Elevated serum uric acid and triglycerides level in the patients with Type II Diabetes Mellitus- a Nepalese case control study

Parajuli, Hridaya; Shakya, Jyotsna; Pardhe, Bashu Dev; Khanal, Puspa Raj; Parajuli, Narayan Prasad; Maharjan, Pooja; Joshi, Govardhan; Hamza, Alneil; Pandeya, Dipendra Raj

doi:10.3126/acclm.v2i2.15590

Cited by 3 publications

(3 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…52 Similar findings have been reported by different previous studies from Nepal. [53][54][55] This also highlights the need of interventions for prevention and control of several of these metabolic risk factors such as dyslipidaemia so as to achieve DM control in Nepal.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of diabetes mellitus and associated risk factors in Nepal: findings from a nationwide population-based survey

et al. 2022

View full text Add to dashboard Cite

ObjectivesThe burden of diabetes mellitus (DM) has increased globally, particularly in low-income and middle-income countries, including Nepal. Population-based nationally representative data on the prevalence of DM is limited. This paper presents the prevalence of DM and its associated risk factors in Nepal.Research designs and methodsThis population-based study sampled 13 200 participants aged 20 years and above in 400 clusters of 72 districts of Nepal. The study used a standardised questionnaire adapted from the WHO STEPwise approach to non-communicable disease risk factor surveillance instrument and digitalised in Android-compatible mobile phones. Fasting and 2 hours postprandial blood samples were taken to test various biochemical parameters. Descriptive followed by multivariate analyses were done to assess the association between explanatory variables and the outcome variable.Primary outcome measuresPrevalence of DM.ResultsThe prevalence of DM was found to be 8.5% (95% CI 7.8% to 9.3%). The odds of DM occurrence were higher in the upper age groups (40–59 years at adjusted OR (AOR) 3.1 (95% CI2.3 to 4.2) and 60+ years at AOR 4.7 (95% CI 3.3 to 6.6)), compared with the group aged 20–39 years. Men were found to have higher odds of DM (AOR 1.3, 95% CI 1.1 to 1.6) compared with women. Urban residents had almost twice higher odds of DM (AOR 1.7, 95% CI 1.4 to 2.2) compared with rural residents. Participants with raised blood pressure (BP) (AOR 2.2, 95% CI 1.8 to 2.7), those who were overweight and obese (AOR 2.0, 95% CI 1.6 to 2.4) and those who had high triglycride level (≥150 mg/dL) (AOR 2.1, 95% CI 1.8 to 2.6) also had twice higher odds of DM compared with those with normal BP, an average body mass index and normal triglyceride level, respectively.ConclusionsTargeted interventions to higher risk groups as well as prevention and control of other associated biological risk factors might help to reduce the prevalence of DM in Nepal.

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence of diabetes mellitus and associated risk factors in Nepal: findings from a nationwide population-based survey

et al. 2022

View full text Add to dashboard Cite

show abstract

“…In another study conducted in Nepal reported the prevalence rate to be 28%. 21 Similarly a study conducted in Nigeria reported the prevalence rate to be 25%. Likewise, hyperuricemia in DM is also shown by other various studies.…”

Section: Discussionmentioning

confidence: 97%

Evaluation of Serum Uric Acid, Glucose and Other Glycemic Parameter in Type Ii Diabetic Individuals

Dhungana

Pandeya

Pant

et al. 2022

JCMC

View full text Add to dashboard Cite

Background: In spite of antioxidant property serum uric acid (SUA) has a positive association with blood glucose. SUA is considered as a strong and an independent risk factor for diabetes but low serum level of uric acid has been reported in the hyperglycemic state. Diabetes mellitus is a metabolic disorder of multiple etiologies resulting from defect in insulin action. So, aim of this study is to assess whether there is any change in SUA level and to establish whether there is any association with type II diabetes mellitus (DM) or not. Methods: A cross sectional study was conducted in 264 cases of DM. SUA, fasting blood glucose (FBG), post-prandial blood glucose (PPBG) and glycated hemoglobin (HbA1c) level were measured. Pearson’s correlation was employed to calculate the ‘r’ value by using SPSS version 15. Results: In our study prevalence of hyperuricemia was 18.5%. Mean SUA in male and female was 5.95 mg/dl and 5.54 mg/dl respectively in DM. HbA1c has positive correlation with FBG and PPBG (r value = 0.720 and 0.775, respectively p=<0.001), while SUA has negative correlation with HbA1c, FBG and PPBG (r value= -0.179, p =0.004, -0.070, p=0.257 and -0.078, p=-0.204 respectively.). Conclusions: SUA level is increased in DM. SUA was high among male and SUA initially increased when FBS and HbA1c increases then decreases as FBG and HbA1c level were further increased. SUA has negative correlation with FBG, PPBG and HbA1c, while HbA1c has a positive correlation with FBG and PPBG.

show abstract

“…8,9 A study from Nepal stated SUA was higher in patients with diabetes than in without diabetes. 10 Since the association of UA in patients without diabetes and with diabetes is not consistent, studies are required to know the actual trend of SUA in healthy and diabetic individuals. Although, there are some studies on the relationship between SUA and diabetes from different parts of the world, there are very few studies in Nepal.…”

Section: Introductionmentioning

confidence: 99%

Association between Serum Uric Acid and Blood Glucose Level in Diabetic and Non-diabetic Patients

et al. 2022

View full text Add to dashboard Cite

Uric acid increases insulin resistance; likewise, hyperinsulinemia increases uric acid concentration, and both are global health problems. This study is conducted to find the association between serum uric acid and blood glucose level. This was a cross-sectional study conducted in the Department of Biochemistry and Internal Medicine at Dhulikhel Hospital, Nepal, for a duration of six months (September 2021 - February 2022). A total of 130 diabetic patients who consented were compared with 130 non-diabetics by using non-probability convenient sampling technique. Ethical clearance was taken from the Institutional Review Committee-Kathmandu University School of Medical Sciences. Venous blood was collected and fasting blood glucose, post-prandial blood glucose, and serum uric acid were measured. Data were analyzed in the Statistical Package for Social version 16.0. Analytical data were compared using Mann Whitney U test, and Spearman correlation was performed to correlate numerical parameters. Statistical significance was defined as a two-sided p-value of less than 0.05. The median of serum uric acid level was significantly higher in diabetics than non-diabetics; the level of fasting and post-prandial blood glucose positively correlated with serum uric acid (p<0.05). Hyperuricemia was more in diabetics than non-diabetics (p<0.05). Serum uric acid level increased with the increase in age and duration of diabetes.

show abstract

Elevated serum uric acid and triglycerides level in the patients with Type II Diabetes Mellitus- a Nepalese case control study

Abstract: BACKGROUND

Cited by 3 publications

References 14 publications

Prevalence of diabetes mellitus and associated risk factors in Nepal: findings from a nationwide population-based survey

Prevalence of diabetes mellitus and associated risk factors in Nepal: findings from a nationwide population-based survey

Evaluation of Serum Uric Acid, Glucose and Other Glycemic Parameter in Type Ii Diabetic Individuals

Association between Serum Uric Acid and Blood Glucose Level in Diabetic and Non-diabetic Patients

Contact Info

Product

Resources

About