Elevation of interleukin‐6 levels in cervical secretions as a predictor of preterm delivery

Lange, Melanie; Chen, Frank K.; Wessel, J.; Büscher, Ulrich; Dudenhausen, Joachim W.

doi:10.1034/j.1600-0412.2003.00149.x

Cited by 34 publications

(10 citation statements)

References 20 publications

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“…Many of the reported associations between inflammatory markers and preterm delivery have been based on analyses of amniotic fluid or vaginal or cervical secretions 29–31 . Similarly, associations between serum markers and preterm delivery are frequently detected only in select groups, including those with previous preterm deliveries 13 or those who are symptomatic for preterm delivery at the time of sampling 32,33 .…”

Section: Discussionmentioning

confidence: 99%

Serum Inflammatory Mediators in Pregnancy: Changes After Periodontal Treatment and Association With Pregnancy Outcomes

Michalowicz

Novak

Hodges

et al. 2009

Journal of Periodontology

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Objective To determine: 1) if periodontal treatment in pregnant women before 21 weeks of gestation alters levels of inflammatory mediators in serum; and 2) if changes in these mediators are associated with birth outcomes. Methods 823 pregnant women with periodontitis were randomly assigned to receive scaling and root planing before 21 weeks of gestation or after delivery. Serum obtained between 13 weeks and 16 weeks 6 days (study baseline) and 29–32 weeks gestation was analyzed for C-reactive protein, prostaglandin E2, matrix metalloproteinase-9, fibrinogen, endotoxin, interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor-α. Cox regression, multiple linear regression, t-tests, chi-square and Fisher’s exact tests were used to examine associations between the biomarkers, periodontal treatment, and gestational age at delivery and birthweight. Results 796 women had baseline serum data; 620 had baseline and follow-up serum and birth data. Periodontal treatment did not significantly alter the level of any biomarker (P>0.05). Neither baseline levels nor change from baseline in any biomarker was significantly associated with preterm birth or infant birthweight (P>0.05). In treatment subjects, change in endotoxin was negatively associated with change in probing depth (P<0.05). Conclusions Non-surgical mechanical periodontal treatment in pregnant women delivered before 21 weeks of gestation did not reduce systemic (serum) markers of inflammation. In pregnant women with periodontitis, levels of these markers at 13–17 weeks and 29–32 weeks gestation were not associated with risk for preterm birth or with infant birthweight.

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Section: Discussionmentioning

confidence: 99%

Serum Inflammatory Mediators in Pregnancy: Changes After Periodontal Treatment and Association With Pregnancy Outcomes

Michalowicz

Novak

Hodges

et al. 2009

Journal of Periodontology

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“…In particular, an elevated concentration of IL-6 in the amniotic fluid appears to be a marker of intrauterine infection that causes preterm delivery (19,20).…”

Section: Discussionmentioning

confidence: 99%

Influence of lactoferrin in preventing preterm delivery: A pilot study

Giunta¹,

Giuffrida²,

Mangano

et al. 2011

Mol Med Report

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“…The studies included in the review examined NSAIDs and COX inhibitors for treating threatened preterm labour. [595][596][597][598][599][600][601][602][603][604][605][606][607] Data were available on the following comparisons: 216,218,219,222,223,226,228,231,234 …”

Section: Figure 179 Forest Plot Of the Effects Of Betamimetics Versusmentioning

confidence: 99%

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Honest

Ca²,

Durée³

et al. 2009

Health Technol Assess

189

146

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For primary prevention, an effective, affordable and safe intervention applied to all mothers without preceding testing is likely to be the most cost-effective approach in asymptomatic women in early pregnancy. For secondary prevention among women at risk of preterm labour in later pregnancy, a management strategy based on the results of testing is likely to be more cost-effective. Implementation of a treat-all strategy with simple interventions, such as fish oils, would be premature for asymptomatic women. Universal provision of high-quality ultrasound machines in labour wards is more strongly indicated for predicting spontaneous preterm birth among symptomatic women than direct management, although staffing issues and the feasibility and acceptability to mothers and health providers of such strategies need to be explored. Further research should include investigations of low-cost and effective tests and treatments to reduce and delay spontaneous preterm birth and reduce the risk of perinatal mortality arising from preterm birth.

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Elevation of interleukin‐6 levels in cervical secretions as a predictor of preterm delivery

Abstract: Cervical IL-6 is a new, promising diagnostic tool to identify patients at high risk of preterm delivery.

Cited by 34 publications

References 20 publications

Serum Inflammatory Mediators in Pregnancy: Changes After Periodontal Treatment and Association With Pregnancy Outcomes

Serum Inflammatory Mediators in Pregnancy: Changes After Periodontal Treatment and Association With Pregnancy Outcomes

Influence of lactoferrin in preventing preterm delivery: A pilot study

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

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