Eleven-Vertex Carboranes

Carborane-Containing Polymers: Synthesis, Properties, and Applications

“…However, it is possible to deprotonate the slightly acidic CH groups (p K a ∼ 22) using strong bases such as n BuLi, and the resulting carbanion can be reacted with a large number of suitable electrophiles . Alternatively, a single BH unit can be removed from closo -carboranes to afford the corresponding hydrophilic nido -[C 2 B 9 H 12 ] − anion via an efficient, regioselective and high-yielding deboronation reaction involving nucleophiles including hydroxide, fluoride, tertiary amines, and other nitrogenous bases. , Over the years, carborane molecules have been intensively studied as, e.g., fluorophores, , drug carriers, enzyme inhibitors, , antibiotics, and potential agents for boron neutron capture therapy (BNCT), , an experimental binary cancer treatment that exploits the thermal neutron capture reaction of 10 B to kill tumor cells by means of an intracellular fission process.…”

Employment of chiral columns with superficially porous particles in chiral separations of cobalt bis (dicarbollide) and nido‐7,8‐C2B9H12(1‐) derivatives

“…In particular, the latter ion has been intensively studied because of electronic and structural similarities to organometallic ferrocenes. Investigations of COSAN are nearly as extensive as studies on its parent ligand, that is, nido ‐7,8‐C 2 B 9 H 12 (1‐) 3 …”

“…Investigations of COSAN are nearly as extensive as studies on its parent ligand, that is, nido-7,8-C 2 B 9 H 12 (1-). 3 The high thermal and chemical stability of COSAN and its derivatives led to their employment in materials chemistry, 4-6 electrochemistry, 7,8 and analytical chemistry. 9,10 The growing knowledge of COSAN chemistry led to the investigation of its derivatives in medicinal chemistry.…”

“…optimization process was carried out on the CDShell-RSP column for enantioseparated analytes from the chiral screening and on the VancoShell and Larihc-Shell P columns for analyte A 11. The optimization of the mobile phase composition on CDShell-RSP was carried out by varying the pH(3,4, or without adjustment), the ionic strength(5, 10, 20, 50, or 100 mmol/l) of the NH 4 FA buffer, and the type of the additive (NH 4 FA [20 mmol/l], NH 4 TFA [20 mmol/l], NH 4 TFA [20 mmol/l] + TFA [0.1%, v/v], NaClO 4 [20 mmol/l], or TFA [0.1%, v/v] + TEA [0.1%, v/v]). Optimization of the mobile phase MeOH + NH 4 TFA (0.1%, w/v) on VancoShell was carried out by adding the TFA and changing the NH 4 TFA (w/v)-TFA (v/v) ratio.…”

Synthesis and Reactivity of Cyclic Oxonium Derivatives of nido-Carborane: A Review

“…Currently the main approach to the synthesis of nido-carborane derivatives is based on the deboronation of the corresponding ortho-carborane derivatives. This approach is widely used for the synthesis of C-substituted derivatives of nido-carborane, as well as derivatives containing substituents at the lower belt of the nido-carborane cage [40]. There are several general methods for the synthesis of B-substituted derivatives with substituents in the upper belt of the nido-carborane cage; however, most of them are used to obtain asymmetrically substituted derivatives [9-X-7,8-C 2 B 9 H 11 ] − [41][42][43][44][45][46][47][48][49].…”