Elevation of Intracellular Ca2+ Level by Triclosan in Rat Thymic Lymphocytes: Increase in Membrane Ca2+ Permeability and Induction of Intracellular Ca2+ Release

Tamura, Ikumi; Saito, Minoru; Nishimura, Yumiko; Satoh, Masaya; Yamamoto, Hiroshi; Oyama, Yasuo

doi:10.1248/jhs.57.540

Cited by 6 publications

(3 citation statements)

References 36 publications

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“…In the present study, we found that triclosan increased cytosolic [Ca 2+ ] i in vascular smooth muscle cells (A10 cells). There are several studies showing that triclosan is able to alter/elevate intracellular free Ca 2+ levels in animal and human cell lines 3 , 18 . Cherednichenko et al 17 reported that triclosan depressed excitation–contraction coupling, inhibited L-type Ca 2+ currents, and Ca 2+ transients in cardiac muscle, indicating that the regulation of triclosan on Ca 2+ signals in smooth muscle and cardiac muscle was through distinct mechanism.…”

Section: Discussionmentioning

confidence: 99%

Mitochondrial uncoupler triclosan induces vasorelaxation of rat arteries

Zhang

et al. 2017

Acta Pharmaceutica Sinica B

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Our previous studies found that mitochondrial uncouplers induced vasodilation. Triclosan, the broad spectrum antibacterial agent, is the active ingredient in soaps and toothpastes. It was reported that triclosan induced mitochondrial uncoupling, so we aim to investigate the effects of triclosan on vascular function of rat mesenteric arteries and aorta. The isometric tension of rat mesenteric artery and thoracic aorta was recorded by multi-wire myograph system. The cytosolic [Ca2+]i, mitochondrial reactive oxygen species (mitoROS), and mitochondrial membrane potential of smooth muscle cells (A10 cells) were measured using laser scanning confocal microscopy. Triclosan treatment relaxed phenylephrine (PE)- and high K+ (KPSS)-induced constriction, and pre-treatment with triclosan inhibited PE- and KPSS-induced constriction of rat mesenteric arteries. In rat thoracic aorta, triclosan also relaxed PE- and KPSS-induced constriction. Triclosan induces vasorelaxation without involving KATP channel activation in smooth muscle cells of arteries. Triclosan treatment increased cytosolic [Ca2+]i, mitochondrial ROS production and depolarized mitochondrial membrane potential in A10 cells. In conclusion, triclosan induces mitochondrial uncoupling in vascular smooth muscle cells and relaxes the constricted rat mesenteric arteries and aorta of rats. The present results suggest that triclosan would indicate vasodilation effect if absorbed excessively in vivo.

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Section: Discussionmentioning

confidence: 99%

Mitochondrial uncoupler triclosan induces vasorelaxation of rat arteries

Zhang

et al. 2017

Acta Pharmaceutica Sinica B

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“…Triclosan (TCS), 5-chloro-2-(2,4-dichloro phenoxy) phenol, is an endocrine-disrupting chemical often used as an antiseptic, disinfectant, or preservative [ 1 , 2 , 3 , 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…In the European Union, 85% of triclosan is used in personal care products (e.g., soaps, toothpaste, mouthwash, and cosmetics), and 10% in plastics and food contact materials (household utensils), while the remaining 5% is used in textiles (antibacterial clothing) [ 1 , 2 , 3 , 4 , 5 , 11 ]. It is also used as a suture coating, but only contributes 0.00016% of the overall TCS global exposure [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Triclosan and Its Consequences on the Reproductive, Cardiovascular and Thyroid Levels

Marques

Mariana

Cairrão

2022

IJMS

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Hygiene is essential to avoid diseases, and this is thanks to daily cleaning and disinfection habits. Currently, there are numerous commercial products containing antimicrobial agents, and although they are efficient in disinfecting, it is still not known the effect of the constant use of these products on human health. In fact, a massive use of disinfectants has been observed due to COVID-19, but the possible adverse effects are not yet known. Triclosan is one of the antimicrobial agents used in cosmetic products, toothpaste, and disinfectants. This compound is an endocrine disruptor, which means it can interfere with hormonal function, with its estrogenic and androgenic activity having already been stated. Even if the use of triclosan is well-regulated, with the maximum allowed concentration in the European Union of 0.3% (m/m), its effects on human health are still uncertain. Studies in animals and humans suggest the possibility of harmful health outcomes, particularly for the reproductive system, and in a less extent for the cardiovascular and thyroid functions. Thus, the purpose of this review was to analyse the possible implications of the massive use of triclosan, mainly on the reproductive and cardiovascular systems and on the thyroid function, both in animals and humans.

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