 99%

Assessment of serum angiotensin-converting enzyme in patients with epithelial ovarian cancer

Beyazıt

Ayhan

Çelik

et al. 2015

Arch Gynecol Obstet

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“…As for epithelial OC patients, serum ACE levels do not vary according to patient stage and pathological subtype. This situation suggests that serum angiotensin I converting enzyme may be a marker of disseminated germinoma (85).…”

Section: Ovarian Cancermentioning

confidence: 97%

Physiological and pathological roles of Ang II and Ang- (1-7) in the female reproductive system

et al. 2022

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The local Renin-Angiotensin System (RAS) has been demonstrated to exist in a wide range of tissues and organs, In the female reproductive system, it is mainly found in the ovary, uterus and placenta. The RAS system is made up of a series of active substances and enzymes, in addition to the circulating endocrine renin-angiotensin system. The active peptides Angiotensin II (Ang II) and Angiotensin (1-7) (Ang-(1-7)), in particular, appear to have distinct activities in the local RAS system, which also controls blood pressure and electrolytes. Therefore, in addition to these features, angiotensin and its receptors in the reproductive system seemingly get involved in reproductive processes, such as follicle growth and development, as well as physiological functions of the placenta and uterus. In addition, changes in local RAS components may induce reproductive diseases as well as pathological states such as cancer. In most tissues, Ang II and Ang- (1-7) seem to maintain antagonistic effects, but this conclusion is not always true in the reproductive system, where they play similar functions in some physiological and pathological roles. This review investigated how Ang II, Ang- (1-7) and their receptors were expressed, localized, and active in the female reproductive system. This review also summarized their effects on follicle development, uterine and placental physiological functions. The changes of local RAS components in a series of reproductive system diseases including infertility related diseases and cancer and their influence on the occurrence and development of diseases were elucidated. This article reviews the physiological and pathological roles of Ang II and Ang- (1-7) in female reproductive system,a very intricate system of tissue factors that operate as agonists and antagonists was found. Besides, the development of novel therapeutic strategies targeting components of this system may be a research direction in future.

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“…No differences were observed between the stage of the tumor (FIGO I–II vs. FIGO III–IV) as well as between serous and non-serous OC patients [ 94 ]. Cotter et al [ 95 ] suggested on the basis of case report patients with metastatic ovarian carcinoma that serum ACE1 level may be a marker for ovarian germ cell tumors (dysgerminoma) and may be useful for monitoring treatment [ 95 ]. On the other hand, Correa-Noronha et al [ 96 ] did not observe an association between the insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene and epithelial OC [ 96 ].…”

Section: Ovarian Diseases Related To the Ace2/ang-(1-7)/mas1 Axismentioning

confidence: 99%

Involvement of ACE2/Ang-(1-7)/MAS1 Axis in the Regulation of Ovarian Function in Mammals

Domińska

2020

IJMS

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In addition to the classic, endocrine renin-angiotensin system, local renin-angiotensin system (RAS) has been documented in many tissues and organs, including the ovaries. The localization and functional activity of the two opposing axes of the system, viz. ACE1/Ang II/AT1 and ACE2/Ang-(1-7)/MAS1, differs between animal species and varied according to the stage of follicle development. It appears that the angiotensin peptides and their receptors participate in reproductive processes such as folliculogenesis, steroidogenesis, oocyte maturation, and ovulation. In addition, changes in the constituent compounds of local RAS may contribute to pathological conditions, such as polycystic ovary syndrome, ovarian hyperstimulation syndrome, and ovarian cancer. This review article examines the expression, localization, metabolism, and activity of individual elements of the ACE2/Ang-(1-7)/MAS1 axis in the ovaries of various animal species. The manuscript also presents the relationship between the secretion of gonadotropins and sex hormones and expression of Ang-(1-7) and MAS1 receptors. It also summarizes current knowledge regarding the positive and negative impact of ACE2/Ang-(1-7)/MAS1 axis on ovarian function.

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Elevated serum angiotensin converting enzyme levels in metastatic ovarian dysgerminoma

Cited by 10 publications

References 5 publications

Assessment of serum angiotensin-converting enzyme in patients with epithelial ovarian cancer

Assessment of serum angiotensin-converting enzyme in patients with epithelial ovarian cancer

Physiological and pathological roles of Ang II and Ang- (1-7) in the female reproductive system

Involvement of ACE2/Ang-(1-7)/MAS1 Axis in the Regulation of Ovarian Function in Mammals

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