2019
DOI: 10.1038/s41419-019-1577-2
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Elevation of O-GlcNAc and GFAT expression by nicotine exposure promotes epithelial‐mesenchymal transition and invasion in breast cancer cells

Abstract: Cigarette smoking has been shown to be a carcinogenic factor in breast cancer. Nicotine (Nic), an active component of tobacco, has been found to induce epithelial-mesenchymal transition (EMT) in breast cancer cells. However, the alterations in protein O-GlcNAcylation in Nic-mediated tumorigenesis and malignization mechanisms are less well studied. Herein, we found that cellular O-GlcNAcylation dramatically increased in human breast cancer cells with EMT activation induced by Nic. Elevated O-GlcNAcylation subse… Show more

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Cited by 24 publications
(19 citation statements)
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“…During the EMT process, tumor cells change from an epithelioid morphology to a mesenchymal morphology, and exhibit decreases in epithelial markers, such as E-cadherin (E-cad) and claudin-1 [ 10 ], and increases in mesenchymal markers, such as vimentin (Vim) and n-cadherin (N-cad), as well as EMT- related transcription factors, such as Twist1/2, the Slug/Snail family, and ZEB1/2 [ 9 ]. Nic can stimulate EMT and increase the aggressiveness of many types of cancer [ 11 , 12 ]. To date, it is unclear if Nic-induced EMT phenotypes occurs in the development of PDAC, and the mechanisms by which Nic may contribute to EMT and progression in PDAC are not completely known.…”
Section: Introductionmentioning
confidence: 99%
“…During the EMT process, tumor cells change from an epithelioid morphology to a mesenchymal morphology, and exhibit decreases in epithelial markers, such as E-cadherin (E-cad) and claudin-1 [ 10 ], and increases in mesenchymal markers, such as vimentin (Vim) and n-cadherin (N-cad), as well as EMT- related transcription factors, such as Twist1/2, the Slug/Snail family, and ZEB1/2 [ 9 ]. Nic can stimulate EMT and increase the aggressiveness of many types of cancer [ 11 , 12 ]. To date, it is unclear if Nic-induced EMT phenotypes occurs in the development of PDAC, and the mechanisms by which Nic may contribute to EMT and progression in PDAC are not completely known.…”
Section: Introductionmentioning
confidence: 99%
“…Hexosamines are a family of molecules composed of simple sugars and nitrogen groups [18]. Specifically, glutamine amide is used in the HBP, where it is conjugated with fructose-6-phosphate to form glucosamine-6-phosphate by glutamine:fructose-6-phosphate amidotransferase (GFPT1 gene) [18,79]. The final product of the HBP is uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), which is used as a substrate for protein glycosylation [79,80].…”
Section: C-myc's Regulation Of the Hexosamine Biosynthesis Pathway And Protein Glycosylationmentioning
confidence: 99%
“…Specifically, glutamine amide is used in the HBP, where it is conjugated with fructose-6-phosphate to form glucosamine-6-phosphate by glutamine:fructose-6-phosphate amidotransferase (GFPT1 gene) [18,79]. The final product of the HBP is uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), which is used as a substrate for protein glycosylation [79,80]. During this process, proteins at serine and threonine residues are O-link GlcNAcylated by O-GlcNAc transferase (OGT) [79,80].…”
Section: C-myc's Regulation Of the Hexosamine Biosynthesis Pathway And Protein Glycosylationmentioning
confidence: 99%
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