Elevation of Serum CA 125 and D-Dimer Levels associated with Rupture of Ovarian Endometrioma

Uharcek, P; Mlyncek, M; Ravinger, J.

doi:10.1177/172460080702200307

Cited by 8 publications

(4 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Extremely elevated CA 125 levels have been reported in the presence of both ruptured [ 5 , 7 , 9 , 10 , 12 , 30 ] and unruptured endometriomas [ 13 – 18 ] (Tables 1 and 2 ). The highest CA 125 level reported in proven endometriosis is 9537 U/ml following acute rupture of an endometrioma [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…The previous highest CA 125 level in the context of an unruptured endometrioma was 7900 U/ml [ 16 ]. This carries significant clinical importance as an elevated CA 125, especially in the presence of a pelvic mass, can mimic and raise suspicion of a malignant process leading to unnecessarily invasive procedures [ 15 , 30 ]. Education of the patient regarding the significance of an elevated tumour marker in the absence of a malignant tumour is of prime importance, with sensitivity to the potential emotional distress such words can impose.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Elevated CA 125 in a CASE of Leaking Endometrioma

Rao

Kapurubandara

Anpalagan

2018

Case Reports in Obstetrics and Gynecology

View full text Add to dashboard Cite

Extremely elevated CA 125, usually suggestive of ovarian malignancy, can be found in physiological or benign conditions such as endometriosis. We present a case of an extremely elevated serum CA 125 level in a patient with stage four endometriosis and bilateral unruptured ovarian endometriomas, with evidence of leakage unilaterally. To avoid costly and unnecessarily invasive tests and procedures it is important to consider the differential diagnosis of endometriosis and/or leaking endometrioma in patients with a profoundly elevated CA 125 level.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Elevated CA 125 in a CASE of Leaking Endometrioma

Rao

Kapurubandara

Anpalagan

2018

Case Reports in Obstetrics and Gynecology

View full text Add to dashboard Cite

show abstract

“…D‐dimer is a major degradation product of polymerized fibrin after blood coagulation and plasmin processing. Elevated plasma D‐dimer levels usually indicate active fibrinolysis and are observed in several disorders, including arterial and venous thromboembolic disease, disseminated intravascular coagulation, malignancy, and renal and liver disease . Serum D‐dimer has been reported as a useful diagnosis and prognosis parameter for several malignancies including ovarian cancer .…”

Section: Discussionmentioning

confidence: 99%

“…Serum D‐dimer has been reported as a useful diagnosis and prognosis parameter for several malignancies including ovarian cancer . In addition, some studies have shown an association between elevated D‐dimer and rupture of ovarian endometriotic cysts . For example, Tanaka et al .…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of serum D‐dimer,CA125, and neutrophil‐to‐lymphocyte ratio in differentiating ovarian cancer and endometriosis

Chen

Wang

Shu

et al. 2019

Intl J Gynecology & Obste

View full text Add to dashboard Cite

Objective: To assess the utility of hematologic, inflammatory, and immunologic biomarkers for differentiating between ovarian cancer and endometriosis.Methods: Data were retrospectively reviewed from women diagnosed with ovarian cancer and endometriosis after ovarian cyst surgery in Zhejiang, China, 2014 Serologic and hematologic biomarkers, including white blood cell count, lymphocyte count, neutrophil count, red blood cell count, hemoglobin, platelets, and D-dimer, albumin, globulin, cancer antigen 125 (CA125) and CA199 serum levels recorded preoperatively were assessed by ROC curve and logistic regression analysis. Results:Overall, 49 women were diagnosed with ovarian cancer and 192 with endometriosis. For predicting ovarian cancer, the area under the curve (AUC) was 0.96 (95% confidence interval [CI], 0.94-0.99); sensitivity, 93.2%; specificity, 87.5%) for log(Ddimer), 0.95 (95% CI, 0.91-0.98; sensitivity, 81.3%; specificity, 96.3%) for log(CA125), and 0.92 (95% CI, 0.86-0.98; sensitivity, 92.6%; specificity, 79.2%) for neutrophil-tolymphocyte ratio (NLR). The AUC for the combination of D-dimer, NLR, and CA125 was 0.96 (95% CI, 0.94-0.99; sensitivity, 91.6%; specificity, 89.6%).Conclusion: Serum D-dimer, NLR, and CA125 were found to be potential diagnostic factors for ovarian cancer. Combined measurement of D-dimer, NLR, and CA125 might offer a convenient screening method.

show abstract

Relation of high CA125 and CA19-9 levels with recent rupture of endometrioma

et al. 2011

View full text Add to dashboard Cite

Most of endometriomas with CA125 level over 1,000 IU/mL have related with rupture. This is important in differential diagnosis from malign ovarian disease. However, the mechanism of elevation of CA125 in patients with endometrioma is not clear. We reviewed elevation of CA125 level over 1,000 IU/mL in endometriomas and attempted to explore possible mechanisms of this elevation together with presentation of our current case. A review of the literature suggests that extremely elevated CA125 level combined with high CA19-9 level may indicate a recent rupture of endometrioma.

show abstract

Elevation of Serum CA 125 and D-Dimer Levels associated with Rupture of Ovarian Endometrioma

Cited by 8 publications

References 15 publications

Elevated CA 125 in a CASE of Leaking Endometrioma

Elevated CA 125 in a CASE of Leaking Endometrioma

Diagnostic value of serum D‐dimer,CA125, and neutrophil‐to‐lymphocyte ratio in differentiating ovarian cancer and endometriosis

Relation of high CA125 and CA19-9 levels with recent rupture of endometrioma

Contact Info

Product

Resources

About