2013
DOI: 10.1007/s10517-013-2140-2
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Elevation of Seizure Threshold after Intranasal Administration of Anti-Glutamate Antibodies to C57Bl/6 Mice

Abstract: The dose-dependent effect of intranasal administration of antibodies to glutamate on acute generalized epileptic activity was studied in C57Bl/6 mice. It was shown that pretreatment with antibodies in doses of 100, 300, and 500 μg/kg 1 h before titration with convulsant pentylenetetrazole had anticonvulsant effects. This treatment was followed by an increase in the thresholds of clonic and tonic seizures with fatal outcome and lengthening of seizure latency. The most pronounced effect was observed in doses of … Show more

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