Elevated serum S-100B levels in children with temporal lobe epilepsy

Çalık, Mustafa; Abuhandan, Mahmut; Sönmezler, Abdurrahman; Kandemır, Hasan; Öz, İbrahim İlker; Taşkın, Abdullah; Selek, Sahabettın; İşcan, Akın

doi:10.1016/j.seizure.2012.10.012

Cited by 39 publications

(32 citation statements)

References 16 publications

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“…For example, high levels of S100B in the serum of the cerebrospinal fluid have been reported for schizophrenia [17,18] , major depression [19] , traumatic brain damage [20,21] , brain ischemia [22,23] , neurodegenerative disease [24,25] , and during acute episodes of bipolar disorder [26] . In addition, Calik et al [27] showed elevated S100B levels in patients with different kinds of epilepsy, and it was suggested that an increased serum concentration of S100B might be indicative of neuronal damage.…”

Section: Discussionmentioning

confidence: 99%

Increased S100B Levels in Cannabis Use Disorder

et al. 2015

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Background: It has been determined that cannabis has adverse effects on brain tissue, and that increased S100 calcium binding protein B (S100B) blood levels are markers of neuronal damage. Therefore, the aim of this study was to evaluate the S100B levels in cannabis use disorder. Method: Thirty-two patients with cannabis use disorder and 31 matched healthy controls were enrolled in this study. Appropriate blood samples were taken from the enrolled subjects, and the serum S100B protein levels were measured with an electrochemiluminescence immunoassay for the quantification of the protein. Findings: We found significantly increased S100B protein levels in patients with cannabis use disorder. The mean serum concentration of S100B was 0.081 ± 0.018 μg/l in patients with cannabis use disorder, and 0.069 ± 0.018 μg/l in the control group (p = 0.008). Interpretation: Our data suggest that elevated S100B protein levels might indicate neuronal damage in the brains of people with cannabis use disorder.

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Section: Discussionmentioning

confidence: 99%

Increased S100B Levels in Cannabis Use Disorder

et al. 2015

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“…S100 combines with receptors for advanced glycation end-product (RAGE) in the extracellular matrix and plays a critical role in the glial modulation of neuronal synaptic plasticity 6 . The serum levels of S100-B are increased in children with temporal lobe epilepsy 7 . High RAGE expression is observed in inflammatory lesions, and the blocking of RAGE delays the development of an inflammatory response 8 .…”

Section: Introductionmentioning

confidence: 94%

Long-term electrical stimulation at ear and electro-acupuncture at ST36-ST37 attenuated COX-2 in the CA1 of hippocampus in kainic acid-induced epileptic seizure rats

Liao

Tang

Lin

et al. 2017

Sci Rep

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Seizures produce brain inflammation, which in turn enhances neuronal excitability. Therefore, anti-inflammation has become a therapeutic strategy for antiepileptic treatment. Cycloxygenase-2 (COX-2) plays a critical role in postseizure brain inflammation and neuronal hyperexcitability. Our previous studies have shown that both electrical stimulation (ES) at the ear and electro-acupuncture (EA) at the Zusanli and Shangjuxu acupoints (ST36–ST37) for 6 weeks can reduce mossy fiber sprouting, spike population, and high-frequency hippocampal oscillations in kainic acid (KA)-induced epileptic seizure rats. This study further investigated the effect of long-term ear ES and EA at ST36–ST37 on the inflammatory response in KA-induced epileptic seizure rats. Both the COX-2 levels in the hippocampus and the number of COX-2 immunoreactive cells in the hippocampal CA1 region were increased after KA-induced epileptic seizures, and these were reduced through the 6-week application of ear ES or EA at ST36–ST37. Thus, long-term ear ES or long-term EA at ST36–ST37 have an anti-inflammatory effect, suggesting that they are beneficial for the treatment of epileptic seizures.

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“…3,15 S-100B protein levels have been suggested to be reflective of certain pathological conditions in the brain and/or bloodbrain barrier, may correlate with the overall degree of damage and be of value in predicting the extent of the damage. 16 Studies have reported elevated serum and CSF S-100B levels in patients with traumatic brain damage, 17,18 stroke, 19 subarachnoid hemorrhage, 20 schizophrenia, 21 and bacterial meningitis, [22][23][24] premature babies with hypoxic-ischemic encephalopathy and intraventricular hemorrhage, 25 and patients with temporal lobe epilepsy 26,27 compared with control subjects. Portela et al 28 reported normal S-100B protein levels in patients with focal epilepsy.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Serum S-100B Protein Levels in Patients with Simple Febrile Convulsions

et al. 2016

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Objective?This study aimed at evaluating serum S-100B protein levels after convulsions in children experiencing simple febrile convulsions. Material and Methods?The study included 30 healthy children as the control group and 30 patients with simple febrile convulsions as the study group. Blood samples were obtained within 2 hours after the patients sustained febrile convulsions. Serum S-100B protein levels of the patients in the study group and the control group were measured using enzyme-linked immunosorbent assay kits. Results?There was no statistically significant difference between the groups, when the mean serum S-100B protein levels were compared between patients with febrile convulsions and the control group (p?>?0.05). Conclusion?Lack of an increase in serum S-100B protein levels of patients with simple febrile convulsion suggests that febrile convulsive seizures do not cause any organ damage.

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Elevated serum S-100B levels in children with temporal lobe epilepsy

Abstract: Our data suggest that increased S-100B protein levels in the serum might reflect neuronal damage in the brains of children with temporal lobe epilepsy. These results do confirm the previous findings of elevated S-100B protein levels in adult patients with temporal lobe epilepsy.

Cited by 39 publications

References 16 publications

Increased S100B Levels in Cannabis Use Disorder

Increased S100B Levels in Cannabis Use Disorder

Long-term electrical stimulation at ear and electro-acupuncture at ST36-ST37 attenuated COX-2 in the CA1 of hippocampus in kainic acid-induced epileptic seizure rats

Evaluation of Serum S-100B Protein Levels in Patients with Simple Febrile Convulsions

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