Elevated Surfactant Protein A in Bronchoalveolar Lavage Fluids From Sarcoidosis and Hypersensitivity Pneumonitis Patients

Hamm, H; Lührs, Jörg; Rotaeche, Josune Guzman y; Costabel, Ulrich; Fabel, H; Bartsch, W.

doi:10.1378/chest.106.6.1766

Cited by 68 publications

(56 citation statements)

References 18 publications

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“…This is in concordance with studies in adults where a wide range of concentrations has been observed in healthy subjects, although significant difference have been observed between healthy individuals and patients with pulmonary disease [32][33][34]. We have observed a weak correlation between SP-A and the total phospholipid content for the group as a whole; however, the r-value of 0.46 would imply that only 20% of the variability is explained by the variation in phospholipid concentrations.…”

Section: +2 Sdsupporting

confidence: 91%

Age-dependency of surfactant phospholipids and surfactant protein A in bronchoalveolar lavage fluid of children without bronchopulmonary disease

Ratjen

Rehn²,

Costabel³

et al. 1996

Eur Respir J

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Whilst alterations in surfactant components of bronchoalveolar lavage fluid (BALF) have been described in a variety of pulmonary diseases in adults, no information is available on the surfactant composition in children beyond the neonatal period. In order to obtain reference values for the paediatric age group, we have studied phospholipid profiles of BALF in children without pulmonary disease.The study population consisted of 38 children aged 3-15 yrs (mean±SD 8±4 yrs) undergoing elective surgery for nonpulmonary illnesses. Surfactant composition was analysed by high pressure liquid chromatography using both an ultraviolet and a light-scattering detector.Total phospholipid concentration was higher in children under 8 yrs of age and decreased with age. In contrast, the total protein concentration remained constant throughout the age range. No age-related changes in the relative composition of phospholipid fractions could be observed. Surfactant protein A concentrations were highly variable in all age groups.This study provides the first data on surfactant components in bronchoalveolar lavage fluid of healthy children and will be the basis for future studies of children with pulmonary diseases.

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Section: +2 Sdsupporting

confidence: 91%

Age-dependency of surfactant phospholipids and surfactant protein A in bronchoalveolar lavage fluid of children without bronchopulmonary disease

Ratjen

Rehn²,

Costabel³

et al. 1996

Eur Respir J

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“…Inconsistent results also have been reported with regard to the effects of smoking on levels of SP-A in lavage fluids, which were decreased [15], slightly increased [16], or unchanged [17]. However, no changes were observed in rats exposed to cigarette smoke [18].…”

Section: Discussionmentioning

confidence: 74%

Effects of ageing and smoking on SP-A and SP-D levels in bronchoalveolar lavage fluid

et al. 2004

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Surfactant protein (SP)-A and SP-D are collagen-like glycoproteins that are synthesised in the distal pulmonary epithelium. This study examined the effects of ageing and long-term smoking on SP-A and SP-D in the lungs. The possible links to the development of pulmonary emphysema were also investigated.Sequential lavage was performed in young and middle-aged or elderly nonsmokers and asymptomatic current smokers with various smoking histories. Middle-aged or elderly smokers were further categorised according to the presence of emphysema by high-resolution computed tomography. Levels of SP-A and SP-D in bronchial lavage (BL) fluid and in bronchoalveolar lavage (BAL) fluid were quantified by ELISA.Significant decreases in SP-A were seen with age in nonsmokers in BL fluid, but not in BAL fluid. Middle-aged or elderly smokers with emphysema had lower levels of SP-A in both BL and BAL fluids when compared with young subjects, and in BL fluid when compared with middle-aged or elderly smokers without emphysema. SP-D did not change with age alone, however, it was decreased in middle-aged or elderly smokers when compared with similarly aged nonsmokers.In conclusion, surfactant protein-A may decrease with age alone or due to the cumulative effects of long-term smoking and development of emphysema, while surfactant protein-D decreases due to long-term smoking. Eur Respir J 2004; 24: 964-970.

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“…Reduced or unchanged SP-A and SP-D levels in BALF from clinically stable patients with cystic fibrosis have also been reported, but increased levels have been found when the disease progressed as a result of infection (30,31). SP-A or SP-D levels in BALF of pulmonary sarcoidosis patients have been reported to be increased (7,32), unchanged (7), or reduced (27,29). Increased SP-A or SP-D levels in BALF of pneumocystis carinii pneumonia (33) and pulmonary alveolar proteinosis (PAP) (29) have been reported.…”

Section: Discussionmentioning

confidence: 99%

KL-6 and Surfactant Proteins A and D in Serum and Bronchoalveolar Lavage Fluid in Patients with Acute Eosinophilic Pneumonia

et al. 2005

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Elevated Surfactant Protein A in Bronchoalveolar Lavage Fluids From Sarcoidosis and Hypersensitivity Pneumonitis Patients

Cited by 68 publications

References 18 publications

Age-dependency of surfactant phospholipids and surfactant protein A in bronchoalveolar lavage fluid of children without bronchopulmonary disease

Age-dependency of surfactant phospholipids and surfactant protein A in bronchoalveolar lavage fluid of children without bronchopulmonary disease

Effects of ageing and smoking on SP-A and SP-D levels in bronchoalveolar lavage fluid

KL-6 and Surfactant Proteins A and D in Serum and Bronchoalveolar Lavage Fluid in Patients with Acute Eosinophilic Pneumonia

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