Elevated serum tartrate-resistant acid phosphatase isoform 5a levels in metabolic syndrome

Abstract

BackgroundTartrate-resistant phosphatase isoform 5a is expressed in tumor-associated macrophages and is a biomarker of chronic inflammation. Herein, we correlated serum tartrate-resistant phosphatase isoform 5a levels with metabolic syndrome status and made comparisons with traditional markers of inflammation, including c-reactive protein and interleukin-6.MethodsOne hundred healthy volunteers were randomly selected, and cut-off points for metabolic syndrome related inflammatory biomarkers were determined using receiver operating characteristic curves. Linear and logistic regression models were subsequently used to correlate inflammatory markers with the risk of metabolic syndrome.ResultsTwenty-two participants met the criteria for metabolic syndrome, and serum tartrate-resistant phosphatase isoform 5a levels of >5.8 μg/L were associated with metabolic syndrome (c-statistics, 0.730; p = 0.001; 95% confidence interval, 0.618–0.842). In addition, 1 μg/L increases in tartrate-resistant phosphatase isoform 5a levels were indicative of a 1.860 fold increase in the risk of metabolic syndrome (p = 0.012).ConclusionsElevated serum tartrate-resistant phosphatase isoform 5a levels are associated with the risk of metabolic syndrome, with a cut-off level of 5.8 μg/L.

Intensive weight gain therapy in patients with anorexia nervosa results in improved serum tartrate-resistant acid phosphatase (TRAP) 5a and 5b isoform protein levels

“…The observed delta values in serum TRAP 5a, between baseline and 12 weeks and TRAP 5a/5b ratio at week 1, were correlated to changes in serum insulin indicating that TRAP 5a is involved in metabolic changes, which is in conjunction with previous reports [33,36]. However, the exact mechanism by which TRAP 5a responds to metabolic changes and insulin sensitivity/resistance remains to be elucidated.…”

“…The TRAP 5a/TRAP 5b ratio was also significantly altered with approximately a 4-fold increase). The abundance of TRAP 5a, that is, 4-fold more than TRAP 5b, has previously been reported in healthy individuals where TRAP 5a has been in the range of 4-8 ng/ml [33,34], while other studies have reported TRAP 5b levels in the range of 1-3 ng/ml [23,24]. Thus far, there are no studies that have investigated the ratio between TRAP 5a and 5b directly in the same serum sample from humans.…”