Elevated umbilical cord blood leukocyte cyclic adenosine monophosphate-phosphodiesterase activity in children with atopic parents

Heskel, Neil S.; Chan, Sai C.; Thiel, Marcella L.; Stevens, Seth R.; Casperson, L.S.; Hanifin, Jon M.

doi:10.1016/s0190-9622(84)70184-8

Cited by 66 publications

(19 citation statements)

References 17 publications

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“…This theory was recently supported by the finding that leukocytes from patients with atopic dermatitis have low levels of phosphodiesterase, which in turn would result in increased levels of cyclic AMP [8]. The finding that newborn infants of atopic parents have lower levels of phosphodiesterase in cord blood leukocytes than babies of nonatopic parents indicates that the abnor mality is primary and not secondary to atopic disease or treatment [9].…”

Section: Introductionmentioning

confidence: 94%

Intrauterine Exposure to the Beta-Adrenergic Receptor-Blocking Agent Metoprolol and Allergy

Björkstén

Finnström²,

Wichman³

1988

Int Arch Allergy Immunol

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Cord blood IgE levels and the development of allergy were studied in 29 children born by mothers who had been treated with the β-adrenergic receptor blocking agent, metoprolol, during the pregnancy and in 23 children of placebo-treated mothers. In 13 (45%) of the former and 3 (15%) of the placebo group elevated cord blood IgE levels, i.e. more than 0.9 kU/l and/or obvious or probable allergy developed (p = 0.03). The findings support previous experimental observations that β-blocking agents may enhance IgE antibody formation. It also adds to the number of environmental factors that may increase the risk for atopic disease in children.

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Section: Introductionmentioning

confidence: 94%

Intrauterine Exposure to the Beta-Adrenergic Receptor-Blocking Agent Metoprolol and Allergy

Björkstén

Finnström²,

Wichman³

1988

Int Arch Allergy Immunol

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show abstract

“…35 More recently Heskel et al 36 reported that cord blood lymphocytes of newborn infants with a bilateral family history of atopic disease had higher POE concentrations than did lymphocytes of newborn controls. In a collaborative study with Hanifin's group35.36we are prospectively studying the predictive value of POE determinations in infants with and without a family history of atopic disease.…”

Section: Amniotic Fluidmentioning

confidence: 99%

Prediction of Allergy in Infancy

Kjellman¹,

Croner²,

Fälth‐Magnusson³

et al. 1991

allergy asthma proc

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“…We also demonstrated elevated umbilical cord blood leukocyte PDE activity in infants whose parents had atopic disease [21], sttggesting a getietic basis for this abnonnality.…”

Section: Cyclic Nuclbotide Abnoi:uvialitiesmentioning

confidence: 54%

Monocyte Phosphodiesterase Abnormalities and Dysregulation of Lymphoctye Function in Atopic Dermatitis.

Hanifin¹,

Chan²

1995

J Invest Dermatol

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Elevated umbilical cord blood leukocyte cyclic adenosine monophosphate-phosphodiesterase activity in children with atopic parents

Cited by 66 publications

References 17 publications

Intrauterine Exposure to the Beta-Adrenergic Receptor-Blocking Agent Metoprolol and Allergy

Intrauterine Exposure to the Beta-Adrenergic Receptor-Blocking Agent Metoprolol and Allergy

Prediction of Allergy in Infancy

Monocyte Phosphodiesterase Abnormalities and Dysregulation of Lymphoctye Function in Atopic Dermatitis.

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