Elevated serum levels of alanine aminotransferase and gamma glutamyltransferase are markers of inflammation and oxidative stress independent of the metabolic syndrome

Yamada, Jiko; Tomiyama, Hirofumi; Yambe, Minoru; Koji, Yutaka; Motobe, Kohki; Shiina, Kazuki; Yamamoto, Yoshio; Yamashina, Akira

doi:10.1016/j.atherosclerosis.2005.11.036

Cited by 214 publications

(165 citation statements)

References 32 publications

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“…Serum -GTP level is a maker of oxidative stress and inflammation, both of which can play a role in the pathophysiology of CVD 2,3) . Moreover, -GTP may trigger oxidation of low-density lipoproteins and contribute to plaque formation, maturation, and rupture 23,24) .…”

Section: Exposure and Cvd Outcomesmentioning

confidence: 99%

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Serum γ-glutamyltransferase and Mortality due to Cardiovascular Disease in Japanese Men and Women

Iso

Cui

et al. 2016

J Atheroscler Thromb

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Aim:Whether the association between serum -glutamyltransferase ( -GTP) levels and total cardiovascular disease (CVD) mortality is independent of alcohol drinking in East Asian populations is not well known. We conducted a pooled analysis of Japanese men and women that enabled an analysis restricted to never-drinkers. Methods: A total of 15,987 men and 25,053 women aged 40-79 years, pooled from seven cohort studies throughout Japan, were followed-up to examine sex-specific relationship between serum -GTP levels and total CVD mortality. Cox regression model was used that was adjusted for age, smoking status, body mass index, and systolic blood pressure and serum triglyceride, total cholesterol, aspartate aminotransferase, and alanine aminotransferase levels. Results: During an average follow-up of 8.7 years, we documented 361 and 340 deaths from total CVD, 146 and 168 from stroke, and 101 and 53 from coronary heart disease (CHD) for men and women, respectively. Among the never-drinkers, hazard ratios (HRs) for mortality for one standard deviation of log--GTP for men were 1.89 (1.00-3.58) for stroke, 1.04 (0.57-1.90) for CHD, and 1.43 (1.04-1.96) for total CVD. For women, HRs were 1.28 (1.06-1.54), 1.81 (1.34-2.44), and 1.30 (1.14-1.49), respectively. Conclusion: -GTP may be a risk factor for total CVD mortality independent of alcohol drinking status in Japanese men and women.

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Section: Exposure and Cvd Outcomesmentioning

confidence: 99%

“…It has also been considered as a potential marker for oxidative stress and inflammation 2,3) . A previous meta-analysis showed that serum -GTP levels were positively associated with cardiovascular disease (CVD) risks in both men and women even within the normal range 4) .…”

Section: Introductionmentioning

confidence: 99%

Serum γ-glutamyltransferase and Mortality due to Cardiovascular Disease in Japanese Men and Women

Iso

Cui

et al. 2016

J Atheroscler Thromb

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“…It has been observed that elevated serum GGT is an independent marker of the activation of systemic inflammation and increased oxidative stress, independent of its relationship with metabolic syndrome 22) . Based on current available data, it has recently been purported that an increase in serum levels of GGT, although within its reference range, is a promising predictor of cardiovascular risk 21,[23][24][25][26] .…”

Section: Pathogenetic Rolementioning

confidence: 99%

Gamma-glutamyltransferase to Determine Cardiovascular Risk: Shifting the Paradigm Forward

Turgut

Tandoğan

2011

JAT

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Gamma-glutamyltransferase (GGT), regarded as a marker of excessive alcohol consumption or liver disturbances, is an enzyme catalyzing the first step in the extracellular degradation of the antioxidant glutathione (GSH) and may take part in atherogenesis. The marked relationship between GGT and the atherosclerotic process has shifted attention to the issue of whether its serum levels can aid in the detection of individuals at high risk for incident cardiovascular events. It is likely that the process entails the oxidation of low-density lipoprotein through GSH/GGT-dependent iron reduction within the plaque. In this context, oxidative stress is a probable mediator. Recent insights into the pathophysiological background of GGT in the precipitation and progression of atherosclerosis appear to be supported by relevant epidemiological observations as a cardiovascular risk predictor. Further understanding is, nevertheless, warranted to ameliorate the prognostic stratification of patients through GGT.

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“…In this process, g-GTP generates ROS, including superoxide and hydrogen peroxide (16,17). It was reported that circulating g-GTP activity is positively associated with oxidative stress markers, such as nitrotyrosine and lipid peroxide (28)(29)(30). Furthermore, it was shown that C-reactive protein, an inflammatory marker, is positively associated with circulating g-GTP activity in healthy subjects and in patients with acute coronary syndrome (31,32).…”

Section: Discussionmentioning

confidence: 99%

Circulating Interleukin-1^|^beta; Concentrations Are Independently-Positively Associated with ^|^gamma;-Glutamyltransferase Activity within the Normal Range in Middle-Aged Apparently Healthy Japanese Women

Yamazaki

Mochizuki

Miyauchi

et al. 2013

J Nutr Sci Vitaminol

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Elevated serum levels of alanine aminotransferase and gamma glutamyltransferase are markers of inflammation and oxidative stress independent of the metabolic syndrome

Cited by 214 publications

References 32 publications

Serum γ-glutamyltransferase and Mortality due to Cardiovascular Disease in Japanese Men and Women

Serum γ-glutamyltransferase and Mortality due to Cardiovascular Disease in Japanese Men and Women

Gamma-glutamyltransferase to Determine Cardiovascular Risk: Shifting the Paradigm Forward

Circulating Interleukin-1^|^beta; Concentrations Are Independently-Positively Associated with ^|^gamma;-Glutamyltransferase Activity within the Normal Range in Middle-Aged Apparently Healthy Japanese Women

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