Elevation of isoprostanes in polycystic ovary syndrome and its relationship with cardiovascular risk factors

Calzada, M C; López-Riquelme, Natividad; Noguera, José Antonio; Mendiola, Jaime; Torres, A. Martínez

doi:10.1007/s40618-018-0888-y

Cited by 5 publications

(3 citation statements)

References 56 publications

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“…The present study shows statistically no significantly higher serum levels of 8-Isoprostane in women with PCOS compared with controls. The present study showed no evidence that the 8-Isoprostane used to evaluate oxidative stress in association with risk factors of CVD, which is not consistent with the commonly held notion that oxidative stress significantly contributes to CVD where there were no statistically significant between 8-Isoprostane with another parameter and the results of this study were that 8-Isoprostane levels showed negative weak correlate with most parameters in patients and this was not consistent with the previous study which showed presence association between 8-Isoprostane with higher CV risk in women with polycystic ovary syndrome [7] .…”

Section: Discussioncontrasting

confidence: 99%

“…Isoprostane is a group of compounds create via encouraging of free radicals for non-enzymatic peroxidation of arachidonic acid that is similar to prostaglandins [6] . Since Isoprostane's discovery by Roberts and Morrow in 1990 [7] , proposed many studies the good biomarker reliable for endogenous lipid peroxidation is the level of Isoprostane, consequently in vivo is important tool reverse the damage and oxidative status [6] . The high concentrations of 8-Isoprostane promote atherosclerosis and cardiovascular disease.…”

Section: Annals Of Tropical Medicine and Publicmentioning

confidence: 99%

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The association of isoprostane levels with cardiovascular disease risk factors in Iraqi women with polycystic ovary syndrome

Khudhair¹,

Taha²

2020

ATMPH

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The current study emphasis assay the association of 8-Isoprostane levels with cardiovascular disease risk factors in polycystic ovary syndrome patients, which is conceder as a current endocrine metabolic disorder that uncovers many serious rates outcomes to female good health, inclusively terrible ratio of infertility. This study including a total of 90 women divided into two groups (50 PCOS patients and 40 healthy controls). Homeostasis model assessment (HOMA-IR), lipid parameters, atherogenic index of plasma (AIP) as well as anthropometric measurements were measured. The level of 8-Isoprostane in serum was measured by a commercially available ELISA kit. The level of 8-Isoprostane was no significantly higher in women with polycystic ovary syndrome (61.97±51.86 pg/mL) compared with the healthy control group (52.44±28.49 pg/mL) (p˃0.05). There were significantly higher in the mean of insulin, homeostatic model assessment for insulin resistance, triglycerides and atherogenic index of plasma in polycystic ovary syndrome patients than the control group (p˂0.05). There was no correlation between 8-Isoprostane with any parameter in patients with polycystic ovary syndrome as showed the Pearson correlation analyses. In conclusion, increased levels of serum 8-Isoprostane are not associated with elevated CV risk in women with polycystic ovary syndrome.

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Section: Discussioncontrasting

confidence: 99%

Section: Annals Of Tropical Medicine and Publicmentioning

confidence: 99%

The association of isoprostane levels with cardiovascular disease risk factors in Iraqi women with polycystic ovary syndrome

Khudhair¹,

Taha²

2020

ATMPH

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“…Additionally, conditions such as cardiovascular, neurological, and respiratory disorders have been linked to high levels of IsoP. 12 Antioxidant defenses, physical defenses, and preventative and repair processes are all components of protective physiological mechanisms against oxidants. Antioxidants are chemicals that can neutralize, scavenge, or stop oxidants from forming.…”

Section: Oxidative Stress In Polycystic Ovarian Syndromementioning

confidence: 99%

The Association of Cardiovascular Disease Risk in Polycystic Ovarian Syndrome: A Qualitative Systematic Review

Kumar,

Acharya,

Acharya

et al. 2023

Journal of South Asian Federation of Obstetrics and Gynaecology

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Polycystic ovarian syndrome (PCOS) is a complex hormonal imbalance with increased amounts of androgen, luteinizing hormone, and insulin. It shows various symptoms like acne, hirsutism, irregular menstruation, and obesity. Besides these, it is accompanied by hyperinsulinemia, hyperandrogenism, hyperlipidemia, anovulation, and insulin resistance. More recently PCOS has been increasingly linked with the development of cardiovascular and thrombotic risks compared to normal women of the same age. According to research so far, PCOS women experience a considerable increase in oxidative stress (OS), which causes many of the metabolic and cardiovascular abnormalities that characterize this condition. In this article, we address the risks associated with both established and emerging cardiovascular risk factors, as well as the various research that suggests women with PCOS may be more susceptible for developing thrombosis and cardiovascular disease (CVD).

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Biomarkers in polycystic ovary syndrome

Huffman,

Rezq,

Basnet

et al. 2023

Current Opinion in Physiology

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Elevation of isoprostanes in polycystic ovary syndrome and its relationship with cardiovascular risk factors

Abstract: Patients with polycystic ovary syndrome have higher 8-isoprostanes levels and it is associated with several cardiovascular risk factors.

Cited by 5 publications

References 56 publications

The association of isoprostane levels with cardiovascular disease risk factors in Iraqi women with polycystic ovary syndrome

The association of isoprostane levels with cardiovascular disease risk factors in Iraqi women with polycystic ovary syndrome

The Association of Cardiovascular Disease Risk in Polycystic Ovarian Syndrome: A Qualitative Systematic Review

Biomarkers in polycystic ovary syndrome

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