Elevation of alkaline phosphatase in a pregnant patient with antiphospholipid syndrome: HELLP syndrome or not?

Evaluation the effect of placenta on some clinical biochemical parameters during different reproductive periods in New Zealand white female rabbits

“…The peack levels were (48.8, 113.1 and 53.0) U/L respectively, while the lowest levels were (41.6, 98.0 and 47.0) U/L respectively. Group B recorded a significant increment (p <0.01) in the level of enzyme compared with other two groups and there is no significant increment between group A and C , this increment of enzymal level in pregnant female rabbits (group B) resulted from secretion of this enzyme from placenta during pregnancy and this accord with (10,11,12) this enzyme increase during pregnancy also agreed with(13) who found alkaline phosphatase (ALP) increased during pregnancy due to secretion from placenta (produced by the syncytiotrophoblast) as well as agreed with (14) who found that alkaline phosphatase (ALP) can produce from liver, bone, kidney, small intestine and placenta . This result was compatible with (15,16) who mentioned this enzyme will decrease after delivery .The results revealed that means of enzymal levels of ALT in sera of all animals ( A , B and C) were (45.52, 48.08 and 46) U/L respectively ,while the levels of AST were (20.74, 22.68 and 21.84) U/L respectively and for GGT were (6.08, 6.8 and 6.72) U/L respectively .The highest levels of ALT in sera of all animals were (47.6, 49.7 and 48.2) U/L respectively and the levels were (24.3, 26.2 and 25.4) U/L respectively of AST ,while the levels of GGT were (7.7, 8.9 and 8.7) U/L respectively, where as the lowest levels of ALT were (43.2, 46.9 and 44.5) U/L respectively and the levels of AST were (18.1, 19.4 and 19.0) U/L respectively , while GGT levels recorded (4.7, 5.5 and 5.4) U/L respectively .The statistical analysis among enzymal levels of all groups revealed there were no significant AL-Qadisiya Journal of Vet.…”

Association between serum alkaline phosphatase levels in late pregnancy and the incidence of venous thromboembolism postpartum: a retrospective cohort study

“…In pregnant women, ALP levels were found to be almost unchanged or decreased slightly in early pregnancy, increasing slightly in middle pregnancy, peaking in late pregnancy, and declining postpartum. 8 , 20 , 21 In the past, more attention has been paid to the disease risk associated with increased ALP (e.g., cholestasis), although a few studies had reported that decreased ALP was associated with premature birth, stillbirth, and intrauterine growth restriction. 8 , 9 It is easier to overlook the worse maternal and infantile outcomes caused by decreased ALP levels.…”

Investigating gastrointestinal disorders in pregnancy

“…21 Elevated placental ALP may also be seen with antiphospholipid syndrome. 22 Prospective studies in Wales and India each found abnormal liver enzymes in 3.2% of pregnant women. 23,24 The majority of cases of abnormal liver enzymes in both studies were related to pregnancy-specific liver disease (Table 2).…”