Elevation of Adipsin, a Complement Activating Factor, in the Mouse Placenta During Spontaneous Abortion

Takeshita, Ai; Kondo, Tomohiro; Okada, Toshiya; Kusakabe, Ken Takeshi

doi:10.1262/jrd.10-036k

Cited by 11 publications

(13 citation statements)

References 20 publications

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“…Previous studies in mice have demonstrated a significant rise in the adipsin levels in aborted placenta. Adipsin is related with the activation of complement pathway, in the decidua fibroblast, which helps with the activation of the defense mechanisms of the extracellular placental tissue 60 . In humans and murines, the activation of C3 and C4 is regulated by DAF and MCP, while in mice, Crry protein participates in this regulation 8 .…”

Section: Discussionmentioning

confidence: 99%

“…In humans and murines, the activation of C3 and C4 is regulated by DAF and MCP, while in mice, Crry protein participates in this regulation 8 . In endometrial samples from mouse miscarriages and human placentas, the expression of DAF, MCP, and Crry proteins has been demonstrated 60 61 . Recently, it has been demonstrated in CBA/J×DBA/2 model mice a significant elevation in serum and placenta adipsin levels and that these levels are related to spontaneous abortion 62 .…”

Section: Discussionmentioning

confidence: 99%

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Serum Adipsin Levels throughout Normal Pregnancy and Preeclampsia

Poveda

Garcés

Ruíz-Linares

et al. 2016

Sci Rep

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Adipsin is a protease produced at high levels by adipose tissue. It is involved in complement activation and metabolic control. The objective of this study was to determine the changes in adipsin levels during different stages of normal pregnancy, and its association with obstetric outcomes, such as preeclampsia. This nested case-control study in a longitudinal cohort included normal pregnant (n = 54) and preeclamptic (n = 18) women, both followed throughout pregnancy. Additionally, some of the normal pregnant women were followed up three months postpartum (n = 18). Healthy non-pregnant women were also studied during their menstrual cycle (n = 20). The results of this study show that in healthy non-pregnant women, adipsin levels did not change significantly during the menstrual cycle. In normal pregnant women, adipsin levels were lower (p < 0.01) when compared with non-pregnant healthy women, but these serum levels increased again during postpartum (p < 0.001). Adipsin levels were significantly elevated in preeclamptic women in late pregnancy (P < 0.01). A significant correlation was not found between leptin and adipsin during the three periods of gestation studied in healthy pregnant and preeclamptic women. Our results suggest that adipsin may be involved in pregnancy-associated metabolic changes. Moreover, the increase of adipsin levels towards late gestation in preeclamptic women could be related to the pathophysiology of this disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Serum Adipsin Levels throughout Normal Pregnancy and Preeclampsia

Poveda

Garcés

Ruíz-Linares

et al. 2016

Sci Rep

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show abstract

“…A characteristic part of these changes seems to be an activation of the innate immune system, including the complement system and natural killer cells [83, 84, 86]. Adipsin (also known as Complement factor D, coded by CFD , upregulated in PREG heifers), has been subject to extra interest as it has been associated with pre-eclampsia and abortion [87–89]. Consequently it seems complement activation may be part of both physiological and pathological immune changes related to pregnancy.…”

Section: Resultsmentioning

confidence: 99%

Long-term effects of prior diets, dietary transition and pregnancy on adipose gene expression in dairy heifers

et al. 2019

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Adipose tissue is highly involved in whole-body metabolism and is the main site for lipid synthesis, storage and mobilization in ruminants. Therefore, knowledge about adipose tissue responses to different diets is important, especially in growing heifers as the feeding regimes of replacement heifers affect their future success as dairy cows. However, at gene expression level such knowledge is limited. As part of a larger feed trial, adipose tissue biopsies from 24 Norwegian Red heifers were collected at 12 months of age (12MO) and at month seven of gestation (PREG) and analyzed by next-generation mRNA sequencing. Between these two sampling points, all heifers had gone through a successful conception and a feed change from four dietary treatments of high or low energy (HE/LE) and protein (HP/LP) content (treatments LPHE, HPHE, LPLE and HPLE) to a low-energy, low-protein pregnancy feed given to all animals. Gene expression differences between different feed treatments at 12MO are described in an earlier publication from our group. The main objectives of this study were to investigate the long-term effects of diets differing in protein and energy density level on gene expression in adipose tissue of growing replacement dairy heifers. To achieve this, we examined the post-treatment effects between the treatment groups at month seven of gestation; 6 months after the termination of experimental feeding, and the long-term gene expression changes occurring in the adipose tissue between 12MO and PREG. Post-treatment group comparisons showed evidence of long-term effects of dietary treatment on adipose gene expression. Differences between protein treatments were smaller than between energy treatments. Adipose gene expression changes from 12MO to PREG were much larger for the HE than the LE treatments and seemed to mostly be explained by the characteristics of the diet change. 97 genes displayed a unidirectional expression change for all groups from 12MO to PREG, and are considered to be treatment-independent, possibly caused by pregnancy or increased age. This study provides candidate genes and key regulators for further studies on pregnancy preservation (TGFB1, CFD ) and metabolic regulation and efficiency (PI3K, RICTOR, MAP4K4,) in dairy cattle.

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“…Well-defined pathological processes include destruction of fetal erythrocytes (Rh antigen, erythroblastosis) and platelets (Human platelet alloantigens (HPA)-1 and HPA-2, alloimmune thrombocytopenia) by maternal antibodies and infections during pregnancy, where activated macrophages secreting high levels of Th1-type cytokines alter the fragile cytokine balance at the maternal-fetal interface [20, 103]. Takeshita et al found that adipsin immunoreactivity was detected either at the decidua basalis in normal placentas or at the placental maze in absorbed placentas [104]. However, they also showed that the quantity of adipsin was increased in the absorbed placentas compared with the normal placentas, suggesting that local expression of adipsin has an effect at the maternal-fetal interface and probably plays a role in spontaneous abortion [104].…”

Section: Immunomodulatory Molecules In Threatened Pregnancymentioning

confidence: 99%

“…Takeshita et al found that adipsin immunoreactivity was detected either at the decidua basalis in normal placentas or at the placental maze in absorbed placentas [104]. However, they also showed that the quantity of adipsin was increased in the absorbed placentas compared with the normal placentas, suggesting that local expression of adipsin has an effect at the maternal-fetal interface and probably plays a role in spontaneous abortion [104]. …”

Section: Immunomodulatory Molecules In Threatened Pregnancymentioning

confidence: 99%

Immunologic Regulation in Pregnancy: From Mechanism to Therapeutic Strategy for Immunomodulation

Chen

Liu

Sytwu

2012

Clinical and Developmental Immunology

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The immunologic interaction between the fetus and the mother is a paradoxical communication that is regulated by fetal antigen presentation and/or by recognition of and reaction to these antigens by the maternal immune system. There have been significant advances in understanding of abnormalities in the maternal-fetal immunologic relationship in the placental bed that can lead to pregnancy disorders. Moreover, immunologic recognition of pregnancy is vital for the maintenance of gestation, and inadequate recognition of fetal antigens may cause abortion. In this paper, we illustrate the complex immunologic aspects of human reproduction in terms of the role of human leukocyte antigen (HLA), immune cells, cytokines and chemokines, and the balance of immunity in pregnancy. In addition, we review the immunologic processes of human reproduction and the current immunologic therapeutic strategies for pathological disorders of pregnancy.

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Elevation of Adipsin, a Complement Activating Factor, in the Mouse Placenta During Spontaneous Abortion

Cited by 11 publications

References 20 publications

Serum Adipsin Levels throughout Normal Pregnancy and Preeclampsia

Serum Adipsin Levels throughout Normal Pregnancy and Preeclampsia

Long-term effects of prior diets, dietary transition and pregnancy on adipose gene expression in dairy heifers

Immunologic Regulation in Pregnancy: From Mechanism to Therapeutic Strategy for Immunomodulation

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