Elevated serum levels of ghrelin and TNF-α in patients with cyanotic and acyanotic congenital heart disease

Zhang, Sai; Guo, Guimei; Yang, Lili; Sun, Liqun

doi:10.1007/s12519-016-0068-0

Cited by 10 publications

(7 citation statements)

References 33 publications

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“…Non‐CHD adults with HF reportedly have much lower ghrelin levels than those without HF . Moreover, plasma ghrelin levels are significantly high in children with CHD . Elevated ghrelin levels in these children might be related to malnutrition, growth retardation, and chronic shunt‐induced hypoxemia, wherein increased ghrelin might be a compensatory mechanism .…”

Section: Discussionmentioning

confidence: 99%

“…24,29 Moreover, plasma ghrelin levels are significantly high in children with CHD. [8][9][10][11][12][13] Elevated ghrelin levels in these children might be related to malnutrition, growth retardation, and chronic shunt-induced hypoxemia, wherein increased ghrelin might be a compensatory mechanism. [8][9][10][11][12][13] In contrast, the mechanism underlying low ghrelin levels in adult patients with Fontan circulation and those with cyanosis is likely distinct.…”

Section: Ghrelin and Heart Failurementioning

confidence: 99%

“…Ghrelin and leptin are important appetite‐related hormones that control appetite. Reportedly, plasma ghrelin levels are significantly high in infants and children with CHD . An elevated ghrelin level, which has a favorable effect on growth, might be a compensatory mechanism for malnutrition and growth retardation in these patients .…”

Section: Introductionmentioning

confidence: 98%

“…Reportedly, plasma ghrelin levels are significantly high in infants and children with CHD. [8][9][10][11][12][13] An elevated ghrelin level, which has a favorable effect on growth, might be a compensatory mechanism for malnutrition and growth retardation in these patients. [8][9][10][11] Moreover, promising results with several ghrelin agonists have already been reported in animal models of HF-related body wasting.…”

Section: Introductionmentioning

confidence: 99%

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Body composition, appetite-related hormones, adipocytokines, and heart failure in adult patients with congenital heart disease: A preliminary study

Shiina

Murakami

Matsumoto

et al. 2017

Congenital Heart Disease

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Objectives: To assess body composition and relationships among body composition, appetiterelated hormones, adipocytokines, and heart failure (HF) in adult patients with congenital heart disease (CHD).Patients: This prospective study enrolled 46 consecutive adult patients with CHD and 12 agematched healthy controls. The patients and control subjects were divided into four groups: 13 patients with Fontan circulation (group A), 16 patients with cyanosis (group B), 17 patients who previously underwent biventricular repair (group C), and 12 age-matched healthy controls.Design: Body composition was measured using InBody730, and levels of appetite-related hormones (ghrelin and leptin) and adipocytokines (leptin, interleukin-6, and tumor necrosis factor-a) were determined. Relationships of these measurements between severe HF, defined as New York Heart Association functional class III-IV and/or recent repeated unscheduled hospitalizations due to HF, were examined using univariate logistic analysis.Results: Mean patient age was 32.1 6 7.4 years. The skeletal muscle mass was significantly decreased in groups A and B compared with that in controls. Interestingly, ghrelin levels in groups A and B were also significantly lower than those in controls. Univariate logistic analysis revealed that ghrelin level, percent body fat, and pulse oximetric oxygen saturation were significantly associated with severe HF. Conclusions:Patients with Fontan circulation and those with cyanosis might be at a risk of sarcopenia. Despite the decreased skeletal muscle mass and increased body fat, ghrelin levels in these patients were decreased. These changes might have a negative impact on HF in these patients.

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Section: Discussionmentioning

confidence: 99%

Section: Ghrelin and Heart Failurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Body composition, appetite-related hormones, adipocytokines, and heart failure in adult patients with congenital heart disease: A preliminary study

Shiina

Murakami

Matsumoto

et al. 2017

Congenital Heart Disease

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“…Major factors contributing to growth retardation in infants with SV include inadequate caloric intake, high metabolic demand [ 27 , 28 ], hypoxemia [ 29 , 30 ], altered gastrointestinal physiology, and coexistent genetic and extracardiac abnormalities.…”

Section: The Burden Of Faltering Growth In Patients With Fontan Circu...mentioning

confidence: 99%

Nutritional Management of Patients with Fontan Circulation: A Potential for Improved Outcomes from Birth to Adulthood

et al. 2022

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Fontan circulation (FC) is a surgically achieved palliation state offered to patients affected by a wide variety of congenital heart defects (CHDs) that are grouped under the name of univentricular heart. The procedure includes three different surgical stages. Malnutrition is a matter of concern in any phase of life for these children, often leading to longer hospital stays, higher mortality rates, and a higher risk of adverse neurodevelopmental and growth outcomes. Notwithstanding the relevance of proper nutrition for this subset of patients, specific guidelines on the matter are lacking. In this review, we aim to analyze the role of an adequate form of nutritional support in patients with FC throughout the different stages of their lives, in order to provide a practical approach to appropriate nutritional management. Firstly, the burden of faltering growth in patients with univentricular heart is analyzed, focusing on the pathogenesis of malnutrition, its detection and evaluation. Secondly, we summarize the nutritional issues of each life phase of a Fontan patient from birth to adulthood. Finally, we highlight the challenges of nutritional management in patients with failing Fontan.

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From heart to gut: Exploring the gut microbiome in congenital heart disease

Liu,

Huang,

et al. 2023

iMeta

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Congenital heart disease (CHD) is a prevalent birth defect and a significant contributor to childhood mortality. The major characteristics of CHD include cardiovascular malformations and hemodynamical disorders. However, the impact of CHD extends beyond the circulatory system. Evidence has identified dysbiosis of the gut microbiome in patients with CHD. Chronic hypoxia and inflammation associated with CHD affect the gut microbiome, leading to alterations in its number, abundance, and composition. The gut microbiome, aside from providing essential nutrients, engages in direct interactions with the host immune system and indirect interactions via metabolites. The abnormal gut microbiome or its products can translocate into the bloodstream through an impaired gut barrier, leading to an inflammatory state. Metabolites of the gut microbiome, such as short‐chain fatty acids and trimethylamine N‐oxide, also play important roles in the development, treatment, and prognosis of CHD. This review discusses the role of the gut microbiome in immunity, gut barrier, neurodevelopment, and perioperative period in CHD. By fostering a better understanding of the cross‐talk between CHD and the gut microbiome, this review aims to contribute to improve clinical management and outcomes for CHD patients.

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Elevated serum levels of ghrelin and TNF-α in patients with cyanotic and acyanotic congenital heart disease

Abstract: Our meta-analysis results showed that serum levels of ghrelin and TNF-α are elevated in children with CHD, and could be used as effective biologic markers in early diagnosis of CHD.

Cited by 10 publications

References 33 publications

Body composition, appetite-related hormones, adipocytokines, and heart failure in adult patients with congenital heart disease: A preliminary study

Body composition, appetite-related hormones, adipocytokines, and heart failure in adult patients with congenital heart disease: A preliminary study

Nutritional Management of Patients with Fontan Circulation: A Potential for Improved Outcomes from Birth to Adulthood

From heart to gut: Exploring the gut microbiome in congenital heart disease

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