Elevation of Platelet Count in Patients with Colorectal Cancer Predicts Tendency to Metastases and Poor Prognosis

Lin, Mao Song; Huang, Jun; Zhu, Jiayi; Shen, Hong

doi:10.5754/hge12277

Cited by 36 publications

(31 citation statements)

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“…In addition, platelets release PDGF, which is a potent inducer of tumor cell invasion (31). Therefore, high platelet counts were reported to be associated with tumor progression and poor prognosis in numerous types of cancer (32,33).…”

Section: Discussionmentioning

confidence: 99%

Low local blood perfusion, high white blood cell and high platelet count are associated with primary tumor growth and lung metastasis in a 4T1 mouse breast cancer metastasis model

et al. 2015

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Abstract. It was originally thought that no single routine blood test result would be able to indicate whether or not a patient had cancer; however, several novel studies have indicated that the median survival and prognosis of cancer patients were markedly associated with the systemic circulation features of cancer patients. In addition, certain parameters, such as white blood cell (WBC) count, were largely altered in malignant tumors. In the present study, routine blood tests were performed in order to observe the change of blood cells in tumor-bearing mice following the implantation of 4T1 breast cancer cells into the mammary fat pad; in addition, blood flow in breast tumor sites was measured indirectly using laser Doppler perfusion imaging (LDPI), in an attempt to explain the relevance between the blood circulation features and the growth or metastasis of breast cancer in mice model. The LDPI and blood test results indicated that the implantation of 4T1 breast cancer cells into BALB/c mice led to thrombosis as well as high WBC count, high platelet count, high plateletcrit and low blood perfusion. Following implantation of the 4T1 cells for four weeks, the lung metastatic number was determined and the Pearson correlation coefficient revealed that the number of visceral lung metastatic sites had a marked negative association with the ratio of basophils (BASO%; r=-0.512; P<0.01) and the mean corpuscular hemoglobin was significantly correlated with primary tumor weight (r=0.425; P<0.05). In conclusion, the results of the present study demonstrated that tumor growth led to thrombosis and acute anemia in mice; in addition, when blood BASO% was low, an increased number of lung metastases were observed in tumor-bearing mice. IntroductionOver the past several decades, developments in clinical and surgical treatments for cancer patients has led to increased overall survival rates (1). However, the growth of primary tumors and subsequent cancer metastases continue to cause mortality and prevent effective treatment (2). Vascular dissemination is a major mechanism by which breast cancer cells migrate into the systemic circulation, leading to distant metastasis and mortality (3). Clinical observations have indicated a potential association between the bloodstream and cancer metastasis (4-5). However, few studies have investigated the systemic circulation characterization in mouse breast cancer metastasis models, which therefore limits the development of experimental oncology research.Cancer patients have frequently been reported to present with symptoms of thrombosis, which are more severe if the disease has progressed to a metastatic stage (6,7). In order for metastases to form, cancer cells must be able to survive in the harsh circulatory environment and extravasate into distant sites. Thrombosis may improve the anchoring of 'seed' (tumor cells that have escaped surgical removal or that may have already disseminated) to 'soil' (target organ) (8). Therefore,

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Section: Discussionmentioning

confidence: 99%

Low local blood perfusion, high white blood cell and high platelet count are associated with primary tumor growth and lung metastasis in a 4T1 mouse breast cancer metastasis model

et al. 2015

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“…Previous studies showed that the increased platelet count was associated with poor prognosis in nasopharyngeal carcinoma (Gao et al, 2013), gastric cancer (Hwang et al, 2012), colorectal cancer (Lin et al, 2012), and endometrial carcinomas (Gorelick et al, 2009). Our study found that the elevated values of platelet-based indices predicted poor survival for HCC patients after resection, which was consistent with the findings in other cancers.…”

Section: Discussionmentioning

confidence: 98%

Prognostic Evaluation of Categorical Platelet-based Indices Using Clustering Methods Based on the Monte Carlo Comparison for Hepatocellular Carcinoma

Guo

Shen²,

Zhang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…A total of 20 studies (7,(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) that met the inclusion criteria were retrieved for analysis in the present study. The selection process of the included studies is presented in Fig.…”

Section: Identification Of Eligible Studiesmentioning

confidence: 99%

The clinicopathological and prognostic role of thrombocytosis in patients with cancer: A meta-analysis

Zhang

et al. 2017

Oncology Letters

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Abstract. Previous studies have linked the presence of thrombocytosis with the progression and development of cancer; however, this trend requires further investigation. The present study aimed to derive an estimation of the degree of association between thrombocytosis and the 5-year overall survival rate of patients with cancer, as well as common clinicopathological features, by performing a meta-analysis of 20 (n=12,778) published studies. The PubMed and Embase databases were searched systematically for all relevant articles published in English. Odds ratios (ORs) with 95% confidence intervals (CI) were calculated using a fixed effects or random effects model to evaluate the degree of the observed associations. The results suggested that thrombocytosis (platelet count, >400x10 9 /l) correlated with a decreased 5-year overall survival rate (OR=2.70, 95% CI=2.03-3.61) and an advanced tumor-node-metastasis stage (III + IV; OR=2.14, 95% CI=1.58-2.90). Furthermore, these associations remained robust following stratification of the data by cancer type and ethnicity. In addition, thrombocytosis (platelet count, >300x10 9 /l) correlated with a decreased 5-year overall survival rate in patients with colorectal cancer (OR=3.49, 95% CI=1. 44-8.46). Although certain biases were not able to be eliminated, the present meta-analysis suggested that thrombocytosis is a valuable indicator for the evaluation of pathological diagnosis and prognosis for patients with cancer. Further studies are required to investigate the effect of thrombocytosis on the prognosis of patients with cancer. IntroductionDespite improvements in early diagnosis, radical surgery and various novel treatments, the prognosis for patients with cancer remains poor (1). Esophageal cancer patients without detectable metastasis in the clinic at the time of diagnosis may still succumb to cancer recurrence following surgery (2). This suggests that certain metastasis of cancer may not be detected using conventional biochemistry testing, imaging or histopathological methods (2). Therefore, a novel biological marker that may enhance the ability to accurately predict patient treatment outcomes is required. In previous years, a number of studies have investigated potential prognostic factors in patients with cancer. Previous studies have demonstrated that certain preoperative alterations in hematological parameters may be associated with patient outcomes for several forms of solid tumors (3). In addition, it has been suggested that circulating platelet (PLT)-tumor cell aggregates may promote cancer metastasis (4).Previous studies have investigated the association between thrombocytosis and tumor growth and development in various forms of malignancy (5-7); however, this trend requires further investigation. Yu et al (8) demonstrated, using a meta-analysis, that thrombocytosis (PLT count >400x10 9 /l) may be associated with a poorer prognosis for patients with a gynecological malignancy. Therefore, the present meta-analysis was performed in order to assess the associati...

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Elevation of Platelet Count in Patients with Colorectal Cancer Predicts Tendency to Metastases and Poor Prognosis

Abstract: Elevated platelet might play some role in the progress of CRC and preoperative platelet count might be a prognostic indicator in the CRC patients.

Cited by 36 publications

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Low local blood perfusion, high white blood cell and high platelet count are associated with primary tumor growth and lung metastasis in a 4T1 mouse breast cancer metastasis model

Low local blood perfusion, high white blood cell and high platelet count are associated with primary tumor growth and lung metastasis in a 4T1 mouse breast cancer metastasis model

Prognostic Evaluation of Categorical Platelet-based Indices Using Clustering Methods Based on the Monte Carlo Comparison for Hepatocellular Carcinoma

The clinicopathological and prognostic role of thrombocytosis in patients with cancer: A meta-analysis

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