Elevated Serum Anti-Saccharomyces cerevisiae, Anti-I2 and Anti-OmpW Antibody Levels in Patients with Suspicion of Celiac Disease

Ashorn, Sara; Raukola, Hanna; Välineva, Tuuli; Ashorn, Merja; Wei, Bo; Braun, Jonathan; Rantala, Immo; Kaukinen, Katri; Luukkaala, Tiina; Collin, Pekka; Mäki, Markku; Iltanen, Sari

doi:10.1007/s10875-008-9200-9

Cited by 33 publications

(34 citation statements)

References 53 publications

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“…The presence of anti-I2 serum antibodies in Crohn's disease patients was subsequently shown to be positively associated with the prognosis (19). Anti-I2 antibodies have also been associated with the diagnosis of celiac disease, including a decrease in titer after a gluten-free diet is initiated (204,205), of ankylosing spondylitis (206), and of chronic granulomatous disease (207). Whether P. fluorescens directly contributes to these chronic inflammatory conditions or whether anti-I2 antibodies are only indirect biomarkers of disease is undetermined.…”

Section: P Fluorescens and Inflammatory Bowel Diseasementioning

confidence: 99%

Microbiology, Genomics, and Clinical Significance of the Pseudomonas fluorescens Species Complex, an Unappreciated Colonizer of Humans

et al. 2014

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SUMMARY Pseudomonas fluorescens is not generally considered a bacterial pathogen in humans; however, multiple culture-based and culture-independent studies have identified it at low levels in the indigenous microbiota of various body sites. With recent advances in comparative genomics, many isolates originally identified as the “species” P. fluorescens are now being reclassified as novel Pseudomonas species within the P. fluorescens “species complex.” Although most widely studied for its role in the soil and the rhizosphere, P. fluorescens possesses a number of functional traits that provide it with the capability to grow and thrive in mammalian hosts. While significantly less virulent than P. aeruginosa , P. fluorescens can cause bacteremia in humans, with most reported cases being attributable either to transfusion of contaminated blood products or to use of contaminated equipment associated with intravenous infusions. Although not suspected of being an etiologic agent of pulmonary disease, there are a number of reports identifying it in respiratory samples. There is also an intriguing association between P. fluorescens and human disease, in that approximately 50% of Crohn's disease patients develop serum antibodies to P. fluorescens . Altogether, these reports are beginning to highlight a far more common, intriguing, and potentially complex association between humans and P. fluorescens during health and disease.

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Section: P Fluorescens and Inflammatory Bowel Diseasementioning

confidence: 99%

Microbiology, Genomics, and Clinical Significance of the Pseudomonas fluorescens Species Complex, an Unappreciated Colonizer of Humans

et al. 2014

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“…Like OmpA, OmpW is immunogenic in Salmonella induced reactive arthritis; all fractions producing immunoproliferative responses contained OmpA and OmpW [46]. Sixty percent of Celiac disease patients were seropositive for Bacterioides OmpW antibodies [67], and serum levels decreased significantly when patents were on a gluten free diet [68]. It was suggested that OmpW may contribute to the pathogenicity of inflammation in celiac disease [67].…”

Section: Ompw Familymentioning

confidence: 99%

Eight Stranded β -Barrel and Related Outer Membrane Proteins: Role in Bacterial Pathogenesis

McClean¹

2012

PPL

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Gram negative bacteria have evolved many mechanisms of attaching to and invading host epithelial and immune cells. In particular, many outer membrane proteins (OMPs) are involved in this initial interaction between the pathogen and their host. This review focuses on a number of small pore-forming OMPs that are all composed of eightstranded β- barrel proteins and include members of the OmpA, OmpW and OmpX families of proteins. These proteins, together with the related OmpA-like peptidoglycan associated lipoproteins, are involved in interactions with host cells and are mediators of virulence. In many cases, these proteins interact with host immune cells and can be considered as pathogen associated molecular patterns (PAMPS) due to their ability to signal via Toll like receptor molecules and other pattern recognition receptors. The role of these proteins in pathogenesis is discussed here, together with the potential for these proteins to be used as immunoprophylactic agents to protect against infection.

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“…Anti-microbial antibody formation has also been reported in CD. ASCAs remain the most widely investigated antibodies [22][23][24][25][26] in this patient group but increasing experimental data are available on newly discovered antibodies such as anti-I2 or anti-OmpW (Bacteroides caccae TonBlinked outer membrane protein) [27,28] . The frequency of ASCA varied from 27% to 59% in various studies, owing to the differences in the number and the age of the patients as well as the commercial assays used for antibody detection.…”

Section: Introductionmentioning

confidence: 99%

Anti-microbial antibodies in celiac disease: Trick or treat?

Papp¹,

Földi²,

Altorjay³

et al. 2009

WJG

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AIM:To determine the prevalence of a new set of anti-glycan and anti-outer membrane protein (anti-OMP) antibodies in a Hungarian cohort of adult Celiac disease (CD) patients. METHODS:190 consecutive CD patients [M/F: 71/119, age:39.9 (SD:14.1) years], 100 healthy, and 48 gastrointestinal controls were tested for glycan antiSaccharomyces cerevisiae (gASCA), anti-laminaribioside (ALCA), anti-chitobioside, anti-mannobioside, anti-OMP antibodies and major NOD2/CARD15 mutations. Thirty out of 82 CD patients enrolled at the time of diagnosis were re-evaluated for the same antibodies after longstanding gluten-free diet (GFD). RESULTS:65.9% of the CD patients were positive for at least one of the tested antibodies at the time of the diagnosis. Except anti-OMP and ALCA, antimicrobial antibodies were exclusively seen in untreated CD; however, the overall sensitivity was low. Any glycan positivity (LR+: 3.13; 95% CI: 2.08-4.73) was associated with an increased likelihood ratio for diagnosing CD. Significant correlation was found between the levels of anti-glycan and anti-endomysial or anti-transglutaminase antibodies. Anti-glycan positivity was lost after longstanding GFD. Anti-glycan antibody titers were associated with symptoms at presentation, but not the presence of NOD2/CARD15 mutations. Patients with severe malabsorption more frequently had multiple antibodies at diagnosis (P = 0.019). CONCLUSION:The presence of anti-glycan antibodies in CD seems to be secondary to the impaired small bowel mucosa which can lead to increased antigen presentation. Furthermore, anti-glycan positivity may be considered an additional marker of CD and dietary adherence.

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Elevated Serum Anti-Saccharomyces cerevisiae, Anti-I2 and Anti-OmpW Antibody Levels in Patients with Suspicion of Celiac Disease

Cited by 33 publications

References 53 publications

Microbiology, Genomics, and Clinical Significance of the Pseudomonas fluorescens Species Complex, an Unappreciated Colonizer of Humans

Microbiology, Genomics, and Clinical Significance of the Pseudomonas fluorescens Species Complex, an Unappreciated Colonizer of Humans

Eight Stranded β -Barrel and Related Outer Membrane Proteins: Role in Bacterial Pathogenesis

Anti-microbial antibodies in celiac disease: Trick or treat?

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Elevated Serum Anti-Saccharomyces cerevisiae, Anti-I2 and Anti-OmpW Antibody Levels in Patients with Suspicion of Celiac Disease

Cited by 33 publications

References 53 publications

Microbiology, Genomics, and Clinical Significance of the Pseudomonas fluorescens Species Complex, an Unappreciated Colonizer of Humans

Microbiology, Genomics, and Clinical Significance of the Pseudomonas fluorescens Species Complex, an Unappreciated Colonizer of Humans

Eight Stranded &beta; -Barrel and Related Outer Membrane Proteins: Role in Bacterial Pathogenesis

Anti-microbial antibodies in celiac disease: Trick or treat?

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Eight Stranded β -Barrel and Related Outer Membrane Proteins: Role in Bacterial Pathogenesis