Elevated Serum anti-Helicobacter pylori IgG Levels is a Predictor of Successful Eradication Therapy

Abstract

habits, prior PPI intake, kind of PPI, serum IgG value and degree of atrophy. Univariate analysis showed that high serum IgG significantly predicts successful eradication (odds ratio (OR) 2.583, 95% confidence interval (CI) 1. 285-5.191, p=0.008). The eradication rate was 77% (43/56) in the ≥45 U/mL group and 56% (73/130) in the <45 U/ mL group, and significance was confirmed by multivariate analysis (OR 2.626, 95% CI 1. 269-5.436, p=0.009). Multivariate analysis showed a trend that advanced age (≥70 year-old) increased the rate of successful eradication (OR 1.669, p=0.132 INTRODUCTIONHelicobacter pylori (H. pylori) eradication is the standard treatment for preventing gastric ulcers and cancer throughout the world. In Japan, H. pylori eradication therapy for H. pylori gastritis has been approved by the National Health Insurance system since February 2013. For primary eradication therapy, triple drug therapy including a proton pump inhibitor (PPI), clarithromycin and amoxicillin for one week is the approved regimen. Despite more patients undergoing this eradication regimen in Japan, the success rate of primary H. pylori eradication has been decreasing over the last decade because of emerging antibiotic resistance [1] . To identify a predictor of successful primary Helicobacter pylori (H. pylori) eradication assessed in routine clinical practice. METHODS: From February 2013 to January 2015, 186 patients underwent primary eradication therapy. We retrospectively reviewed the medical records. All patients underwent EGD before eradication therapy and H. pylori infection was diagnosed by ≥10 U/mL serum anti-H. pylori IgG. We used standard triple therapy including a proton pump inhibitor (PPI) (rabeprazole 10 mg or lansoprazole 30 mg), clarithromycin 200 mg and amoxicillin 750 mg twice daily for seven days. To determine if eradication succeeded, a 13 C-urea breath test was performed on all patients more than eight weeks after primary eradication. RESULTS: The overall success rate of H. pylori eradication therapy was 62% (116/186). We assessed potential predictors of successful primary H. pylori eradication therapy including gender, age, smoking

Factors Affecting the Intraluminal Therapy for Helicobacter pylori Infection

“…Shinozaki et al reported that "high serum anti-HPIgG levels significantly predicts successful eradication of oral antibiotic therapy (OR: 2.583; 95% CI: 1.285-5.191; p = 0.008) due to the co-operative effect of antibiotic susceptibility and high humoral immunity" [33]. Our study showed that the eradication rate of ILTHPI was not influenced by serum anti-HPIgG.…”