Eleven pairs of Japanese male twins suggest the role of epigenetic differences in androgenetic alopecia

Koyama, Tadanobu; Kobayashi, Kenzo; Wakisaka, Nagaoki; Hirayama, Nobuo; Konishi, S.; Hama, Takanori; Takeda, Katsuyuki; Nakamizo, Yoshio; Kawakami, M

doi:10.1684/ejd.2012.1898

Cited by 6 publications

(3 citation statements)

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“…The environmental factors examined have been adequately reported, and the basis and the mechanistic explanations provided were congruent with previous findings [67], [68], [69], [72], [89], [90], [91], [92], [93], [94]. The cross-sectional nature of the measurements of blood metals and personal behaviors (for example, sleep patterns [67], [68], [70], [94] and oily scalp [62], [95], [96], [97], [98], [99], [100]) limit our ability to identify causal relationships; the time of onset of moderate to severe hair loss will need more investigation in future work.…”

Section: Discussionsupporting

confidence: 85%

“…One limitation of this study is that AGA may be affected by many genes that have not yet been identified; twin studies have shown that the AGA condition is heritable, and a family history of AGA has been included in our analysis for this reason. However, there are still many findings [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88] that suggest that heritable and epigenetic [69], [89] differences also play a role in alopecia; this may replace the classical discussion of the roles of genetic and environmental factors in alopecia.…”

Section: Discussionmentioning

confidence: 99%

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Androgenic Alopecia Is Associated with Less Dietary Soy, Higher Blood Vanadium and rs1160312 1 Polymorphism in Taiwanese Communities

et al. 2013

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BackgroundAlthough the genetic basis of androgenic alopecia has been clearly established, little is known about its non-genetic causes, such as environmental and lifestyle factors.ObjectiveThis study investigated blood and urine heavy metals concentrations, environmental exposure factors, personal behaviors, dietary intakes and the genotypes of related susceptibility genes in patients with androgenic alopecia (AGA).DesignAge, AGA level, residence area, work hours, sleep patterns, cigarette usage, alcohol consumption, betel nut usage, hair treatments, eating habits, body heavy metals concentrations and rs1998076, rs913063, rs1160312 and rs201571 SNP genotype data were collected from 354 men. Logistic regression analysis was performed to examine whether any of the factors displayed odds ratios (ORs) indicating association with moderate to severe AGA (≧IV). Subsequently, Hosmer-Lemeshow, Nagelkerke R2 and accuracy tests were conducted to help establish an optimal model.ResultsModerate to severe AGA was associated with the AA genotype of rs1160312 (22.50, 95% CI 3.99–126.83), blood vanadium concentration (0.02, 95% CI 0.01–0.04), and regular consumption of soy bean drinks (0.23, 95% CI 0.06–0.85), after adjustment for age. The results were corroborated by the Hosmer-Lemeshow test (P = 0.73), Nagelkerke R2 (0.59), accuracy test (0.816) and area under the curve (AUC; 0.90, 0.847–0.951) analysis.ConclusionsBlood vanadium and frequent soy bean drink consumption may provide protect effects against AGA. Accordingly, blood vanadium concentrations, the AA genotype of rs1160312 and frequent consumption of soy bean drinks are associated with AGA.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Androgenic Alopecia Is Associated with Less Dietary Soy, Higher Blood Vanadium and rs1160312 1 Polymorphism in Taiwanese Communities

et al. 2013

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“…However, the true heritability may even be higher, as any random misclassification of AGA severity, for example in studies involving self‐assessment, would lead to an underestimation of the heritability. The issue of whether environmental factors – in some instances mediated through epigenetic mechanisms – are involved in AGA remains unclear .…”

Section: Why Is Aga Considered To Be Heritable?mentioning

confidence: 99%

Hunting the genes in male‐pattern alopecia: how important are they, how close are we and what will they tell us?

Nöthen

Hochfeld

Paus

et al. 2016

Experimental Dermatology

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Androgenetic alopecia (AGA) is a highly heritable condition, and the most common form of hair loss in men. The phenotype is characterized by an androgen-dependent, progressive loss of hair from the scalp, which may commence during puberty. Up to 80% of European men experience some degree of androgen-dependent hair loss during their lifetime. Current treatment options for AGA have limited efficacy, and improved understanding of the underlying biological causes is required to facilitate novel therapeutic approaches. To date, molecular genetic studies have implicated 12 genomic regions in AGA and identified a number of candidate genes. The latter include those encoding the androgen receptor (AR), the histone deacetylases (HDAC) 4 and 9, and the WNT molecule WNT10A. However, the majority of contributing genetic risk factors still await identification. This review describes the current status of AGA genetic research. We discuss the strength of the genetic approach and anticipated developments in the field, and how these will facilitate the systematic unravelling of AGA pathobiology, a process which may lead to the identification of new therapeutic targets.

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Micronutrients and Androgenetic Alopecia: A Systematic Review

Wang,

Lin,

Liu

et al. 2024

Molecular Nutrition Food Res

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ScopeHair loss is a common problem that can negatively impact individuals' psychological well‐being. Androgenetic alopecia (AGA) is one of the most prevalent types of nonscarring hair loss. This review summarizes the existing evidence on the relationship between AGA and various micronutrients, including vitamin B, vitamin D, vitamin A, vitamin C, iron, selenium, zinc, manganese, and copper.MethodsA literature search was conducted to identify relevant articles published between 1993 and 2023. The search identified 49 relevant articles.ResultsThe findings suggest that deficiencies or imbalances in these micronutrients may contribute to the pathogenesis of AGA and represent modifiable risk factors for hair loss prevention and treatment. Vitamin B, vitamin D, iron, and zinc appear to play critical roles in hair growth and maintenance. Deficiencies in these micronutrients have been associated with increased risk of AGA, while supplementation with these nutrients has shown potential benefits in improving hair growth and preventing hair loss. However, the current evidence is not entirely consistent, with some studies reporting no significant associations.ConclusionDeficiencies or imbalances in specific vitamins and minerals, especially vitamin B, vitamin D, Fe, Se, and Zn are involved in the pathogenesis of AGA and may represent modifiable risk factors for the treatment and prevention of this condition.

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Eleven pairs of Japanese male twins suggest the role of epigenetic differences in androgenetic alopecia

Cited by 6 publications

References 0 publications

Androgenic Alopecia Is Associated with Less Dietary Soy, Higher Blood Vanadium and rs1160312 1 Polymorphism in Taiwanese Communities

Androgenic Alopecia Is Associated with Less Dietary Soy, Higher Blood Vanadium and rs1160312 1 Polymorphism in Taiwanese Communities

Hunting the genes in male‐pattern alopecia: how important are they, how close are we and what will they tell us?

Micronutrients and Androgenetic Alopecia: A Systematic Review

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