Elevated serum dipeptidyl peptidase IV activity in patients with chronic tonsillitis

Abstract

An increased serum DPP IV activity was observed in TH patients compared with both RT patients and controls before tonsillectomy. After tonsillectomy, all activities were similar. The results suggest that serum DPP IV activity may have potential as a diagnostic marker for patients with TH.

Activity of soluble aminopeptidase A and dipeptidyl peptidase IV and membrane-bound aminopeptidase B and pyroglutamyl peptidase I in adenoid hyperplasia, tonsillar hyperplasia and chronic tonsillitis

“…The pattern of activity shown by these enzymes differed depending on patient age and gender as well as their medical condition. This selective pattern has also been described in previous studies [1,3,7] and demonstrates that the changes observed are not the result of nonspecific cell proteolysis.…”

“…In the present study, the soluble isoform of DPPIV showed a similar activity pattern, with statistically significant results when considering the gender of the patient with CT. Recently, Vlahović et al [1] demonstrated that DPPIV activity in serum is altered in patients with CT and TH, and normalizes after tonsillectomy. They also reported that the level of DPPIV in serum from individuals with CT was higher in younger patients.…”

Dipeptidyl peptidase IV (DPP4) deficiency increases Th1-driven allergic contact dermatitis

“…Furthermore, increased CD26 expression has also been reported for other inflamed tissues, e.g. palatine tonsils [28] in humans and allergic-like airway inflammation in rats [18]. However, to our knowledge, this is the first report of enhanced CD26 expression in AD and CD lesions.…”

Sitagliptina, un inhibidor de la enzima DPP-IV, aumenta el colesterol plasmático total, altera el perfil de colesterol lipoproteico y disminuye el transporte reverso de colesterol en ratones

“…Para evaluar el efecto directo de la sitagliptina sobre su blanco farmacológico, se cuantificó la actividad de la enzima DPP-IV en el plasma de animales controles y tratados a través de la conversión de Gly-Pro p-nitroanilida a p-nitroanilina. La formación de p-nitroanilina se midió espectrofotométricamente (390 nm) a distintos tiempos 34 . La actividad del grupo tratado con sitagliptina se expresó en forma relativa a la actividad de los animales controles.…”