Elevation of serum prostagladin E levels following electrical stimulation of the midbrain

Behavioral changes were induced in rats by administration of high doses of amphetamine (5 mg/kg): among these was the development of rapid sniffing. The effect of electrical stimulation of the midbrain periaqueductal gray was then examined. This stimulation is known to release an enkephalin-like substance into the ventricular spinal fluid and to induce analgesia. Stimulation blocked amphetamine-induced sniffing. This effect was blocked in turn by pretreatment with naloxone, a specific opiate antagonist. We discuss this finding in the context of opiate-catecholamine antagonism in the CNS.

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Effect of midbrain stimulation on amphetamine-induced stereotypy in rats

Tasman

Simon

1983

Psychopharmacology

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Elevation of serum prostagladin E levels following electrical stimulation of the midbrain

Cited by 1 publication

References 30 publications

Effect of midbrain stimulation on amphetamine-induced stereotypy in rats

Effect of midbrain stimulation on amphetamine-induced stereotypy in rats

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