Elevated Serum Creatine Kinase Level in Diabetic Patients with Nephrotic Syndrome: A Role of Fluid Retention

Taniyama, Matsuo; Yoh, Shisei; Asaba, Yoshiaki; Maruyama, Taro; Takei, Izumi; Kataoka, Kensuke

doi:10.7326/0003-4819-106-5-711

Cited by 5 publications

(3 citation statements)

References 2 publications

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“…Additionally, these biomarkers can be used to initially predict patient prognosis. However, previous studies have focused on peripheral blood markers, such as growth factors, enzymes, inflammatory responses, proteins, peptide chain precursors, and other macromolecular proteins [12-15]. Although such studies offer effective information for the early diagnosis and prognosis of AD and also provide constructive suggestions for AD pathogenesis elucidation, due to the intrinsic particularity of protein macromolecules, their dissemination in clinical detection for AD faces many challenges, including determining the preservation and testing conditions, diagnosis interval, and cost.…”

Section: Discussionmentioning

confidence: 99%

“…There has been significant progress made in the application of all types of biomarkers for the diagnosis and treatment of diseases, which is useful to clinicians, and molecules such as smMHC, CK-BB, and MMPs [14, 15] have been used in some clinical testing applications. However, there are issues with the application of these biomarkers, inhibiting their widespread implementation for clinical detection.…”

Section: Discussionmentioning

confidence: 99%

“…Additional protein molecules closely related to the development of AD have since been found. For instance, the level of lipoprotein (LP) is significantly higher in patients with AD than in patients with myocardial infarction or normal controls, possibly because LP facilitates inflammatory reactions in the arterial wall, thereby affecting its structure [15]. …”

Section: Introductionmentioning

confidence: 99%

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Serum Biomarker Identification by Mass Spectrometry in Acute Aortic Dissection

Ren

Tang

Liu

et al. 2017

Cell Physiol Biochem

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Background/Aims: Aortic dissection (AD) is also known as intramural hematoma. This study aimed to screen peripheral blood biomarkers of small molecule metabolites for AD using high-performance liquid chromatography-mass spectrometry (HPLC-MS). Methods: Sera from 25 healthy subjects, 25 patients with well-established AD, and 25 patients with well-established hypertension were investigated by HPLC-MS to detect metabolites, screen differentially expressed metabolites, and analyze metabolic pathways. Results: Twenty-six and four metabolites were significantly up- and down-regulated in the hypertensive patients compared with the healthy subjects; 165 metabolites were significantly up-regulated and 109 significantly down-regulated in the AD patients compared with the hypertensive patients. Of these metabolites, 35 were up-regulated and 105 down-regulated only in AD patients. The metabolites that were differentially expressed in AD are mainly involved in tryptophan, histidine, glycerophospholipid, ether lipid, and choline metabolic pathways. As AD alters the peripheral blood metabolome, analysis of peripheral blood metabolites can be used in auxiliary diagnosis of AD. Conclusion: Eight metabolites are potential biomarkers for AD, 3 of which were differentially expressed and can be used for auxiliary diagnosis of AD and evaluation of treatment effectiveness.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serum Biomarker Identification by Mass Spectrometry in Acute Aortic Dissection

Ren

Tang

Liu

et al. 2017

Cell Physiol Biochem

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Adenomatous ductal proliferation/hyperplasia in the parotid gland associated without any other pathological lesions; a report and survey of the literatures

et al. 2018

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Adenomatous ductal proliferation/hyperplasia (ADP/H) is a rare hyperplastic condition of the salivary gland. It is mostly associated with other salivary gland pathologies such as tumors and inflammations, and is incidentally found in tissue sections during histopathological examinations of those diseases. Herein, we report a case of ADP/H in the parotid gland not associated with any other pathological lesions, and present a review of the literature on this condition. A 60-year-old Japanese female complained of swelling on the left side of parotid region. Clinical examination revealed a swelling on the lower lobe of the left parotid gland. The lesion was firm but non-tender and was not attached to adjacent structures. A clinical diagnosis of benign salivary gland tumor was reached, and surgical excision was performed under general anesthesia. Histopathological examination revealed an intact parotid gland capsule with isomorphic and basaloid cells within scanty cytoplasm. In addition, an admixture of hyperplasia and proliferation of the intercalated ducts, the presence of zymogen granules, the absence of solid nests, and a peripheral palisaded arrangement of the cells were observed. Based on these findings, a diagnosis of ADP/H was confirmed. ADP/H is a non-tumorous lesion; therefore, tumor involvement should be ruled out before the diagnosis is reached.

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