Elevated serum BAFF levels in patients with autoimmune hepatitis

Migita, Kiyoshi; Abiru, Seigo; Maeda, Yümi; Nakamura, Minoru; Komori, Atsumasa; Ito, Masahiro; Fujiwara, Shinsuke; Yano, Koji; Yatsuhashi, Hiroshi; Eguchi, Katsumi; Ishibashi, Hiromi

doi:10.1016/j.humimm.2007.03.010

Cited by 62 publications

(52 citation statements)

References 25 publications

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“…Elevated serum sCD30 or sCD30L is observed for viral infections and autoimmune diseases, and has been proposed as a marker for a T helper type (Th) 2 immune response. Increased circulating sCD30 is also present among CD30 + lymphoid malignancies such as Hodgkin lymphoma and nonHodgkin lymphoma [17][18][19].…”

Section: Discussionmentioning

confidence: 99%

Imbalance in serum soluble CD30/CD30L and CD40/CD40L systems are associated with ovarian tumors

et al. 2013

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Section: Discussionmentioning

confidence: 99%

Imbalance in serum soluble CD30/CD30L and CD40/CD40L systems are associated with ovarian tumors

et al. 2013

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“…TNF-α has been reported to activate cytotoxic T lymphocytes and/ or macrophages, and their cellular autoimmunity results in hepatocellular injury (6,7,9,10). These activated cells were also reported to produce B-cell activating factor belonging to the tumor necrosis factor family (BAFF), which stimulates B-cell inducing humoral autoimmunity (19). In theory, therefore, TNF inhibitor may be effective in the treatment of AIH; however, no reports have been published to date showing TNF inhibitor to be clinically useful as a treatment for AIH.…”

Section: Discussionmentioning

confidence: 99%

Improvement of Rheumatoid Arthritis and Autoimmune Hepatitis in a Patient Treated with the Tumor Necrosis Factor Inhibitor, Etanercept

et al. 2011

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We report a case of rheumatoid arthritis (RA) with autoimmune hepatitis (AIH) and Sjogren syndrome (SjS) that was treated with the tumor necrosis factor (TNF) inhibitor, etanercept (ETN). Both RA activity and transaminase levels improved as a result of treatment. Follow-up liver biopsy showed improvement of hepatitis. Although the efficacy of anti-TNF for RA patients with AIH remains controversial, this case suggests that treatment with ETN may result in a favorable clinical course in a certain subset of patients with RA and AIH.

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“…Various mechanisms have been postulated for chronic stimulation of B-cells by HCV. Elevated serum B-lymphocyte activating factor (BAFF) has been found in chronic HCV-infected subjects compared to healthy controls 7 . HCV-infected subjects with clinical and laboratory features of autoimmunity were found to have the highest levels of BAFF 8 .…”

Section: To the Editormentioning

confidence: 99%