Elevating the discourse on drug delivery: A fresh perspective on the utilization of coordination chemistry-driven metal-drug conjugates

Biswas, Megha; Kanta Choudhury, Krishna; Banerjee, Arka; Pathak, Rakesh Kumar

doi:10.1016/j.ccr.2024.216026

Coordination Chemistry Reviews

2024

DOI: 10.1016/j.ccr.2024.216026

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Elevating the discourse on drug delivery: A fresh perspective on the utilization of coordination chemistry-driven metal-drug conjugates

Megha Biswas,

Krishna Kanta Choudhury,

Arka Banerjee

et al.

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Cited by 3 publications

References 145 publications

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TTFA-Platin Conjugate: Deciphering the Therapeutic Roles of Combo-Prodrug through Evaluating Stability–Activity Relationship

Biswas,

Chaudhary,

Padhi

et al. 2024

J. Med. Chem.

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This work introduces a novel Pt(II) based prodrug TTFA-Platin that integrates a β-diketonate ligand TTFA with a platinum scaffold to structurally resemble carboplatin and offers intermediate kinetic lability between cisplatin and carboplatin, striking a balance between therapeutic efficacy and safety. A comprehensive stability and speciation study was conducted in various biological media, mapping the therapeutic effects of TTFA-Platin. A control molecule, TMK-Platin, was synthesized to further validate the structural-stability relationship, which displayed poor activatable features in biological systems. In vitro studies against a panel of cancer cell lines revealed that TTFA-Platin exhibited significantly higher potency compared to TMK-Platin. In vivo studies revealed that TTFA-Platin exhibited significantly lower toxicity than the reference platinum compounds. Thus, leveraging ligands that fine-tune kinetic lability and offer therapeutic benefits can help develop more effective and safer cancer treatments, addressing the limitations of existing therapies.

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TTFA-Platin Conjugate: Deciphering the Therapeutic Roles of Combo-Prodrug through Evaluating Stability–Activity Relationship

Biswas,

Chaudhary,

Padhi

et al. 2024

J. Med. Chem.

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Biological activity of vanadium pincer complexes

Delgado-Rangel,

Reyes-Márquez,

Moreno-Narváez

et al. 2025

New J. Chem.

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A Review: Recent Advances in Chemistry and Applications of 2,4-Dihydroxybenzaldehyde Oxime and Its Transition Metal Complexes

Reema Chand,

Mohseen Ahmed,

Bibhesh K. Singh

2024

J. Adv. Chem. Sci.

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This review presents a comprehensive overview of the recent advances in the chemistry and applications of 2,4-dihydroxybenzaldehyde oxime (DHBO) and its transition metal complexes. DHBO, characterized by its unique hydroxyl and oxime functional groups, has gained significant attention due to its versatile reactivity and potential applications across various fields, including pharmaceuticals, catalysis, and environmental science. Recent synthetic methodologies, including microwave-assisted techniques and green chemistry approaches, have improved the efficiency and sustainability of DHBO production. The formation of transition metal complexes with DHBO has been a focal point of research, revealing enhanced catalytic properties and biological activities compared to the free ligand. These complexes have shown promise in organic synthesis, particularly in oxidation and reduction reactions, as well as in drug development, exhibiting antimicrobial and anticancer properties. Furthermore, the potential of DHBO and its metal complexes in environmental remediation, particularly in removing heavy metals and pollutants, underscores their significance in addressing contemporary environmental challenges. This review also provides current knowledge on the synthesis, characterization, and applications of DHBO and its transition metal complexes, highlighting their importance in both academic research and industrial applications. By elucidating the multifaceted roles of DHBO, this work aims to pave the way for future research and innovation in this promising area of study.

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Elevating the discourse on drug delivery: A fresh perspective on the utilization of coordination chemistry-driven metal-drug conjugates

Cited by 3 publications

References 145 publications

TTFA-Platin Conjugate: Deciphering the Therapeutic Roles of Combo-Prodrug through Evaluating Stability–Activity Relationship

TTFA-Platin Conjugate: Deciphering the Therapeutic Roles of Combo-Prodrug through Evaluating Stability–Activity Relationship

Biological activity of vanadium pincer complexes

A Review: Recent Advances in Chemistry and Applications of 2,4-Dihydroxybenzaldehyde Oxime and Its Transition Metal Complexes

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