Elevated total serum IgE in vitiligo might be protective for other autoimmune diseases

Inverse association between autoimmunity and elevated IgE among childhood vitiligo

“…The elevated IgE level was significantly associated with atopic disease history and negatively associated with personal autoimmune history. This finding was consistent with the study by Marti et al., which also showed that elevated IgE indicates low autoimmunity 27 . The current sample size might not be sufficiently large, and the positive rate of the variables is not high, which could influence the power of statistics.…”

“…This finding was consistent with the study by Marti et al, which also showed that elevated IgE indicates low autoimmunity. 27 The current sample size might not be sufficiently large, and the positive rate of the variables is not high, which could influence the power of statistics. Interestingly, inverse trends are noted between several autoimmune conditions and elevated IgE; for example, none of the eight abnormal thyroid function patients had elevated IgE.…”

Factors associated with perceived stress in patients with vitiligo in the ComPaRe e-cohort

“…Indeed, we have previously shown that patients with vitiligo with atopy experienced more pruritus that could influence the Koebner phenomenon type I, which could be significant in the initiation of vitiligo. 4 In our cohort, important stress at work (16.6%) and the death of a loved one (9%) are the most common stressful life events reported among adult patients with vitiligo, and such events are consistently associated with poor quality of life and depression. Indeed, the frequent association of vitiligo with psychiatric comorbidities is not surprising as not only do patients with vitiligo lose their skin color but they may also be more prone to disease worsening related to stress leading to an internal loop.…”