Elevated serum levels of thioredoxin in patients with acute exacerbation of asthma

Yamada, Yoshiyuki; Nakamura, Hajime; Adachi, Tomohiko; Sannohe, Satoshi; Oyamada, Hirokazu; Kayaba, Hiroyuki; Yodoi, Junji; Chihara, Junichi

doi:10.1016/s0165-2478(03)00006-3

Cited by 77 publications

(48 citation statements)

References 28 publications

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“…We demonstrate that TRX prevents histamine release from mast cells, which is an essential reaction of allergic diseases. We reported that serum TRX levels increased in patients with asthma, especially in the phase of asthma attack [32]. Oxidative stress and oxidants have been implicated in the pathogenesis of asthma, and increased release of ROS.…”

Section: Discussionmentioning

confidence: 88%

Redox regulation of mast cell histamine release in thioredoxin-1 (TRX) transgenic mice

et al. 2006

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Section: Discussionmentioning

confidence: 88%

Redox regulation of mast cell histamine release in thioredoxin-1 (TRX) transgenic mice

et al. 2006

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“…Several studies have demonstrated protective effect of TRX in diseases associated with increased oxidative stress such as post-ischaemic reperfusion injury, adriamycin-induced cardiotoxicity and diabetic nephropathy [18][19][20][21]. Additionally, while elevated serum levels of TRX are seen in patients with acute asthma exacerbations [22], the administration of exogenous TRX suppress AHR and airway inflammation in a murine model of asthma [23]. These results suggest that TRX may play a protective role in the Th2-driven airway inflammation; however, the mechanism by which TRX affects airway inflammation is unclear.…”

Section: Introductionmentioning

confidence: 99%

Thioredoxin suppresses airway inflammation independently of systemic Th1/Th2 immune modulation

Torii

Wang

et al. 2010

Eur J Immunol

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Oxidative stress plays an important role in the pathogenesis of asthma via the upregulation of local inflammatory mediators and/or promoting Th2-skewing during Ag sensitization. Thioredoxin (TRX), a 12 kDa redox-active protein with antioxidative property, has been recently shown to play a protective role in various inflammatory diseases. Using a mouse model of asthma, we show here that IL-13 and eotaxin production are decreased in TRX-Tg mice leading to reduced eosinophils recruitment and mucus metaplasia. The reduction in airway inflammation occurs without the attenuation of systemic Th2 immunity in that comparable levels of Th2-type cytokines and Ig were detected in LN and serum, respectively, from TRX-Tg and WT mice. Likewise, CD4 1 T cells from both strains of mice developed similar Th1 and Th2 responses in vitro. Asthmatic lungs of TRX-Tg and WT mice contained similar amounts of GATA-3 1 and Foxp3 1 T cells. Finally, production of MIF, an upstream modulator of airway inflammation, was significantly reduced in the lungs of TRX-Tg mice. Our data suggest that TRX suppresses airway inflammation by inhibiting MIF production thereby limiting the downstream recruitment of eosinophils to the lung independently of modulating systemic Th1/Th2 immunity.

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“…При БА, особенно во время обострения, на-блюдается высокий уровень экспрессии тиоредок-синов (thioredoxin -TRX) и пероксиредоксинов (peroxiredoxin -PRX), а гипероксидация последних коррелирует с тяжестью заболевания [14,27]. От-носительно высокий уровень TRX и PRX, по всей вероятности, играет протективную роль.…”

Section: резюме в обзоре литературы изложены современные данные о спunclassified

Нозоспецифічні Особливості Редокс-Процесів При Бронхіальній Астмі Та Хронічній Обструктивній Хворобі Легень

Babуch¹,

Волосовец²,

Borysovа³

2021

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В огляді літератури викладено сучасні дані щодо специфічних особливостей оксидантного стресу, функціональної активності антиоксидантної системи та розвитку запального процесу при бронхіальній астмі і хронічній обструктивній хворобі легень.

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Elevated serum levels of thioredoxin in patients with acute exacerbation of asthma

Cited by 77 publications

References 28 publications

Redox regulation of mast cell histamine release in thioredoxin-1 (TRX) transgenic mice

Redox regulation of mast cell histamine release in thioredoxin-1 (TRX) transgenic mice

Thioredoxin suppresses airway inflammation independently of systemic Th1/Th2 immune modulation

Нозоспецифічні Особливості Редокс-Процесів При Бронхіальній Астмі Та Хронічній Обструктивній Хворобі Легень

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