Elevation of serum lactic dehydrogenase levels as an early marker of occult malignant lymphoma

Abstract

Elevated serum lactic dehydrogenase (LDH) levels, 595 to 615 μm/ml (normal < 225 μm/ml) with predominance of LDH isoenzymes 2 and 3 was the early and only sign of occult malignant lymphoma in three patients. In the first patient, overt lymphoma appeared clinically only 2 months after the finding of elevated serum LDH levels, whereas in the other two asymptomatic patients, pathologic LDH levels were the only clues to the need for further diagnostic investigation. It is concluded that LDH may have a diagnostic value in the preclinical stage of malignant lymphoma. Thus, a patient with no apparent cause for elevated serum LDH levels warrants a thorough work‐up including abdominal CT scan and even explorative laparotomy.

Clinical relevance of serial determinations of lactate dehydrogenase activity used to predict recurrence in dogs with lymphoma

“…13 Additionally, elevated serum LDH activities in patients without clinical signs may precede the onset of the clinical stage for occult lymphoma. [13][14][15] Measurement of LDH activity in small animals with lymphoma has gained attention [16][17][18][19] ; however, little information is available on the clinical importance of LDH activity in the canine species regarding prognosis or follow-up monitoring. [13][14][15] Measurement of LDH activity in small animals with lymphoma has gained attention [16][17][18][19] ; however, little information is available on the clinical importance of LDH activity in the canine species regarding prognosis or follow-up monitoring.…”

Lactic acidosis, non-Hodgkins lymphoma and the acquired immunodeficiency syndrome.

“…After 14 weeks' treatment with ciprofloxacin and abscess cavity packing, swabs taken from the cavity yielded no bacterial growth. Wound care with granuflex was commenced and treatment with ciprofloxacin continued for a further 5 weeks. The abscesses were completely healed 23 weeks after the patient's initial presentation.…”

Übersichtsreferate

“…Geburtstag gewidmet In der vorliegenden Arbeit wird die Bedeutung verschiedener Laborparameter für die Diagnostik und Verlaufskontrolle von malignen Non-Hodgkin-Lymphomen (NHL) untersucht. In den bisher vorliegenden Publikationen zu diesem Thema (1 -13) wurde in der Regel nur ein Parameter (2)(3)(4)(5)(6)10,11,13) oder eine Gruppe gleichartiger Parameter (1,(7)(8)(9)12) berücksichtigt. Zudem wurde meist die in Deutschland nicht gebräuchliche zugrunde gelegt, während wir die histologische Zuordnung nach der Kiel-Klassifikation (15) …”