Elevated serum interferon γ and interleukin‐6 in patients with necrotizing lymphadenitis (Kikuchi's disease)

Kubota, Masaru; Tsukamoto, Reiko; Kurokawa, Keiji; Imai, Tsuyoshi; Furusho, Kenshi

doi:10.1046/j.1365-2141.1996.d01-1964.x

Cited by 58 publications

(34 citation statements)

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“…A number of inflammatory mediators have been associated with KFD or AOSD individually, including IL-6, IL-18, and IFN-γ [24,25]. Although IL-1β has been Marked improvement Lyberatos [11] 18, M, race not reported Steroids Asymptomatic at 3 months Lyberatos [11] 47, F, race not reported Aspirin Asymptomatic Ohta et al [10] 41, M, Japanese NSAIDs No response Steroids…”

Section: Discussionmentioning

confidence: 99%

Co-occurrence of Kikuchi-Fujimoto’s disease and Still’s disease: case report and review of previously reported cases

Toribio

Kamino

et al. 2014

Clin Rheumatol

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Kikuchi-Fujimoto's disease (KFD) and adult-onset Still's disease (AOSD) are rare inflammatory conditions with some overlapping features. We encountered a 22-year-old male patient who presented with daily fevers, neck discomfort, and sore throat and subsequently developed rash, arthritis, and cervical lymphadenopathy. Biopsy of the skin rash was consistent with KFD skin involvement. Given that the patient also met criteria for AOSD, a final diagnosis of KFD/AOSD co-occurrence was made. Anti-IL-1β therapy with anakinra resulted in rapid resolution of all symptoms. A literature search identified eight more cases of KFD/AOSD. Fever, rash, arthritis, and lymphadenopathy were present in all patients. No case report demonstrated an association of rash eruption clearly associated with fever spikes. Duration of symptoms ranged from 3 weeks to 10 years. Seven patients had leukocytosis, six had anemia, and five demonstrated elevated ferritin and/or decreased glycosylated ferritin. Seven patients had elevated erythrocyte sedimentation rate (ESR), and seven had transaminitis. Eight of nine patients had no evidence of infectious disease. Autoantibodies were absent from all patients. KFD and AOSD are very rare diseases, yet they may overlap. The two conditions not only share several clinical and laboratory characteristics but also differ in characteristic ways. Given the rapid response observed with anakinra in the index patient, IL-1β likely plays a role in both diseases.

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Section: Discussionmentioning

confidence: 99%

Co-occurrence of Kikuchi-Fujimoto’s disease and Still’s disease: case report and review of previously reported cases

Toribio

Kamino

et al. 2014

Clin Rheumatol

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“…İyileşme döneminde de İNF-g ve İL-6 değerleri tekrar düşüş göstermiştir. [12] Daha sonraki çalışmalar da bu bulguları desteklemektedir. [13] Kikuchi-Fujimoto hastalığı ile sistemik lupus eritematöz (SLE) arasında birliktelik bildiren yazarlar vardır.…”

Section: Discussionunclassified

Kikuchi-Fujimoto disease

Lebe

2014

Kulak Burun Bogaz Ihtis Derg

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“…'ı hastalığın akut fazında yükselen ve iyileşme döneminde normale dönen serum interferon-gamma ve interlökin-6 düzeyleri, Kato ve ark. 'ı ise "soluble" Fas ligand düzeyleri bildirmişlerdir 15,16 . En sık klinik yansıma ağrısız veya hafif hassas olabilen ve sıklıkla ateşin eşlik ettiği tek taraflı posterior servikal lenfadeopatidir.…”

Section: Discussionunclassified

Kikuchi hastalığı ve sistemik lupus eritematoz: olgu sunumu

Özmen¹,

Altıner²,

Topçugil³

et al. 2014

TURKDERM

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Kikuchi hastalığı (KH) ateş, servikal lenfadenopati ve lökopeni ile karakterize iyi huylu ve kendini sınırlayan nadir bir hastalıktır. Benzer klinik ve histolojik özelliklere sahip oldukları için KH'nın, tedavi ve prognozu tamamen farklı olan sistemik lupus eritematoz (SLE), tüberküloz ve lenfoma ile ayırıcı tanısı yapılmalıdır. Ayrıca nadir olarak KH ve SLE birlikte görülebilir. Bu olgu sunumunda KH ve SLE tanılarını eş zamanlı almış olan bir kadın hasta sunulmaktadır. (Türk derm 2014; 48: 47-50) Anah tar Ke li me ler: Kikuchi hastalığı, sistemik lupus eritematoz, lenfadenopati, romatizmal hastalıklar Sum maryKikuchi disease (KD) is a rare, benign and self-limited condition characterized by fever, cervical lymphadenopathy and leukopenia. The differential diagnosis of KD should include systemic lupus erythematosus (SLE), tuberculosis and lymphoma because of similar clinical and histological features and entirely different treatment and prognosis. KD and SLE may present together. In this case report, we present a female patient who was diagnosed with KD and SLE simultaneously. (Turkderm 2014; 48: 47-50)

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Elevated serum interferon γ and interleukin‐6 in patients with necrotizing lymphadenitis (Kikuchi's disease)

Cited by 58 publications

References 0 publications

Co-occurrence of Kikuchi-Fujimoto’s disease and Still’s disease: case report and review of previously reported cases

Co-occurrence of Kikuchi-Fujimoto’s disease and Still’s disease: case report and review of previously reported cases

Kikuchi-Fujimoto disease

Kikuchi hastalığı ve sistemik lupus eritematoz: olgu sunumu

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