Elevated serum levels of AGEs, sRAGE, and pentosidine in Tunisian patients with severity of diabetic retinopathy

Kerkeni, Mohsen; Saidi, Amel; Bouzidi, Hassan; Yahya, Slim Ben; Hammami, Mohamed

doi:10.1016/j.mvr.2012.07.006

Cited by 45 publications

(35 citation statements)

References 50 publications

(39 reference statements)

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“…The baseline AGEs and sRAGE levels observed in our sample were higher than in a population of healthy individuals of comparable age and ethnicity who were not chronically exercising intensively [30]. In this report of Kerkeni et al, 30 healthy subjects showed average serum AGE of 508.83 ± 119.68 pg/mL and average serum sRAGE of 148.72 ± 32.73 pg/mL.…”

Section: Discussioncontrasting

confidence: 48%

Curcumin and Boswellia serrata Modulate the Glyco-Oxidative Status and Lipo-Oxidation in Master Athletes

et al. 2016

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Background: Chronic intensive exercise is associated with a greater induction of oxidative stress and with an excess of endogenous advanced glycation end-products (AGEs). Curcumin can reduce the accumulation of AGEs in vitro and in animal models. We examined whether supplementation with curcumin and Boswellia serrata (BSE) gum resin for 3 months could affect plasma levels of markers of oxidative stress, inflammation, and glycation in healthy master cyclists. Methods. Forty-seven healthy male athletes were randomly assigned to Group 1, consisting of 22 subjects given a Mediterranean diet (MD) alone (MD group), and Group 2 consisted of 25 subjects given a MD plus curcumin and BSE (curcumin/BSE group). Interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), high-sensitivity c-reactive protein (hs-CRP), total AGE, soluble receptor for AGE (sRAGE), malondialdehyde (MDA), plasma phospholipid fatty acid (PPFA) composition, and non-esterified fatty acids (NEFA) were tested at baseline and after 12 weeks. Results: sRAGE, NEFA, and MDA decreased significantly in both groups, while only the curcumin/BSE group showed a significant decline in total AGE. Only the changes in total AGE and MDA differed significantly between the curcumin/BSE and MD groups. Conclusions. Our data suggest a positive effect of supplementation with curcumin and BSE on glycoxidation and lipid peroxidation in chronically exercising master athletes.

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Section: Discussioncontrasting

confidence: 48%

Curcumin and Boswellia serrata Modulate the Glyco-Oxidative Status and Lipo-Oxidation in Master Athletes

et al. 2016

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“…Bone pentosidine levels are related to the strength of the human vertebra, independent of BMD [73]. Increased levels of serum pentosidine, AGEs, and soluble receptors for advanced glycation end products (sRAGE) were reported in type 2 diabetes compared with controls [75, 76]. Serum pentosidine was associated with greater risk of vertebral fracture in patients with type 2 diabetes [77], while urinary pentosidine is associated with an increased risk of clinical and vertebral fractures [78, 79].…”

Section: Bone Turnover: Histomorphometry and Serum Markersmentioning

confidence: 99%

Diagnosis and management of bone fragility in diabetes: an emerging challenge

et al. 2018

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Fragility fractures are increasingly recognized as a complication of both type 1 and type 2 diabetes, with fracture risk that increases with disease duration and poor glycemic control. Yet the identification and management of fracture risk in these patients remains challenging. This review explores the clinical characteristics of bone fragility in adults with diabetes and highlights recent studies that have evaluated bone mineral density (BMD), bone microstructure and material properties, biochemical markers, and fracture prediction algorithms (i.e., FRAX) in these patients. It further reviews the impact of diabetes drugs on bone as well as the efficacy of osteoporosis treatments in this population. We finally propose an algorithm for the identification and management of diabetic patients at increased fracture risk.

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“…In addition to their endogenous formation, AGEs exist in high amounts in cooked fast-food diet and known by brown coloration, but only a small quantity of these compounds present in food are absorbed and the other part is secreted by the kidneys in urine [5]. However, pentosidine and ε -N-carboxymethyl-l-lysine (CML) have been well characterized as biomarkers for the formation and accumulation of AGEs [6] and are known to play an important role in diabetes and vascular complications [7–9]. AGEs cause damage by affecting protein structure, by formation of cross-links between molecules, or by binding the receptor for AGEs (RAGE) [10–12].…”

Section: Introductionmentioning

confidence: 99%

Plasma Levels of Pentosidine, Carboxymethyl-Lysine, Soluble Receptor for Advanced Glycation End Products, and Metabolic Syndrome: The Metformin Effect

Haddad

Knani

Bouzidi³

et al. 2016

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Metabolic syndrome (MetS) is considered one of the most important public health problems. Several and controversial studies showed that the role of advanced glycation end products (AGEs) and their receptor in the development of metabolic syndrome and therapeutic pathways is still unsolved. We have investigated whether plasma pentosidine, carboxymethyl-lysine (CML), and soluble receptor for advanced glycation end products (sRAGE) levels were increased in patients with MetS and the effect of metformin in plasma levels of pentosidine, CML, and sRAGE. 80 control subjects and 86 patients were included in this study. Pentosidine, CML, and sRAGE were measured in plasma by enzyme-linked immunosorbent assay (ELISA). Plasma pentosidine, CML, and sRAGE levels were significantly increased in patients compared to control subjects (P < 0.001, P < 0.001, and P = 0.014, resp.). Plasma levels of pentosidine were significantly decreased in patients who received metformin compared to untreated patients (P = 0.01). However, there was no significant difference between patients treated with metformin and untreated patients in plasma CML levels. Plasma levels of sRAGE were significantly increased in patients who received metformin and ACE inhibitors (P < 0.001 and P = 0.002, resp.). However, in a multiple stepwise regression analysis, pentosidine, sRAGE, and drugs treatments were not independently associated. Patients with metabolic syndrome showed increased levels of AGEs such as pentosidine and CML. Metformin treatment showed a decreased level of pentosidine but not of CML. Therapeutic pathways of AGEs development should be taken into account and further experimental and in vitro studies merit for advanced research.

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Elevated serum levels of AGEs, sRAGE, and pentosidine in Tunisian patients with severity of diabetic retinopathy

Cited by 45 publications

References 50 publications

Curcumin and Boswellia serrata Modulate the Glyco-Oxidative Status and Lipo-Oxidation in Master Athletes

Curcumin and Boswellia serrata Modulate the Glyco-Oxidative Status and Lipo-Oxidation in Master Athletes

Diagnosis and management of bone fragility in diabetes: an emerging challenge

Plasma Levels of Pentosidine, Carboxymethyl-Lysine, Soluble Receptor for Advanced Glycation End Products, and Metabolic Syndrome: The Metformin Effect

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