Elevated Serum Bisphenol A Levels under Hyperandrogenic Conditions may be Caused by Decreased UDP-glucuronosyltransferase Activity

Takeuchi, Tōru; Tsutsumi, Osamu; Ikezuki, Yumiko; Kamei, Yoshimasa; Osuga, Yutaka; Fujiwara, Toshihiro; Takai, Yasushi; Momoeda, Mikio; Yano, Tetsu; Taketani, Yuji

doi:10.1507/endocrj.k06-032

Cited by 65 publications

(49 citation statements)

References 32 publications

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“…Two studies found women with polycystic ovarian syndrome (PCOS) had higher serum levels of BPA than did healthy control women (Takeuchi and Tsutsumi 2002;Takeuchi et al 2004). These studies also found a positive association between serum testosterone levels and BPA concentrations; this finding is especially interesting because it provides a potential basis for gender-biased exposures or metabolism of BPA (Takeuchi et al 2006).…”

Section: Healthymentioning

confidence: 72%

Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A

Vandenberg

Chahoud

Heindel³

et al. 2012

Ciênc. saúde coletiva

333

331

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Estudos de biomonitoração do sistema urinário, circulatório e tecidos indicam grande exposição ao Bisfenol A Resumo Bisfenol A (BPA) é um dos produtos quí-micos mais produzido em todo o mundo, e a exposição humana a ele é considerada onipresente. Assim, há preocupações de que a quantidade de BPA para o qual os seres humanos estão expostos podem causar efeitos adversos à saúde. Nós examinamos muitas possibilidades sobre o porquê estudos de biomonitorização e toxicocinética podem chegar a conclusões aparentemente conflitantes. Mais de 80 estudos publicados de biomonitorização humana que mediram a concentração de BPA em tecidos humanos, urina, sangue e outros fluidos, juntamente com dois estudos de toxicocinéti-ca do metabolismo humano BPA foram examinados. BPA não conjugado foi detectado no sangue (nonanogramas por mililitro gama), e BPA conjugado foi detectado na grande maioria das amostras de urina. Em contraste, estudos de toxico-cinética propuseram que os seres humanos não são internamente expostos ao BPA. Dados disponíveis de estudos de biomonitorização indicam que a população em geral está exposta ao BPA e em risco de exposição interna ao BPA não conjugado. Os dois estudos de toxicocinética, que sugeriram a exposição humana ao BPA é insignificante, têm deficiências significativas e estão diretamente refutados por outros estudos e, portanto não são confiáveis para fins de avaliação de risco. Palavras-chave Disruptor endócrino, Exposição humana, Modelo PBPK/PBTK, Gravidez, Avaliação de risco, Toxicocinética Abstract Bisphenol A (BPA) is one of the highest-volume chemicals produced worldwide, and human exposure to BPA is thought to be ubiquitous. Thus, there are concerns that the amount of BPA to which humans are exposed may cause adverse health effects. We examined many possibilities for why biomonitoring and toxicokinetic studies could come to seemingly conflicting conclusions. More than 80 published human biomonitoring studies that measured BPA concentrations in human tissues, urine, blood, and other fluids, along with two toxicokinetic studies of human BPA metabolism were examined. Unconjugated BPA was routinely detected in blood (in the nanograms per milliliter range), and conjugated BPA was routinely detected in the vast majority of urine samples (also in the nanograms per milliliter range). In stark contrast, toxicokinetic studies proposed that humans are not internally exposed to BPA. Available data from biomonitoring studies clearly indicate that the general population is exposed to BPA and is at risk from internal exposure to unconjugated BPA. The two toxicokinetic studies that suggested human BPA exposure is negligible have significant deficiencies, are directly contradicted by hypothesis-driven studies, and are therefore not reliable for risk assessment purposes.

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Section: Healthymentioning

confidence: 72%

Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A

Vandenberg

Chahoud

Heindel³

et al. 2012

Ciênc. saúde coletiva

333

331

View full text Add to dashboard Cite

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“…Also intriguing is the effect of BPA on one sex but not the other [45,46,48,58,66,[68][69][70][71][72][73]. The mechanisms responsible for different effects of BPA in males and females are not clear, although it is known that BPA metabolism is influenced by testosterone [74,75], and BPA modifies the metabolism of testosterone [41, 76,77]. Thus, one possibility is that the sex-specific effects of BPA in the brain and other tissues are due to an interaction with background levels of gonadal steroids.…”

Section: Behavioral Effectsmentioning

confidence: 99%

In vivo effects of bisphenol A in laboratory rodent studies

Richter

Birnbaum

Farabollini

et al. 2007

Reproductive Toxicology

1,039

733

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Concern is mounting regarding the human health and environmental effects of bisphenol A (BPA), a high-production-volume chemical used in synthesis of plastics. We have reviewed the growing literature on effects of low doses of BPA, below 50 mg/kg/day, in laboratory exposures with mammalian model organisms. Many, but not all, effects of BPA are similar to effects seen in response to the model estrogens diethylstilbestrol and ethinylestradiol. For most effects, the potency of BPA is approximately 10 to 1,000-fold less than that of diethylstilbestrol or ethinylestradiol. Based on our review of the literature, a consensus was reached regarding our level of confidence that particular outcomes occur in response to low-dose BPA exposure. We are confident that adult exposure to BPA affects the male reproductive tract, and that long-lasting, organizational effects in response to developmental exposure to BPA occur in the brain, the male reproductive system, and metabolic processes. We consider it likely, but requiring further confirmation, that adult exposure to BPA affects the brain, the female reproductive system, and the immune system, and that developmental effects occur in the female reproductive system.

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“…administration. [29][30][31] Corn oil has often been used as a solvent in administration of BPA, 10,22,32,33) and the bioavailability of hydrophobic compounds was improved by co-administration with oil. 34) The resulting level of BPA in the body in this study, in which deionized water was used basically as a matrix for administration, is thus considered to be lower than those in the experiments of other groups.…”

Section: Ova (µM)mentioning

confidence: 99%

Orally Administered Bisphenol A Disturbed Antigen Specific Immunoresponses in the Naïve Condition

Goto¹,

Takano-Ishikawa²,

Ono³

et al. 2007

Bioscience, Biotechnology, and Biochemistry

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Elevated Serum Bisphenol A Levels under Hyperandrogenic Conditions may be Caused by Decreased UDP-glucuronosyltransferase Activity

Cited by 65 publications

References 32 publications

Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A

Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A

In vivo effects of bisphenol A in laboratory rodent studies

Orally Administered Bisphenol A Disturbed Antigen Specific Immunoresponses in the Naïve Condition

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