Elevated serum periostin levels among arsenic-exposed individuals and their associations with the features of asthma

Tony, S.; Haque, Nazmul; Siddique, Abu Eabrahim; Khatun, Moriom; Rahman, Mizanur; Islam, Zohurul; Islam, Md. Kamrul; Islam, Jahidul; Hossain, Sabbir; Hoque, Md. Ashraful; Saud, Zahangir Alam; Sumi, Daigo; Wahed, Abdus S.; Barchowsky, Aaron; Himeno, Seiichiro; Hossain, Khaled

doi:10.1016/j.chemosphere.2022.134277

Cited by 5 publications

(14 citation statements)

References 79 publications

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“…The authors also reported that type 2 cytokines increased with a higher concentration of arsenic in drinking water, hair, and nails [ 18 ]. Results in the same direction have been found with respect to serum periostin, which was positively associated with asthma symptoms and Th2 mediators [ 35 ].…”

Section: Discussionsupporting

confidence: 73%

“…Evidence regarding the effect of arsenic on the immune system provides an avenue to explain possible mechanisms of action on the development of childhood asthma. Several studies have shown that arsenic has an immunomodulatory effect on the synthesis of immunoglobulin E, Th2 cytokines (interleukins IL-4, IL-5, IL-13, and eotaxin), and periostin [ 17 , 18 , 35 , 36 , 37 ]. These mediators trigger the inflammatory reaction in airway cells, leading to the release of histamine, prostaglandins, and leukotrienes that produce asthma symptoms in children [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

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Urinary Arsenic Concentration and Its Relationship with Bronchial Asthma in Children from Arica, Chile

Muñoz

Iglesias

Saavedra

et al. 2022

Toxics

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In the city of Arica, northern Chile, the population has been involuntarily exposed to arsenic of natural and anthropogenic origin. This study aims to evaluate the association between urinary arsenic concentration and bronchial asthma diagnosis in the children of Arica. A cross-sectional analysis of a database of 1892 subjects under 18 years of age enrolled in the Environmental Health Centre between 2009 and 2021 was carried out. Arsenic exposure was obtained from a urine sample and bronchial asthma diagnosis from the database of the system for the management of explicit health guarantees. Logistic regression models were used to assess the association between inorganic arsenic and asthma. The median inorganic arsenic was 15 μg/L, and the prevalence of asthma was 7.4%. After adjusting for sex, age, ethnicity, and urinary creatinine, children with the highest tertile of urinary arsenic concentration (≥21.4 μg/L) had a greater chance of developing asthma (odds ratio (OR) 1.90; 95% confidence interval (CI) [1.13–3.18]). When exploring the modifying effect of ethnicity, the association increased among children belonging to any ethnic group (OR 3.51, 95%CI [1.43–8.65]). These findings suggest a relationship between arsenic exposure and bronchial asthma in children. While further studies are needed to assess the impact of arsenic on respiratory health, mitigation efforts to reduce arsenic exposure should be maintained.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Urinary Arsenic Concentration and Its Relationship with Bronchial Asthma in Children from Arica, Chile

Muñoz

Iglesias

Saavedra

et al. 2022

Toxics

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“…The participants were 18–60 years old and had lived in their areas for at least five years. Including the present one, we have conducted a couple of studies [ 45 , 47 ] using serum samples of the participants who were recruited in our previous study [ 46 ]. The overall response rate of the previous study [ 46 ] was 92% (93% from arsenic-endemic areas, and 91% from non-endemic area).…”

Section: Methodsmentioning

confidence: 99%

“…Arsenic concentrations in drinking water, hair, and nails of the participants were determined in our previous studies [ 45 , 46 ] using inductively coupled plasma mass spectroscopy (ICP-MS) (Agilent 7700x, Japan) with the detection limit of 3.33×10 −3 ppb. The accuracy of the measurement was validated using appropriate certified reference materials.…”

Section: Methodsmentioning

confidence: 99%

“…Although periostin is involved in various kinds of skin pathologies, the roles of periostin in arsenic-induced skin lesions remain unknown. Therefore, we explored the association between arsenic-induced skin lesions and serum periostin levels among the participants who were recruited in our previous study [ 45 ] from the low- and high-arsenic exposure areas in Bangladesh.…”

Section: Introductionmentioning

confidence: 99%

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Association between serum periostin levels and the severity of arsenic-induced skin lesions

et al. 2023

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Arsenic is a potent environmental toxicant and human carcinogen. Skin lesions are the most common manifestations of chronic exposure to arsenic. Advanced-stage skin lesions, particularly hyperkeratosis have been recognized as precancerous diseases. However, the underlying mechanism of arsenic-induced skin lesions remains unknown. Periostin, a matricellular protein, is implicated in the pathogenesis of many forms of skin lesions. The objective of this study was to examine whether periostin is associated with arsenic-induced skin lesions. A total of 442 individuals from low- (n = 123) and high-arsenic exposure areas (n = 319) in rural Bangladesh were evaluated for the presence of arsenic-induced skin lesions (Yes/No). Participants with skin lesions were further categorized into two groups: early-stage skin lesions (melanosis and keratosis) and advanced-stage skin lesions (hyperkeratosis). Drinking water, hair, and nail arsenic concentrations were considered as the participants’ exposure levels. The higher levels of arsenic and serum periostin were significantly associated with skin lesions. Causal mediation analysis revealed the significant effect of arsenic on skin lesions through the mediator, periostin, suggesting that periostin contributes to the development of skin lesions. When skin lesion was used as a three-category outcome (none, early-stage, and advanced-stage skin lesions), higher serum periostin levels were significantly associated with both early-stage and advanced-stage skin lesions. Median (IQR) periostin levels were progressively increased with the increasing severity of skin lesions. Furthermore, there were general trends in increasing serum type 2 cytokines (IL-4, IL-5, IL-13, and eotaxin) and immunoglobulin E (IgE) levels with the progression of the disease. The median (IQR) of IL-4, IL-5, IL-13, eotaxin, and IgE levels were significantly higher in the early-and advanced-stage skin lesions compared to the group of participants without skin lesions. The results of this study suggest that periostin is implicated in the pathogenesis and progression of arsenic-induced skin lesions through the dysregulation of type 2 immune response.

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Effect of Arsenic Exposure on AS3MT Protein Levels in Serum of Type 2 Diabetic Patients Compared to Non-diabetics

Shokat,

Iqbal,

Ali

et al. 2024

Biol Trace Elem Res

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Elevated serum periostin levels among arsenic-exposed individuals and their associations with the features of asthma

Cited by 5 publications

References 79 publications

Urinary Arsenic Concentration and Its Relationship with Bronchial Asthma in Children from Arica, Chile

Urinary Arsenic Concentration and Its Relationship with Bronchial Asthma in Children from Arica, Chile

Association between serum periostin levels and the severity of arsenic-induced skin lesions

Effect of Arsenic Exposure on AS3MT Protein Levels in Serum of Type 2 Diabetic Patients Compared to Non-diabetics

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