Elevated serum homocysteine levels in male patients with PTSD

Abstract

It has been suggested that an elevated serum or plasma homocysteine level may be a risk factor for neuropsychiatric conditions such as Alzheimer's disease, schizophrenia, and depression. Because depression is closely related to anxiety disorders, and because it has been suggested that stress may be associated with an elevated homocysteine level, we studied whether serum homocysteine levels are elevated in patients with posttraumatic stress disorder (PTSD). Total serum homocysteine levels in 28 male patients with PTSD were compared to those of 223 healthy controls. The effect of PTSD on the serum homocysteine level was significant (F=42.96, P<.0001). In a regression model for the PTSD patients, the duration of PTSD was found to predict serum homocysteine levels (t=2.228, P=.035). Our results suggest that elevated levels of homocysteine in male patients with PTSD may be related to pathophysiological aspects associated with the chronicity of this disorder.

Cardiovascular Disease Risk Factors in Patients With Posttraumatic Stress Disorder (Ptsd): A Narrative Review

“…Increased homocysteine levels were detected in non-smoking PTSD patients in a study on 66 Croatian war veterans, while there were no differences in serum lipid levels between war veterans and controls (Jendri ko et al 2009). In addition, increased serum homocysteine levels were also reported in 28 male patients with PTSD (Levine et al 2008). In this study, the duration of PTSD symptoms predicted serum homocysteine levels (Levine et al 2008).…”

“…In addition, increased serum homocysteine levels were also reported in 28 male patients with PTSD (Levine et al 2008). In this study, the duration of PTSD symptoms predicted serum homocysteine levels (Levine et al 2008). …”

Postural Control in Patients After a Recent Vestibular Neuritis with Hyperhomocysteinemia

“…Finally, HyHcy has been associated with depression and partially with anxiety and these findings do not correlate with the age of subjects; moreover, HyHcy has been correlated with the possibility of chronicization of emotional disorders in a sample of male adults [28,29].…”

The history of childhood trauma is associated with lipid disturbances and blood pressure in adult first-episode schizophrenia patients

“…To date, there are two studies showing the relationship between PTSD and elevated Hcy levels [31,32]. However, we failed to find the association between childhood adversities and Hcy levels in FES patients.…”