Elevation of Serum Apolipoprotein B after Successful Eradication of Hepatitis C Virus in Patients with Chronic Hepatitis C Treated by IFNBased Therapy

Abstract

Background: Hepatitis C Virus (HCV) infection is closely tied to the lipid metabolism of liver cells. We recently reported that serum levels of LDL-and VLDL-cholesterol (Cho) increased in patients with Chronic Hepatitis C (CHC) showing Sustained Virologic Response (SVR) after treatment with interferon (IFN)-based therapy. LDL-and VLDLCho contained apolipoprotein (apo)-B synthesized in the liver as a major protein component. The goal of the present study was to clarify how serum lipid markers change in CHC patients showing SVR after treatment with IFN-based therapy.