Elevation of Tissue PO2 with Improvement of Tissue Perfusion by Topically Applied CO2

Effects if co2-baths in the combined concept of the early functional therapy in the cases of reflex sympathetic dystrophy

“…By analogy to the results of other investigations (Hartmann et al, 1991;Koles·r, 1984;Komoto et al, 1988) several influence factors must be discussed: analgesic effects via the cutaneous stimulus compensation by the CO 2 which is tolerable even in the highly active phase, since according to Sato and Schmidt (1973) corresponding deficits maintain reflex dystrophic nociception. Pain intensity is modified by regulatory effects on the painful hypertensive musculature and systemic effects of relaxation (Zysno, 1974).…”

“…Physiotherapy addresses the symptom-complex In contrast to other local applications, the CO 2 bath is tolerated even in highly acute reflex sympathetic dystrophy. By analogy to the numerous objective effects observed (Ernst et al, 1984;Hartmann et al, 1991;Ito et al, 1989;Koles·r et al, 1984;Komoto et al, 1988;Kwant et al, 1988) modulation of oedema and pain as well as vasomotor stimulation is inferred. In numerous observational and prospective comparison studies, the efficacy of this combination therapy could be documented (Mucha, 1987(Mucha, , 1988Mucha and Zysno, 1984).…”

Oxygen Breathing Affects 3′-Deoxy-3′-18F-Fluorothymidine Uptake in Mouse Models of Arthritis and Cancer

“…Oxygen plays a critical role in wound healing by blocking the proliferation of inflammatory cells (27)(28)(29) and increasing adenosine triphosphate degradation (30). Moreover, breathing oxygen may decrease blood flow in tumors as a consequence of vasoconstriction (31,32).…”

Immersion in CO2-rich water containing NaCl diminishes blood pressure fluctuation in anesthetized rats

“…Studies of the CO 2 -hot springs used in balneotherapy have focused on analyzing the action mechanism of CO 2 because of its remarkable effects on the cardiovascular functions of humans and experimental animals (Hashimoto and Yamamoto 2004;Komoto et al 1988;McClellan 1963;Nishimura et al 2002). A recent study using artificial CO 2 -hot spring water and laboratory animals has revealed that CO 2 , the principal ingredient of CO 2 -hot springs, works percutaneously and reduces heart rate compared with tap water baths (Hashimoto and Yamamoto 2004).…”