Elevated Serum Growth Hormone in Protein-Deprived Rats, and Decreased Liver RNA after Hypophysectomy

Christensson, Per-Inge; Rerup, Claus; Seyer‐Hansen, K.; Stenram, Unne

doi:10.1515/bchm2.1975.356.1.591

Cited by 3 publications

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“…However, the indirect evidence from several studies cited below and the direct evidence from one study (Christensson et al 1975) to be discussed makes this inter pretation of the present findings an unlikely one.…”

Section: A Suppression Of Polyploidizationmentioning

confidence: 65%

“…Insufficient data are presently available to determine whether the hepatic response may have been sufficiently altered in animals fed 5% protein to attenuate a growth hormone-mediated tetraploidization. In hypophysectomized rats (100 grams) fed a non-protein diet for 5 days, growth hormone increased the liver RNA/DNA ratio toward control values but combined growth hormone, hydrocortisone and triiodothyronine therapy were necessary to restore values to those of controls (Christensson et al 1975). …”

Section: A Suppression Of Polyploidizationmentioning

confidence: 99%

“…Although increased growth hormone may be a temporal correlate of tetraploidization, recent evidence for the rat suggested that circulating levels of the hormone were increased rather than decreased following 14 days on a non-protein diet (Christensson et al 1975). …”

Section: A Suppression Of Polyploidizationmentioning

confidence: 99%

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Ploidy and biochemical characteristics of liver cell nuclei in rats fed different amounts of dietary protein

Moore

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Section: A Suppression Of Polyploidizationmentioning

confidence: 65%

Section: A Suppression Of Polyploidizationmentioning

confidence: 99%

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Ploidy and biochemical characteristics of liver cell nuclei in rats fed different amounts of dietary protein

Moore

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“…was suggested by Mulinos and Pomerantz (1941) to explain the similarities in severely undernourished and hypophysectomized animals. However, the indirect evidence from several studies cited below and the direct evidence from one study (Christensson et al 1975) to be discussed makes this inter pretation of the present findings an unlikely one.…”

Section: A Suppression Of Polyploidizationmentioning

confidence: 67%

“…The findings of Blazquez et al (1974) and Strosser and Mialhe (1975) both suggested gradual elevations in serum rat growth hormone during the post-veaning period and up to 80 days of age. Although increased growth hormone may be a temporal correlate of tetraploidization, recent evidence for the rat suggested that circulating levels of the hormone were increased rather than decreased following 14 days on a non-protein diet (Christensson et al 1975).…”

Section: A Suppression Of Polyploidizationmentioning

confidence: 99%

Ploidy and biochemical characteristics of liver cell nuclei in rats fed different amounts of dietary protein

Moore

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of analysis of variance for data 165 on hepatic DNA concentration (mg/g liver) in experiment III. XIII. Summary of analysis of variance for data 165 on hepatic RNA concentration (mg/g liver) in experiment II. XXV. Summary of analysis of variance for data 167 on hepatic RNA concentration (mg/g liver) in experiment III. XV. Summary of analysis of variance for data 158 on hepatic protein concentration (mg/g liver) in experiment II.

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Effect of hypophysectomy on the stimulation of liver growth by ?-hexachlorocyclohexane, phenobarbital, and partial hepatectomy in the rat

Schulte‐Hermann

Landgraf

Koransky

1977

Naunyn-Schmiedeberg's Arch. Pharmacol.

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alpha-Hexachlorocyclohexane (alpha-HCH) or phenobarbital (PB) elicit growth and cell multiplication in rat liver. In hypophysectomized rats, alpha-HCH and PB induce an increase in liver mass, but no increase in liver DNA. Hypophysectomy without additional treatment results in a decrease of liver size and RNA, while the DNA content remains unchanged, thereby leading to a relative DNA surplus. 1/3-hepatectomy in hypophysectomized animals leads to a small increase of hepatic DNA only; after 2/3-hepatectomy 75-80% of the original liver DNA are restored. In rats with intact hypophysis losses of liver DNA are known to be restored completely. The findings suggest that the relative DNA surplus in hypophysectomized rats prevents the stimulation of DNA synthesis by weak growth stimuli such as alpha-HCH, PB, and 1/3-hepatectomy. If the relative DNA surplus is eliminated by partial hepatectomy, the inducers do produce DNA multiplication. It is concluded that the induction of liver growth and cell multiplication by alpha-HCH and PB does not require the presence of the hypophysis or one of its hormones.

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Elevated Serum Growth Hormone in Protein-Deprived Rats, and Decreased Liver RNA after Hypophysectomy

Cited by 3 publications

References 0 publications

Ploidy and biochemical characteristics of liver cell nuclei in rats fed different amounts of dietary protein

Ploidy and biochemical characteristics of liver cell nuclei in rats fed different amounts of dietary protein

Ploidy and biochemical characteristics of liver cell nuclei in rats fed different amounts of dietary protein

Effect of hypophysectomy on the stimulation of liver growth by ?-hexachlorocyclohexane, phenobarbital, and partial hepatectomy in the rat

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