Eleven-year follow-up results in the delay of breast irradiation after conservative breast surgery in node-negative breast cancer patients

Vujovic, Olga; Yu, Edward; Cherian, Anil; Dar, A. Rashid; Stitt, Larry; Perera, Francisco

doi:10.1016/j.ijrobp.2005.08.004

Cited by 40 publications

(25 citation statements)

References 12 publications

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“…Vujovic et al reported that delay in the start of breast irradiation of up to 16 weeks from definitive surgery does not increase the risk of recurrence in node-negative (N0) breast cancer patients. The ''unfavorable'' aspect of the delay is apparently associated with high recurrence rates in patients with positive surgical margins [20,21]. In our present study, less than 10% of patients had a waiting period of greater than 8 weeks, which is unlikely to be found statistically as a risk factor for recurrence within the breast.…”

Section: Radiotherapycontrasting

confidence: 54%

The treatment outcome of patients undergoing breast-conserving therapy: the clinical role of postoperative radiotherapy

Oouchi

Sakata

Masuoka³

et al. 2008

Breast Cancer

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Section: Radiotherapycontrasting

confidence: 54%

The treatment outcome of patients undergoing breast-conserving therapy: the clinical role of postoperative radiotherapy

Oouchi

Sakata

Masuoka³

et al. 2008

Breast Cancer

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“…Vujovic et al (5) have also previously published similar results that showed no difference in local recurrence or survival for surgery-radiotherapy intervals of #16 weeks. However, no information is available on the effect of the interval from clinical presentation to definitive surgery on local recurrence or survival in patients presenting with early-stage breast cancer.…”

Section: Discussionmentioning

confidence: 71%

“…In early-stage invasive breast cancer, several studies have shown that no detrimental effect on local recurrence or survival occurs for intervals from definitive breast surgery to breast irradiation of #20 weeks (1)(2)(3)(4)(5). However, similar information is not available for the effect of the interval from clinical presentation to definitive breast surgery.…”

Section: Introductionmentioning

confidence: 99%

Effect of Interval to Definitive Breast Surgery on Clinical Presentation and Survival in Early-Stage Invasive Breast Cancer

Vujovic

Cherian³

et al. 2009

International Journal of Radiation Oncology*Biology*Physics

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“…In a single-institution study, also from Quebec, the time to breast rt was associated with an increase in local recurrence in univariate analysis, but the effect became equivocal in multivariate analysis 16. A study conducted in Ontario could not find an effect of time to rt on local control in a stepwise multivariate Cox regression model 17,18. Theoretic models of tumour control probability predict that delays in initiating treatment will have an adverse effect on local control, especially for rapidly growing tumours 19.…”

Section: Discussionmentioning

confidence: 99%

Radiation Treatment Waiting Times for Breast Cancer Patients in Manitoba, 2001 and 2005

et al. 2009

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IntroductionOur study examined the wait time from ready-to-treat to radiation therapy for cohorts of breast cancer patients requiring adjuvant radiation therapy in 2001 and in 2005 after the implementation of strategies to reduce wait times for radiation treatment. We also examined the overall time from diagnosis to radiation treatment and whether distance from the cancer treatment centre or month of referral had an effect on wait times.MethodsThis population-based retrospective study looked at representative samples of women newly diagnosed with breast cancer in 2001 and 2005. Patients who required radiation treatment to the breast or chest wall were followed from first contact to the start of radiation treatment.ResultsTime from ready-to-treat to first radiation treatment was significantly reduced for patients in 2005 as compared with 2001, regardless of whether chemotherapy was administered before radiation treatment. Time from diagnosis to radiation treatment was not different by year for those who received radiation only. Time from diagnosis to chemotherapy was significantly longer in 2005. No effect of month of diagnosis on wait times was observed.InterpretationA significant improvement in the median wait time from ready-to-treat to first radiation treatment was noted from 2001 to 2005. This improvement may be attributable to measures taken to reduce such waits. However, we observed an increase in the median time from diagnosis to referral and from referral to consultation with medical or radiation oncology (or both), so that the overall time from diagnosis to radiation treatment was not different. Although specific intervals related to radiation treatment delivery were improved, the entire trajectory of breast cancer care experienced by patients needs to be considered.

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Eleven-year follow-up results in the delay of breast irradiation after conservative breast surgery in node-negative breast cancer patients

Cited by 40 publications

References 12 publications

The treatment outcome of patients undergoing breast-conserving therapy: the clinical role of postoperative radiotherapy

The treatment outcome of patients undergoing breast-conserving therapy: the clinical role of postoperative radiotherapy

Effect of Interval to Definitive Breast Surgery on Clinical Presentation and Survival in Early-Stage Invasive Breast Cancer

Radiation Treatment Waiting Times for Breast Cancer Patients in Manitoba, 2001 and 2005

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