Elevated whole blood manganese is associated with impaired cognition in older adults, NHANES 2013–2014 cycle

Larvie, Doreen; Erikson, Keith M.; Armah, Seth M.

doi:10.1016/j.neuro.2022.04.016

Cited by 6 publications

(5 citation statements)

References 21 publications

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“…A meta-analysis of 17 epidemiologic studies found a significant decrease in serum Mn concentration in the cognitive impairment group (AD or MCI patients) compared to healthy controls (standardized mean difference: −0.37; 95% CI: −0.6 to −0.13) [36]. Contrarily, excess exposure to Mn was also a risk factor for neurodegeneration, thus explaining the U-shaped relationship found in our results [35].…”

Section: Discussionsupporting

confidence: 59%

“…Previous studies have shown a considerable effect of Mn on cognitive impairment [35,36]. Larvie et al (2022) analyzed the 2013-2013 NHANES data and found that the digit symbol substitution test score was inversely associated with blood Mn among the subjects in the highest quartile (p = 0.003) [35]. A meta-analysis of 17 epidemiologic studies found a significant decrease in serum Mn concentration in the cognitive impairment group (AD or MCI patients) compared to healthy controls (standardized mean difference: −0.37; 95% CI: −0.6 to −0.13) [36].…”

Section: Discussionmentioning

confidence: 97%

“…Our findings showed a downward trend of cognitive impairment odds as the mixed ETE concentration increased through the visual exploration of BKMR-P. We found that Mn in the multi-exposure model was the most significant contributor to CIND, showing a Ushaped relationship between them. Previous studies have shown a considerable effect of Mn on cognitive impairment [35,36]. Larvie et al (2022) analyzed the 2013-2013 NHANES data and found that the digit symbol substitution test score was inversely associated with blood Mn among the subjects in the highest quartile (p = 0.003) [35].…”

Section: Discussionmentioning

confidence: 99%

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Association between Multiple Trace Elements, Executive Function, and Cognitive Impairment with No Dementia in Older Adults

Ryoo,

Choi,

Son

et al. 2024

Nutrients

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Many studies suggest a significant association between individual essential trace elements (ETEs) and cognitive impairment in older adults, but evidence of the synchronized effect of multiple ETEs on cognitive function is lacking. We investigated the association between multiple ETEs, cognitive impairment with no dementia (CIND), and executive function in older Korean adults, using the Bayesian kernel machine regression (BKMR) model. Three hundred and thirty-six older adults were included as the study population and classified as the CIND and control groups. Blood manganese (Mn), copper (Cu), zinc (Zn), selenium (Se), and molybdenum (Mo) were measured as relevant ETEs. The frontal/executive tests included digit symbol coding (DSC), the Korean color word Stroop test (K-CWST), a controlled oral word association test (COWAT), and a trial-making test (TMT). Overall, the BKMR showed a negative association between multiple ETEs and the odds of CIND. Mn was designated as the most dominant element associated with the CIND (PIP = 0.6184), with a U-shaped relationship. Cu and Se levels were positively associated with the K-CWST percentiles (β = 31.78; 95% CI: 13.51, 50.06) and DSC percentiles (β = 25.10; 95% CI: 7.66, 42.53), respectively. Our results suggest that exposure to multiple ETEs may be linked to a protective mechanism against cognitive impairment in older adults.

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Association between Multiple Trace Elements, Executive Function, and Cognitive Impairment with No Dementia in Older Adults

Ryoo,

Choi,

Son

et al. 2024

Nutrients

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“…As with hereditary hemochromatosis, we speculate that SLC30A10 polymorphisms will impact the susceptibility of individuals with dietary Fe deficiency to development of Mn excess. While we would not expect severe Mn excess in this situation, even moderate increases in blood Mn levels correlate with impaired cognition and therefore may be relevant to the long-term health of individuals with Fe deficiency 48,49 .…”

Section: Discussionmentioning

confidence: 82%

Manganese transporter SLC30A10 and iron transporters SLC40A1 and SLC11A2 impact dietary manganese absorption

Prajapati,

Zhang,

Chong

et al. 2024

Preprint

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SLC30A10 deficiency is a disease of severe manganese excess attributed to loss of SLC30A10-dependent manganese excretion via the gastrointestinal tract. Patients develop dystonia, cirrhosis, and polycythemia. They are treated with chelators but also respond to oral iron, suggesting that iron can outcompete manganese for absorption in this disease. Here we explore the latter observation. Intriguingly, manganese absorption is increased in Slc30a10-deficient mice despite manganese excess. Studies of multiple mouse models indicate that increased dietary manganese absorption reflects two processes: loss of manganese export from enterocytes into the gastrointestinal tract lumen by SLC30A10, and increased absorption of dietary manganese by iron transporters SLC11A2 (DMT1) and SLC40A1 (ferroportin). Our work demonstrates that aberrant absorption contributes prominently to SLC30A10 deficiency and expands our understanding of biological interactions between iron and manganese. Based on these results, we propose a reconsideration of the role of iron transporters in manganese homeostasis is warranted.

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“…Our study focus is groundwater containing elevated concentrations of potentially harmful dissolved geogenic constituents, which are defined as chemicals or isotopes that have geologic or atmospheric sources (although they can also have other sources, as described in the supplemental information and in Erickson et al ( 2024 )). Geogenic trace metals, other trace elements, and radionuclides have been linked to increased cancer risk (Agency for Toxic Substances and Disease Registry, 1999 ; Krajewski et al, 2021 ; Mendez et al, 2017 ) and non-cancer adverse human health outcomes (Agency for Toxic Substances and Disease Registry, 1999 ; Larvie et al, 2022 ; Naujokas et al, 2013 ; Wasserman et al, 2016 ). Because of their widespread occurrence in geologic and other materials, geogenic constituents are among the most prevalent contaminants found in drinking source water, thus limiting drinking water availability in the USA and globally (Smedley & Kinniburgh, 2002 ; Welch et al, 2000 ).…”

Section: Introductionmentioning

confidence: 99%

Prioritizing water availability study settings to address geogenic contaminants and related societal factors

Erickson,

Brown,

Tomaszewski

et al. 2024

Environ Monit Assess

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Water availability for human and ecological uses depends on both water quantity and water quality. The U.S. Geological Survey (USGS) is developing strategies for prioritizing regional-scale and watershed basin-scale studies of water availability across the nation. Previous USGS ranking processes for basin-scale studies incorporated primarily water quantity factors but are now considering additional water quality factors. This study presents a ranking based on the potential impacts of geogenic constituents on water quality and consideration of societal factors related to water quality. High-concentration geogenic constituents, including trace elements and radionuclides, are among the most prevalent contaminants limiting water availability in the USA and globally. Geogenic constituents commonly occur in groundwater because of subsurface water–rock interactions, and their distributions are controlled by complex geochemical processes. Geogenic constituent mobility can also be affected by human activities (e.g., mining, energy production, irrigation, and pumping). Societal factors and relations to drinking water sources and water quality information are often overlooked when evaluating research priorities. Sociodemographic characteristics, data gaps resulting from historical data-collection disparities, and infrastructure condition/age are examples of factors to consider regarding environmental justice. This paper presents approaches for ranking and prioritizing potential basin-scale study areas across the contiguous USA by considering a suite of conventional physical and geochemical variables related to geogenic constituents, with and without considering variables related to societal factors. Simultaneous consideration of societal and conventional factors could provide decision makers with more diverse, interdisciplinary tools to increase equity and reduce bias in prioritizing focused research areas and future water availability studies.

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Elevated whole blood manganese is associated with impaired cognition in older adults, NHANES 2013–2014 cycle

Cited by 6 publications

References 21 publications

Association between Multiple Trace Elements, Executive Function, and Cognitive Impairment with No Dementia in Older Adults

Association between Multiple Trace Elements, Executive Function, and Cognitive Impairment with No Dementia in Older Adults

Manganese transporter SLC30A10 and iron transporters SLC40A1 and SLC11A2 impact dietary manganese absorption

Prioritizing water availability study settings to address geogenic contaminants and related societal factors

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