Elevated serum level of interleukin‐15 in vitiligo patients and its correlation with disease severity but not activity

Atwa, Mona; Ali, Sara Mohammed Mohammed; Youssef, Nahed; Marie, Radwa El‐Sayed Mahmoud

doi:10.1111/jocd.13908

Cited by 20 publications

(24 citation statements)

References 27 publications

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“…Results of that study revealed that serum IL-15 level, in patients with vitiligo, was significantly higher in comparison with the control group (P=0.001). Also, a significant positive correlation was found between serum IL-15 level and VES score (P=0.001), whereas there was no significant correlation between IL-15 level and VIDA score as well as the disease duration (19) .…”

Section: Discussionmentioning

confidence: 84%

Serum Interleukin-15 in Egyptian Vitiligo Patients

Eladl¹,

Galal²,

El-tantawy³

et al. 2021

The Egyptian Journal of Hospital Medicine

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Background: Vitiligo is a multifactorial acquired depigmenting skin disorder with poorly understood etiology. It is characterized by white macules and patches due to loss of functioning epidermal melanocytes. The most widely accepted hypothesis is the autoimmune-mediated melanocyte destruction through the interplay between cellular immunity, humoral immunity, and cytokine action. Peri-lesional vitiligo skin biopsies revealed CD8+ cytotoxic T (cT) cell infiltration proposing a cytotoxic attack against melanocytes. It has been hypothesized that IL-15 might play a role in this autoimmune disease; thus, inhibiting IL-15 activity might be a breaking new therapeutic strategy in the treatment of vitiligo. Objective: The current study was conducted to assess the serum level of IL-15 in patients with non-segmental vitiligo, and to correlate its levels with disease duration, extent, and activity. Patients and methods: The present study was a case-control study conducted on three groups of subjects attending the Dermatology Outpatient Clinic in Mansoura University Hospitals: 30 patients suffering from active non-segmental vitiligo, 30 patients with stable non-segmental vitiligo, and 30 age-and sex-matched healthy controls. Results: Healthy controls and vitiligo cases demonstrated insignificant differences in terms of the demographic characteristics as well as the risk factors. IL-15 level demonstrated insignificant correlation with the gender, smoking, stress, and clinical type in both vitiligo groups. Higher IL-15 level was suggested to be independent risk predictor for vitiligo occurrence and severity but not activity. Conclusion: It could be concluded that, vitiligo cases were associated with a significant elevation in IL-15 level.

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Section: Discussionmentioning

confidence: 84%

Serum Interleukin-15 in Egyptian Vitiligo Patients

Eladl¹,

Galal²,

El-tantawy³

et al. 2021

The Egyptian Journal of Hospital Medicine

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show abstract

“…It has been established that IL-15 seems to participate in IL-17 regulation and maintenance of TRM signals (80), with the latter responsible for long-term maintenance and potential relapse of vitiligo (81). The study has demonstrated a higher serum level of IL-15 in vitiligo patients than in controls, highly associated with epidermal H 2 O 2 content and the disease activity (82,83).…”

Section: Il-15 and The Inhibitorsmentioning

confidence: 97%

Advances in vitiligo: Update on therapeutic targets

Feng

Lü

2022

Front. Immunol.

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Vitiligo, whose treatment remains a serious concern and challenge, is an autoimmune skin disease characterized by patches of depigmentation. The increasing application of molecular-targeted therapy in skin diseases, such as psoriasis and systemic lupus erythematosus, has dramatically improved their condition. Besides, there is a favorable effect of repigmentation in the treatment of the above diseases combined with vitiligo, implying that molecular-targeted therapy may also have utility in vitiligo treatment. Recently, the role of cytokine and signaling pathways in vitiligo pathogenesis are increasingly recognized. Thus, investigations are underway targeting the molecules described above. In this paper, we present a synopsis of current practices in vitiligo treatment and introduce the improvement in identifying new molecular targets and applying molecular-targeted therapies, including those under development in vitiligo treatment, providing valuable insight into establishing further precision medicine for vitiligo patients.

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“…IL-15 expression in the epidermis and serum of patients with vitiligo was significantly higher when compared with healthy controls, and highly correlated with H 2 O 2 levels [ 68 ]. Oxidative stress promoted IL-15 and IL-15Rα expression, and also IL-15 trans-presentation by activating NF-κB signaling in keratinocytes, thereby contributing to effector memory T cell (CD 8 + T EM ) activation by IL-15-JAK-STAT signaling pathway [ 69 ].…”

Section: Oxidative Stress Stimulates Damp Release and Worsens Vitiligomentioning

confidence: 99%

Damage-associated molecular patterns in vitiligo: igniter fuse from oxidative stress to melanocyte loss

et al. 2022

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Objectives The pathogenesis of vitiligo remains unclear. In this review, we comprehensively describe the role of damage associated molecular patterns (DAMPs) during vitiligo pathogenesis. Methods Published papers on vitiligo, oxidative stress and DAMPs were collected and reviewed via database searching on PubMed, MEDLINE and Embase, etc. Results Oxidative stress may be an important inducer of vitiligo. At high oxidative stress levels, damage-associated molecular patterns (DAMPs) are released from keratinocytes or melanocytes in the skin and induce downstream immune responses during vitiligo. Treatment regimens targeting DAMPs can effectively improve disease severity. Discussion DAMPs play key roles in initiating host defenses against danger signals, deteriorating the condition of vitiligo. DAMP levels in serum and skin may be used as biomarkers to indicate vitiligo activity and prognosis. Targeted therapies, incorporating HMGB1, Hsp70, and IL-15 could significantly improve disease etiology. Thus, novel strategies could be identified for vitiligo treatment by targeting DAMPs.

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Elevated serum level of interleukin‐15 in vitiligo patients and its correlation with disease severity but not activity

Cited by 20 publications

References 27 publications

Serum Interleukin-15 in Egyptian Vitiligo Patients

Serum Interleukin-15 in Egyptian Vitiligo Patients

Advances in vitiligo: Update on therapeutic targets

Damage-associated molecular patterns in vitiligo: igniter fuse from oxidative stress to melanocyte loss

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