Elevated serum progesterone levels on the day of human chorionic gonadotropin administration in in vitro fertilization cycles do not adversely affect embryo quality

Silverberg, Kaylen M.; Martin, Maxine B; Olive, David L.; Burns, William N.; Schenken, Robert S.

doi:10.1016/s0015-0282(16)56584-4

Cited by 81 publications

(65 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been observed, in frozen embryo transfer (Silverberg et al, 1994) as well as in ovum donation (Righini et al, 1994) cycles, that early increases in progesterone did not have the above-mentioned deleterious effect on pregnancy rates encountered in autologous ovarian stimulation. This also points to a possible controlling factor operating between progesterone (i.e.…”

Section: Discussionmentioning

confidence: 96%

Implantation: Endometrial and placental protein markers and ovarian steroids in serum during in-vitro fertilization cycles

1995

View full text Add to dashboard Cite

The objective of this study was to find the earliest time at which it was possible to detect clinical pregnancy in an invitro fertilization (IVF) treatment cycle supported with human chorionic gonadotrophin (HCG), and also retrospectively to diagnose abnormal ovarian-or endometriumrelated situations in failure cycles. Serum samples were taken in 41 IVF cycles at frequent intervals from the beginning of ovarian stimulation until menstrual bleeding occurred or a pregnancy was established. Concentrations of oestradiol, progesterone, placental protein 14 (PP14), pregnancy-specific pi-glycoprotein (SPj), and pregnancyassociated plasma protein A (PAPP-A) were determined in the serum samples using commercially available (steroid) or purpose-developed (protein) immunoassays. The cycles were retrospectively distributed into four outcome groups: (i) fertilization failure (FF, n = 8); (ii) implantation failure (IF, n = 10); (iii) 'interaction' (embryo-endometrium) cycle (IC, n = 14), and (iv) clinical pregnancy (CP, n = 9). The embryo-endometrium interaction was detected by a rise in SP! in 23 cycles (70% of embryo transfers) at a time when endogenous HCG was still masked by external support. Early ('false') positive SP] concentrations were observed in two out of eight and five out of 14 cases in groups FF and IC respectively, but never amongst the ongoing pregnancies (CP). PAPP-A did not distinguish pregnancy from the other outcomes. The PP14/progesterone ratio was lower, later in the cycle, in CP than in the other groups. We conclude that, while it is not possible to predict the outcome of a given IVF cycle earlier than 2 weeks after embryo transfer, the hormonal patterns can be used to detect abnormalities (e.g. endometrial asynchrony) which may be useful for subsequent treatment cycles in the same patient.

show abstract

Section: Discussionmentioning

confidence: 96%

Implantation: Endometrial and placental protein markers and ovarian steroids in serum during in-vitro fertilization cycles

1995

View full text Add to dashboard Cite

show abstract

“…Indeed, Silverberg et aL have reported no demonstrable adverse affect in quality of oocytes or embryos among patients with elevated P4 on the day of hCG (19). Comparing the success of frozen ETs between high-and low-P4 patients, the authors reported equal pregnancy rates and were unable to attribute the poor pregnancy rates observed during the initial IVG/ET high-P4 cycles to hormonal action on the oocyte (19). The quality of oocytes recov-ered during our study was comparable to that of oocytes recovered during our simultaneously running IVF-ET program.…”

Section: Discussionmentioning

confidence: 98%

“…Edwards observed an increase in dispermic and fragmented embryos coincident with high levels of progesterone (17), though others have not supported this finding (18). Indeed, Silverberg et aL have reported no demonstrable adverse affect in quality of oocytes or embryos among patients with elevated P4 on the day of hCG (19). Comparing the success of frozen ETs between high-and low-P4 patients, the authors reported equal pregnancy rates and were unable to attribute the poor pregnancy rates observed during the initial IVG/ET high-P4 cycles to hormonal action on the oocyte (19).…”

Section: Discussionmentioning

confidence: 99%

Direct gamete uterine transfer in patients with tubal absence or occlusion

Ransom

Garcia

Doherty

et al. 1997

J Assist Reprod Genet

View full text Add to dashboard Cite

“…In these articles, 0.9 ng/ml was found as the lowest threshold for P concentration and 1.5 ng/ml was found as the highest threshold. Although different cut-offs have been used over the years ranging from 0.8 to even 2 ng/ml (Hofmann et al, 1993;Ubaldi et al, 1996;Silverberg et al, 1994;Edelstein et al, 1990;Givens et al, 1994), in recent publications the upper cut-off level is set at 1.5 ng/ml.…”

Section: Patient Groupsmentioning

confidence: 99%