2017
DOI: 10.1016/j.hpb.2017.06.011
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Elevation of CA19-9 and CEA is associated with a poor prognosis in patients with resectable gallbladder carcinoma

Abstract: A combination of an elevated preoperative CEA and CA19-9 was associated with a worse prognosis for patients with GBC who underwent resection.

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Cited by 45 publications
(36 citation statements)
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“…CA 19-9 has been studied as a prognostic marker in resectable GBC where it has shown to be of statistically significant benefit. 9,12,13 However, it has not been evaluated before in prognostication of advanced/ metastaic disease status except in one study which inculded all biliary tract malignancies. 14 In this study, there were about 25% GBC patients and the analysis was not done for these patients separately.…”
Section: Discussionmentioning
confidence: 99%
“…CA 19-9 has been studied as a prognostic marker in resectable GBC where it has shown to be of statistically significant benefit. 9,12,13 However, it has not been evaluated before in prognostication of advanced/ metastaic disease status except in one study which inculded all biliary tract malignancies. 14 In this study, there were about 25% GBC patients and the analysis was not done for these patients separately.…”
Section: Discussionmentioning
confidence: 99%
“…These variables were chosen based on prior literature, as well as biological and clinical plausibility. CA 19-9 level has been found to be an independent predictor of poor survival in patients with biliary tree malignancies 18 and GBC specifically, 19 and baseline CA 19-9 level may predict the burden of disease in GBC, particularly above 20 units per milliliter. 20 CA 19-9 level also has been validated as a predictive marker for positive SL in potentially resectable pancreatic cancer, 21 but to our knowledge, this study is the first demonstration of the predictive significance of CA 19-9 in SL for potentially resectable EHBT.…”
Section: Resultsmentioning
confidence: 98%
“…Only a few reports have revealed the clinical usefulness of the preoperative CA19-9 level in GBCa alone [20-22]. Wen et al [20] compared the survival of GBCa patients using a cutoff value of 37 U/mL, which is the upper limit of normal CA19-9. However, this value may not be the best cutoff point in terms of the influence on survival or biological malignancy.…”
Section: Discussionmentioning
confidence: 99%
“…It is now promoted as a reliable test marker for the detection and prognostication of bile duct cancer [15-19]. Although some authors have discussed the utility of the preoperative CA19-9 level based on the upper limit in patients with GBCa [20-22], the optimal evidence-based cutoff value of CA19-9 in terms of prognosis or biological malignancy for detecting advanced GBCa patients who can avoid upfront surgery has not been clarified.…”
Section: Introductionmentioning
confidence: 99%