Elevated serum vitellogenin levels and gonadal abnormalities in wild male flounder (Pleuronectes yokohamae) from Tokyo Bay, Japan

Hashimoto, Shinichi; Bessho, Hiroki; Hara, Akihiko; Nakamura, Masaru; Iguchi, Taisen; Fujita, Kiyoshi

doi:10.1016/s0141-1136(99)00047-1

Cited by 190 publications

(131 citation statements)

References 29 publications

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“…However, although reproductive success may be impaired as a result of these changes, implications for these fish populations are still unclear (EDMAR, 2002). Similar effects to those described in flounder from the UK have also been observed in Japanese flounder Pleuronectes yokohamae from Tokyo Bay (Hashimoto et al, 2000). The causative substances have not yet been fully identified, but as with freshwaters, mixtures of potentially oestrogenic substances have been detected in estuarine waters.…”

Section: Fishsupporting

confidence: 69%

Partitioning, bioavailability and effects of oestrogens and xeno-oestrogens in the aquatic environment

et al. 2005

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This review provides insights into the distribution and impact of oestrogens and xenooestrogens in the aquatic environment and highlights some significant knowledge gaps in our understanding of endocrine disrupting chemicals. Key areas of uncertainty in the assessment of risk include the role of estuarine sediments in mediating the fate and bioavailability of environmental (xeno)oestrogens (notably their transfer to benthic organisms and estuarine food chains), together with evidence for endocrine disruption in invertebrate populations.Emphasis is placed on using published information to interpret the behaviour and effects of a small number of 'model compounds' thought to contribute to oestrogenic effects in nature; namely, the natural steroid 17β-estradiol (E2) and the synthetic hormone 17α-ethinylestradiol (EE2), together with the alkylphenols octyl-and nonylphenol (OP, NP) as oestrogen mimics. Individual sections of the review are devoted to sources and concentrations of (xeno)oestrogens in waterways, sediment partitioning and persistence, bioaccumulation rates and routes, assays and biomarkers of oestrogenicity, and, finally, a synopsis of reproductive and ecological effects in aquatic species.

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Section: Fishsupporting

confidence: 69%

Partitioning, bioavailability and effects of oestrogens and xeno-oestrogens in the aquatic environment

et al. 2005

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“…Additionally, the highest values of VTG, which is the complete type of VTG (Vg-530), were 6.035 and 2.780 g/ml in Japanese common goby from Osaka and Tokyo Bay, respectively, (Ohkubo et al, 2003b) and 2.2 g/ml in the flounder from Tokyo Bay (Hashimoto et al, 2000). These sites are in an industrial metropolitan area, and it is believed that VTG production is induced by the effluent of industrial and domestic waste.…”

Section: Discussionmentioning

confidence: 98%

“…Therefore, it is likely that the testis-ova found in our study were attributed to EEs. The flounder and the konoshiro gizzard shad in Tokyo Bay and the grey mullet in Tokyo, Osaka, and Fukuoka also had testis-ova , Hashimoto et al, 2000, Hashimoto et al, 2001. Moreover, the flounder collected in the UK had also testis-ova (Allen et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…However, there are few examples of field surveys in coastal areas using these biomarkers for EEs exposure. For example, in a previous study, testis-ova was observed in male flounders and male konoshiro gizzard shads (Konosirus punctatus) in Tokyo bay (Hashimoto et al, 2000, Hashimoto et al, 2001) and suggested exposure to EEs.…”

Section: Introductionmentioning

confidence: 93%

“…In Japanese estuarine and coastal areas, the male flounder (Pleuronectes yokohamae) (Hashimoto et al, 2000) and the male common goby (Acanthogobius flavimanus) (Ohkubo et al, 2003b) showed high levels of VTG in their serum. In estuarine areas of the UK, the male flounder (Platichthys flesus) has been also found with elevated concentrations of VTG in their serum (Allen et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

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Survey of contamination of estrogenic chemicals in Japanese and Korean coastal waters using the wild grey mullet (Mugil cephalus)

Aoki

Nagae

Takao

et al. 2010

Science of The Total Environment

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We monitored the contamination by environmental estrogens (EEs) of coastal areas in Korea and Japan using the wild grey mullet. The grey mullet were collected from Ansan, Jeju, Yeosu, Tongyeong, and Busan in Korea and Nagasaki, Omuta, and Fukuoka in Japan.Contamination by EEs was determined by measuring vitellogenin (VTG) levels in serum and identifying gonadal abnormalities histologically (i.e., testis-ova). In four sites in Korea (Ansan, Yeosu, Tongyeong, and Busan) and two sites in Japan (Nagasaki and Fukuoka), serum VTG in immature and male grey mullet was detected at levels greater than 1.0 g/ml, which is considered to be an abnormal level. Although, testis-ova were observed in some individuals collected in Ansan, Tongyeong, and Busan in Korea and Omuta in Japan, there was no correlation between individuals with testis-ova and individuals with abnormal levels of VTG. Furthermore, in Japan, serum VTG levels of fish collected from Nagasaki and Fukuoka was also greater than 1.0 g/ml. Although individuals with testis-ova were found in Omuta, these fish expressed normal levels of serum VTG. Our results suggest that the grey mullet living in these coastal areas are influenced by EEs in the environment. Furthermore, it appears that the production of VTG and the occurrence of testis-ova are caused by different mechanisms.

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Endocrine‐Disrupting Compounds

Dietrich

Krieger

2008

Histological Analysis of Endocrine Disruptive Effects in Small Laboratory Fish

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Elevated serum vitellogenin levels and gonadal abnormalities in wild male flounder (Pleuronectes yokohamae) from Tokyo Bay, Japan

Cited by 190 publications

References 29 publications

Partitioning, bioavailability and effects of oestrogens and xeno-oestrogens in the aquatic environment

Partitioning, bioavailability and effects of oestrogens and xeno-oestrogens in the aquatic environment

Survey of contamination of estrogenic chemicals in Japanese and Korean coastal waters using the wild grey mullet (Mugil cephalus)

Endocrine‐Disrupting Compounds

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