Elevated urinary lipocalin-2, interleukin-6 and monocyte chemoattractant protein-1 levels in children with congenital ureteropelvic junction obstruction

Yu, Li; Zhou, Lin; Li, Q.; Li, S.; Luo, Xiapu; Zhang, C.; Wu, Bo; Brooks, James D.; Sun, Hong

doi:10.1016/j.jpurol.2018.10.007

Cited by 18 publications

(26 citation statements)

References 25 publications

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“…Clinical interest has focused on the potential uses of urine markers that are associated with various aspects of the pathophysiology of UPJO, such as inflammation, apoptosis, oxidative stress, and fibrosis (10,13,15,27). UPJO is characterized by tubulointerstitial fibrosis in the obstructed kidney, and as previously demonstrated, high levels of inflammation-and fibrosis-related biomarkers in the urine could suggest renal impairment (27)(28)(29).…”

Section: Discussionmentioning

confidence: 99%

Matrix Remodeling-Associated Protein 5 in Urinary Exosomes as a Potential Novel Marker of Obstructive Nephropathy in Children With Ureteropelvic Junction Obstruction

et al. 2020

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Recent investigations have described the use of urinary matrix remodeling-associated protein 5 (MXRA5) as a novel biomarker of kidney impairment in the setting of chronic kidney disease. In this study, we aimed to evaluate the possible clinical application of urinary MXRA5 as a useful non-invasive marker in the urine from the affected renal pelvis and bladder of children with ureteropelvic junction obstruction (UPJO). We conducted a prospective cohort study of patients aged <12 months with prenatally diagnosed unilateral UPJO who underwent dismembered pyeloplasty in 2018 or 2019, and a sex-and age-matched control group of healthy children. Blood urea nitrogen and creatinine levels were normal in all the patients. The whole urine and urinary exosomal concentrations of MXRA5 were measured by enzyme-linked immunosorbent assay. The correlations between bladder/renal pelvic MXRA5 levels and differential renal function (DRF) in the affected kidney were also determined. A total of 35 UPJO patients and 12 controls were enrolled in the study. There was no significant difference in whole-urine MXRA5 level between the controls and UPJO patients. However, the exosomal MXRA5 level was significantly lower in the controls than in patients with UPJO (p < 0.05). There were non-significant correlations between bladder and renal pelvis whole-urine MXRA5 levels and DRF (R 2 = 0.1115, p = 0.05 and R 2 = 0.3313, p = 0.0502, respectively). The strongest correlation was between exosomal MXRA5 level in the renal pelvis and DRF (R 2 = 0.8128, p < 0.0001). Urinary exosomal MXRA5 level was significantly higher in children with UPJO than controls. Higher urinary exosomal MXRA5 levels were significantly correlated with lower DRF in the affected kidney in children with UPJO.

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Section: Discussionmentioning

confidence: 99%

Matrix Remodeling-Associated Protein 5 in Urinary Exosomes as a Potential Novel Marker of Obstructive Nephropathy in Children With Ureteropelvic Junction Obstruction

et al. 2020

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“…The serum or urine NGAL level is a clinically useful biomarker of various types of AKI, including AKI after kidney transplantation [ 42 ], contrast medium-induced AKI [ 43 ], and AKI in critical care settings [ 44 ]. In children with UUTO, urine NGAL levels are significantly higher in bladder urine and/or renal pelvic urine compared to controls, correlate inversely with worsening obstruction, and decrease after surgery ( Table 1 ) [ 26 , 36 , 45 , 46 , 47 , 48 , 49 ]. The AUC-ROC value for UUTO in children is 0.61–0.90 for bladder urine NGAL [ 26 , 36 , 45 , 46 , 47 , 48 ].…”

Section: Biomarkers Of Uutomentioning

confidence: 99%

“…In children with UUTO, urine NGAL levels are significantly higher in bladder urine and/or renal pelvic urine compared to controls, correlate inversely with worsening obstruction, and decrease after surgery ( Table 1 ) [ 26 , 36 , 45 , 46 , 47 , 48 , 49 ]. The AUC-ROC value for UUTO in children is 0.61–0.90 for bladder urine NGAL [ 26 , 36 , 45 , 46 , 47 , 48 ]. In adults with UUTO, the urine NGAL level increases in those with obstructive nephropathy (AUC-ROCs of 0.70 for bladder urine and 0.76 for renal pelvic urine) and decreases after relief of the obstruction [ 23 , 50 , 51 ].…”

Section: Biomarkers Of Uutomentioning

confidence: 99%

Roles Played by Biomarkers of Kidney Injury in Patients with Upper Urinary Tract Obstruction

Washino

Hosohata

Miyagawa

2020

IJMS

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Partial or complete obstruction of the urinary tract is a common and challenging urological condition caused by a variety of conditions, including ureteral calculi, ureteral pelvic junction obstruction, ureteral stricture, and malignant ureteral obstruction. The condition, which may develop in patients of any age, induces tubular and interstitial injury followed by inflammatory cell infiltration and interstitial fibrosis, eventually impairing renal function. The serum creatinine level is commonly used to evaluate global renal function but is not sensitive to early changes in the glomerular filtration rate and unilateral renal damage. Biomarkers of acute kidney injury are useful for the early detection and monitoring of kidney injury induced by upper urinary tract obstruction. These markers include levels of neutrophil gelatinase-associated lipocalin (NGAL), monocyte chemotactic protein-1, kidney injury molecule 1, N-acetyl-b-D-glucosaminidase, and vanin-1 in the urine and serum NGAL and cystatin C concentrations. This review summarizes the pathophysiology of kidney injury caused by upper urinary tract obstruction, the roles played by emerging biomarkers of obstructive nephropathy, the mechanisms involved, and the clinical utility and limitations of the biomarkers.

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“…In the existing literature, elevated LCN2 was also detected in the aqueous humor of patients with idiopathic acute anterior uveitis [9] and central retinal vein occlusion [10] and vitreous fluid from patients with rhegmatogenous retinal detachment [11]. A large number of studies indicate that the level of LCN2 is closely related to the degree of inflammation in various inflammatory diseases [12][13][14][15][16][17]. However, LCN2 level in vitreous fluid and the relation with other inflammatory cytokines such as vascular endothelial growth factor (VEGF) in diabetic patients with DR or PDR remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Elevated vitreous Lipocalin-2 levels of patients with proliferative diabetic retinopathy

Wang

Liu

et al. 2020

BMC Ophthalmol

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Background: Lipocalin-2 (LCN2) is a novel adipokine with potential roles in obesity, insulin resistance, and inflammation. This study aims to assess the concentrations of LCN2 and vascular endothelial growth factor (VEGF) expressed in the vitreous humors of patients with proliferative diabetic retinopathy (PDR). Methods: The concentrations of LCN2 and VEGF were measured from the vitreous of 67 patients undergoing vitrectomy (20 controls and 47 PDR) via enzyme-linked immunosorbent assay (ELISA). Patients with non-ocular pathology that could elevate the LCN2 level in the vitreous were excluded. PDR activity and a history of panretinal photocoagulation were used for further grouping analysis. Results: The vitreous concentration of LCN2 was statistically significantly higher in the PDR group compared to the control group (63,522 (30,009) pg/ml versus 1663 (1191) pg/ml, respectively; P < 0.001). VEGF level was also significantly higher in the PDR group than in the control group (1038 (1326) pg/ml versus 9 pg/ml, respectively; P < 0.001). The mean vitreous LCN2 and VEGF levels in active PDR patients were significantly higher than that of the inactive PDR patients. The mean LCN2 concentration in vitreous humor was significantly lower in the 28 PDR patients with a history of complete PRP (37,304 (16,651) pg/mL) in comparison with 19 PDR patients without preperformed panretinal photocoagulation or with preperformed incomplete panretinal photocoagulation (79,796 (24,391) pg/mL). A significant correlation between the vitreous LCN2 level and VEGF level was found in patients with PDR (R = 0.34; P = 0.019). Conclusions: This report shows a significant increase of LCN2 in the vitreous fluid of patients with PDR and present a significant correlation between LCN2 and VEGF, suggesting LCN2 might be involved in the pathogenesis of PDR.

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Elevated urinary lipocalin-2, interleukin-6 and monocyte chemoattractant protein-1 levels in children with congenital ureteropelvic junction obstruction

Abstract: Fig Ratio of urinary biomarker concentrations to urinary creatinine levels in patients with unilateral and bilateral UPJO.

Cited by 18 publications

References 25 publications

Matrix Remodeling-Associated Protein 5 in Urinary Exosomes as a Potential Novel Marker of Obstructive Nephropathy in Children With Ureteropelvic Junction Obstruction

Matrix Remodeling-Associated Protein 5 in Urinary Exosomes as a Potential Novel Marker of Obstructive Nephropathy in Children With Ureteropelvic Junction Obstruction

Roles Played by Biomarkers of Kidney Injury in Patients with Upper Urinary Tract Obstruction

Elevated vitreous Lipocalin-2 levels of patients with proliferative diabetic retinopathy

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