Elevated Systemic and Parasite—Antigen Stimulated Levels of Type III IFNs in a Chronic Helminth Infection and Reversal Following Anthelmintic Treatment

Ray, Anuradha; Munisankar, Saravanan; Bhootra, Yukthi; Dolla, Chandrakumar; Nutman, Thomas B.; Babu, Subash

doi:10.3389/fimmu.2018.02353

Cited by 4 publications

(6 citation statements)

References 32 publications

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“…The results of our study are similar to other related studies, but there are also some differences: some studies have shown that the protective effect of helminth infection is transient and can be reversed by anthelmintic treatment 28,29 . The possible reason is that they researched soil‐transmitted helminths (STHs) infections, but we researched Schistosomiasis japonica infections.…”

Section: Discussionsupporting

confidence: 83%

“…Other evidence suggests that soil‐transmitted helminth (STH) infections are associated with lower insulin resistance (IR), but deworming programmes might remove this helminth‐associated protective effect 28 . Strongyloides stercoralis (Ss) infection is directly associated with increased parasite antigen stimulated levels of type III IFNs since anthelmintic treatment and presumed cure result in a significant reversal in the systemic levels of type III IFNs 29 …”

Section: Discussionmentioning

confidence: 99%

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Association of previous schistosome infection with fatty liver and coronary heart disease: A cross‐sectional study in china

Zou

Liu

Zhong

et al. 2021

Parasite Immunology

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Background More than 11 million people were estimated to have been infected by Schistosoma japonicum in China before the 1950s. However, few studies have been conducted to evaluate the longitudinal effects of previous schistosome infection (PSI). Objective We aimed to evaluate the association of PSI with fatty liver and coronary heart disease in China. Methods A cross‐sectional study was conducted in regions which were all reportedly heavily endemic for S japonicum in China. All data were collected using a questionnaire administered and health examinations by well‐trained medical professionals. 2867 participants aged 40 years and older were enrolled. Among these, 731 patients with PSI were selected as study subjects and 2136 subjects served as controls. Comparisons between groups were performed with or without an adjustment for a covariate, using Student's t tests for continuous variables and chi‐square testing for categorical variables. Multivariable logistic models were used to estimate the associations between PSI and fatty liver or coronary heart disease. Results The PSI participants had significantly lower levels of triglyceride, low‐density lipoprotein cholesterol, fasting blood glucose, uric acid, serum creatinine, urea nitrogen, platelet, total protein and globulin as well as a lower prevalence of fatty liver (13.3% vs 53.6%, P < .001) and coronary heart disease (3.4% vs 6.0%, P < .05) compared with the uninfected, contemporaneous controls (without PSI), whereas the PSI participants had higher levels of high‐density lipoprotein cholesterol, direct bilirubin and a higher prevalence of hepatic dysfunction compared with those without PSI (P < .05). Conclusion We found PSI significantly negatively associated with fatty liver and coronary heart disease. However, further studies on schistosomiasis may provide new directions for prevention and treatment of fatty liver and coronary heart disease.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Association of previous schistosome infection with fatty liver and coronary heart disease: A cross‐sectional study in china

Zou

Liu

Zhong

et al. 2021

Parasite Immunology

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“…We wanted to examine the Type1 and Type III IFN kinetics following RT-PCR confirmation from days 15-30 to more than 180 days. To this end, we combined all the groups irrespective of their disease status (mild, moderate, severe and convalescence) [12][13][14][15].…”

Section: Study Population Characteristicsmentioning

confidence: 99%

“…Acute COVID-19 (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) 151-180, n = 37 and more than 180, n = 40), residing in Chennai and Tiruvallur were enrolled in the study between November 2020 and December 2020 after taking informed consent from the study individuals. This was a cross-sectional study and different individuals were enrolled in the different categories.…”

Section: Study Populationmentioning

confidence: 99%

Restoration of dendritic cell homeostasis and Type I/Type III interferon levels in convalescent COVID-19 individuals

et al. 2022

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Background Plasmacytoid and myeloid dendritic cells play a vital role in the protection against viral infections. In COVID-19, there is an impairment of dendritic cell (DC) function and interferon secretion which has been correlated with disease severity. Results In this study, we described the frequency of DC subsets and the plasma levels of Type I (IFNα, IFNβ) and Type III Interferons (IFNλ1), IFNλ2) and IFNλ3) in seven groups of COVID-19 individuals, classified based on days since RT-PCR confirmation of SARS-CoV2 infection. Our data shows that the frequencies of pDC and mDC increase from Days 15–30 to Days 61–90 and plateau thereafter. Similarly, the levels of IFNα, IFNβ, IFNλ1, IFNλ2 and IFNλ3 increase from Days 15–30 to Days 61–90 and plateau thereafter. COVID-19 patients with severe disease exhibit diminished frequencies of pDC and mDC and decreased levels of IFNα, IFNβ, IFNλ1, IFNλ2 and IFNλ3. Finally, the percentages of DC subsets positively correlated with the levels of Type I and Type III IFNs. Conclusion Thus, our study provides evidence of restoration of homeostatic levels in DC subset frequencies and circulating levels of Type I and Type III IFNs in convalescent COVID-19 individuals.

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“…In contrast, a recent report suggested that pDC accumulation in the lung during viral infection facilitates type 2 allergic airway exacerbations in an OVA-driven model, with Ab-mediated depletion of pDCs reducing type 2 cytokines in the draining LNs (dLNs) (28). In humans, along with cDCs, pDC numbers in the blood are increased during infection with the soil-transmitted nematode Strongyloides stercoralis, compared with numbers in endemic healthy and anthelmintictreated individuals (29). We previously demonstrated that unlike reports from allergic airway models, negative regulation of type 2 inflammation is not a hallmark pDC function in the early stages of S. mansoni infection (6).…”

Section: Introductionmentioning

confidence: 96%

Plasmacytoid Dendritic Cells Facilitate Th Cell Cytokine Responses throughout Schistosoma mansoni Infection

et al. 2021

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Plasmacytoid dendritic cells (pDCs) are potent producers of type I IFN (IFN-I) during viral infection and respond to IFN-I in a positive feedback loop that promotes their function. IFN-I shapes dendritic cell responses during helminth infection, impacting their ability to support Th2 responses. However, the role of pDCs in type 2 inflammation is unclear. Previous studies have shown that pDCs are dispensable for hepatic or splenic Th2 responses during the early stages of murine infection with the trematode Schistosoma mansoni at the onset of parasite egg laying. However, during S. mansoni infection, an ongoing Th2 response against mature parasite eggs is required to protect the liver and intestine from acute damage and how pDCs participate in immune responses to eggs and adult worms in various tissues beyond acute infection remains unclear. We now show that pDCs are required for optimal Th2 cytokine production in response to S. mansoni eggs in the intestinal-draining mesenteric lymph nodes throughout infection and for eggspecific IFN-g at later time points of infection. Further, pDC depletion at chronic stages of infection led to increased hepatic and splenic pathology as well as abrogated Th2 cell cytokine production and activation in the liver. In vitro, mesenteric lymph node pDCs

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Elevated Systemic and Parasite—Antigen Stimulated Levels of Type III IFNs in a Chronic Helminth Infection and Reversal Following Anthelmintic Treatment

Cited by 4 publications

References 32 publications

Association of previous schistosome infection with fatty liver and coronary heart disease: A cross‐sectional study in china

Association of previous schistosome infection with fatty liver and coronary heart disease: A cross‐sectional study in china

Restoration of dendritic cell homeostasis and Type I/Type III interferon levels in convalescent COVID-19 individuals

Plasmacytoid Dendritic Cells Facilitate Th Cell Cytokine Responses throughout Schistosoma mansoni Infection

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